This SRC provides an interactive forum that covers the latest developments in the small GTPase field and presents the newest technological advancements that are being used to unravel the complex roles of small GTPases in human health and disease. Small GTPases (e.g. Ras, Rac, Rho, Cdc42, Rab, Rap, Rheb and Ral) are essential for key cellular processes such as cell differentiation, proliferation, and migration, as well as the regulation of subcellular events such as vesicle trafficking. These critical functions of small GTPases make them important participants in a wide variety of physiological and pathophysiological processes. The founding member of the small GTPase superfamily, Ras, is the most commonly mutated oncogene in human cancers, and many other small GTPases (including RhoA, Rac1, Rab5, Rheb, and RalA) also play fundamental roles in cancer development and progression. Due to these important oncogenic functions of small GTPases, there is a strong cancer theme underlying this meeting. However, small GTPases also participate in other biomedically important events, including the promotion of vascular diseases, immunological abnormalities, mental disorders, and metabolic conditions. For these reasons, progress from a number of fields in addition to cancer biology will be highlighted, including neurobiology, developmental biology, computational biology, and membrane biophysics to ensure that we are leveraging and learning from discoveries made in important related fields. The main objective of the meeting is to stimulate cross-pollination of ideas among researchers investigating basic biochemical mechanisms, cell and tissue biology, and translational models to define the diverse functions of small GTPases.