Konferenzen zum Thema Biologie in Kanada

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1.
 
Keystone Symposia - B Cells and T Follicular Helper Cells – Controlling Long-Lived Immunity
ID
825319
Termin
23. Apr 2017 - 27. Apr 2017
Ort
Whistler, British Columbia, Kanada
Zusammenfassung
B cells are fundamental for the development of long-lived immunological memory following exposure to infectious pathogens and, consequently, for the success of the vast majority of currently-available vaccines. The differentiation of B cells into the effector cells of serological memory – memory B cells and plasma cells – occurs in germinal centers. However this process critically requires a specialized subset of CD4+ T cells termed T follicular helper (Tfh) cells. The integration of signals required to generate germinal center B cells, memory and plasma cells, and Tfh cells are strictly controlled. This is to ensure the efficient selection of antigen-specific high-affinity effector cells, and to prevent the development of immune dyscrasias associated with GCs, such as autoimmunity, immune deficiency and malignancy – conditions that can develop when the complexities of lymphocyte differentiation in germinal centers are dysregulated. Despite the substantial advances that have been made in understanding the cellular, biochemical and molecular requirements for the generation of effective T-dependent B-cell responses, major questions regarding these processes remain. Answers to such questions are needed so as to be able to harness the intrinsic function of memory B cells, plasma cells and Tfh cells in order to enhance immunity in immunocompromised individuals, improve vaccine design and develop novel vaccines for infectious pathogens, as well as to attenuate humoral immune responses in the setting of autoantibody-mediated autoimmune diseases. This meeting will bring together basic and clinical immunologists to address unanswered questions and to discuss the latest cutting-edge breakthroughs in the biology of B cells and Tfh cells to facilitate development of new translational strategies of regulating their behavior in human immunopathologies.
Kontakt
Tel.: [1 800-253-0685];     Email: info@keystonesymposia.org
Themen
T Follicular Helper Cells, B Cells, Immunity, Vaccines, B Cell Memory, Plasma Cells, Transcriptional Regulation, Lymphocyte Signaling, Immunodeficiency, Autoimmunity, GCs, Germinal Center Response, Germinal Center Dynamics
2.
 
IPS2017 — 10th General Meeting of the International Proteolysis Society
ID
871243
Termin
27. Okt 2017 - 01. Nov 2017
Ort
Banff, Kanada
Zusammenfassung
From a cell’s birth during mitosis or meiosis to its death by one of the several modalities that exist, peptidases shape all activities of a cell’s life and, by extension, of all organisms. It is thus not surprising that most pathologies have proteolytic activity either as a cause or as a contributing factor. Despite the fact that peptidases have been the focus of intense scrutiny for more than 135 years (who doesn’t recall the 1880 work by M. Ad. Wortz on papain?), we still have much to learn, helped by genetics, ‘-omics’, chips, libraries, chemistry, cell biology, imaging tools and good old fashion biochemistry. With all that in mind and with new territories to explore, we propose Frontier in proteolysis as a meeting motto to highlight where we have been and where proteolysis research will lead us.
Kontakt
Jean-Bernard Denault;     Email: info@ips2017.org

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Stand vom 21. Januar 2017