Konferenzen zum Thema Biologie in Kanada

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1.
 
Keystone Symposia - Immune Regulation in Autoimmunity and Cancer
ID
825336
Termin
26. Mär 2017 - 30. Mär 2017
Ort
Whistler, British Columbia, Kanada
Zusammenfassung
While the importance of adoptive and innate immunity has been clear in the pathogenesis of human autoimmune disease resulting in a multitude of immune-based therapeutic approaches, the realization is now apparent that understanding immune evasion by cancer is central in developing curative treatments. This meeting will explore and contrast the underlying immune mechanisms resulting in autoimmunity and tumor evasion. The meeting is innovative in bringing together basic immunologists investigating mechanisms of tolerance with scientists exploring immune mechanisms of autoimmunity and cancer in both patients and experimental models. Thus, this Keystone Symposia meeting will cover the pathways in immunity and tolerance that lead to loss of immunological control, dysregulated immune responses and chronic inflammatory disease or tumor evasion. Presentations will include consideration of preclinical and clinical aspects of a diverse number of autoimmune and inflammatory diseases and cancer. Conference participants engaged in preclinical, translational and clinical research will hopefully engage in continuing conversations and collaborations which, over the long-term, will provide greater insights into the human immune response and allow us to reassess and further explore pathways that are driving autoimmune disease yet in opposition, lead to tumor evasion. Understanding checkpoints in autoimmunity and immune cell tolerance is important for delivering therapies to patients with autoimmune disease and cancer, and this meeting will provide a platform for the cross-pollination of clinical experience and experimental research. Attendees will have learned about the impact of targeted immune-based therapeutics on clinical outcome and, consequently, be able to widen their research scope accordingly.
Kontakt
Tel.: [1 800-253-0685];     Email: info@keystonesymposia.org
Themen
Immune Regulation, Autoimmunity, Cancer, Tissue Micro-Immune Environments, Autoimmune Tissue Inflammation, T Cell Tolerance, Effector T Cell Dysfunction, Innate Regulation, B Cell Regulation, Th17 Cell
Verwandte Fachgebiete
2.
 
Keystone Symposia - B Cells and T Follicular Helper Cells – Controlling Long-Lived Immunity
ID
825286
Termin
23. Apr 2017 - 27. Apr 2017
Ort
Whistler, British Columbia, Kanada
Zusammenfassung
B cells are fundamental for the development of long-lived immunological memory following exposure to infectious pathogens and, consequently, for the success of the vast majority of currently-available vaccines. The differentiation of B cells into the effector cells of serological memory – memory B cells and plasma cells – occurs in germinal centers. However this process critically requires a specialized subset of CD4+ T cells termed T follicular helper (Tfh) cells. The integration of signals required to generate germinal center B cells, memory and plasma cells, and Tfh cells are strictly controlled. This is to ensure the efficient selection of antigen-specific high-affinity effector cells, and to prevent the development of immune dyscrasias associated with GCs, such as autoimmunity, immune deficiency and malignancy – conditions that can develop when the complexities of lymphocyte differentiation in germinal centers are dysregulated. Despite the substantial advances that have been made in understanding the cellular, biochemical and molecular requirements for the generation of effective T-dependent B-cell responses, major questions regarding these processes remain. Answers to such questions are needed so as to be able to harness the intrinsic function of memory B cells, plasma cells and Tfh cells in order to enhance immunity in immunocompromised individuals, improve vaccine design and develop novel vaccines for infectious pathogens, as well as to attenuate humoral immune responses in the setting of autoantibody-mediated autoimmune diseases. This meeting will bring together basic and clinical immunologists to address unanswered questions and to discuss the latest cutting-edge breakthroughs in the biology of B cells and Tfh cells to facilitate development of new translational strategies of regulating their behavior in human immunopathologies.
Kontakt
Tel.: [1 800-253-0685];     Email: info@keystonesymposia.org
Themen
T Follicular Helper Cells, B Cells, Immunity, Vaccines, B Cell Memory, Plasma Cells, Transcriptional Regulation, Lymphocyte Signaling, Immunodeficiency, Autoimmunity, GCs, Germinal Center Response, Germinal Center Dynamics
3.
 
IPS2017 — 10th General Meeting of the International Proteolysis Society
ID
871210
Termin
27. Okt 2017 - 01. Nov 2017
Ort
Banff, Kanada
Zusammenfassung
From a cell’s birth during mitosis or meiosis to its death by one of the several modalities that exist, peptidases shape all activities of a cell’s life and, by extension, of all organisms. It is thus not surprising that most pathologies have proteolytic activity either as a cause or as a contributing factor. Despite the fact that peptidases have been the focus of intense scrutiny for more than 135 years (who doesn’t recall the 1880 work by M. Ad. Wortz on papain?), we still have much to learn, helped by genetics, ‘-omics’, chips, libraries, chemistry, cell biology, imaging tools and good old fashion biochemistry. With all that in mind and with new territories to explore, we propose Frontier in proteolysis as a meeting motto to highlight where we have been and where proteolysis research will lead us.
Kontakt
Jean-Bernard Denault;     Email: info@ips2017.org

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Stand vom 21. Januar 2017