miRNA signature in early-stage mycosis fungoides
Oral presentation
Sissel T Sørensen
(Department of Dermatology, Aarhus University Hospital, Aarhus)
Background
Altered miRNA expressions are assigned pathogenic properties in several cancers including mycosis fungoides (MF) and could play a role in the early onset of the disease.
Objective
To examine disease specific miRNA expression in early-stage MF patch and plaque lesions.
Methods
We used a qRT-PCR platform of 384 human miRNAs to study the miRNA expression in 154 diagnostic MF biopsies.
Results
One-hundred-and-ten miRNAs were significantly differentially expressed (>two-fold, P<0.05) between plaque lesions and healthy controls, and 90 miRNAs (>two-fold, P<0.05) differed between patch lesions and healthy controls. Moreover, 13 miRNAs differed in expression between patch and plaque lesions. Early-stage MF exhibited miRNA features overlapping with psoriasis. However, 39 miRNAs, including miR-142-3p, miR-150 and miR-146b, were MF specific.
Conclusion
Early-stage MF express a distinct miRNA profile indicating that miRNAs play a role in the early development of MF.