Monday, 22 January
12:00 - 13:00
Welcome coffee
13:00 - 14:00
Opening Session
Louis Armand
Chair/s: John DE VOS
13:00
Welcome words by the FSSCR President and the Local Organizing Committee.
13:15
OS-01-Keynote Speaker
Deconstructing human musculo-skeletal development in vitro
Olivier Pourquié, Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Women’s Hospital, Boston, United States | Harvard Stem Cell Institute, Harvard University, Cambridge, United States
14:00 - 15:05
Self-organization of tissues and organoids
Chair/s: Cécile MARTINAT, Nathalie DIDIER
14:00
S1-01-Invited Speaker
Modelling of epithelial polarity defects in iPSC-derived intestinal organoids
Marianna Parlato, Institut Imagine, Paris, France
14:25
S1-02-Oral Short Talk
Coordination between cell specification and a cadherin switch underlies the potential of self-organization in gastruloids
Alexandre Mayran, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
14:40
S1-03-Oral Short Talk
Deciphering microenvironment cues to maintain human notochordal cells phenotype and to drive their maturation toward adult disc cells
Julie Warin, Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France
14:55
S1-04-Poster Teaser
Recapitulating cranial myogenesis in stem cell-based ex vivo models
Giada Mura, Stem Cells & Development Unit, UMR CNRS 3738, Institut Pasteur, Paris, France
14:56
S1-05-Poster Teaser
Development of a retinal engineering tissue for the treatment of retinal degenerative disorders
Camille Geiger, INSERM U861, I-Stem, AFM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, Corbeil-Essonnes, France | Université Paris-Saclay, Université d’Evry, Corbeil-Essonnes, France | Centre d’Etude des Cellules Souches, Corbeil-Essonnes, France
14:57
S1-06-Poster Teaser
Notch-Yap crosstalk represents a conserved mechanism regulating symmetry breaking of embryonic glandular epithelial cells
Robin Journot, Institut Curie, Paris, France
14:58
S1-07-Poster Teaser
Cortical organoids and brain assembloids as developmental model for studying the CACH leukodystrophy.
Théo La Rosa, Univ Lyon, Université Lyon 1, INSERM, INRAE, U1208, USC1361, Stem Cell and Brain Research Institute, Bron, France
14:59
S1-08-Poster Teaser
An organoid-based functional study of digenic inheritance of PAX3 and SFRP5 underlying syndromic myelomeningocele
Camil Mirdass*, Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France
15:05 - 15:50
Coffee Break - Exhibition - Posters
15:50 - 17:25
Organoid and animal models
Chair/s: Anne CAMUS, Eva MOINARD
15:50
S2-01-Invited Speaker
Transition Zone Stem Cells from function in organ homeostasis to their role in a perturbed state
Géraldine GUASCH, Centre de Recherche en Cancérologie de Marseille, INSERM U1068, MARSEILLE, France
16:15
S2-02-Oral Short Talk
Mechanisms of leukemia brain metastasis in a new humanized model of vascularized brain organoids
Loïc Le Guennec, Leukemia and Niche Dynamics Lab, Institut Cochin, INSERM U1016, CNRS UMR8104, Universite Paris Cite, Paris, France
16:30
S2-03-Oral Short Talk
French Center for 3Rs: Promotion of Open Science
Athanassia Sotiropoulos, GIS FC3R, Maisons Alfort, France | Inserm U1016, Institut Cochin, Paris, France
16:45
S2-04-Invited Speaker
In organoids we trust (to model human developmet).
Ludovic Vallier, Berlin Institute of Health, Berlin, Germany
17:10
S2-05-Sponsor Presentation
Enhancing Genetic Stability in Human Pluripotent Stem Cells Maintained as Single Cells
Camille TEMPIER LEMEY, STEMCELL Technologies, Montpellier, France
17:15
S2-06-Poster Teaser
Expanding gastruloids potential through high throughput imaging-based screening
Yuliia Romaniuk, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
17:16
S2-07-Poster Teaser
Enhancing CRISPR-Cas9 Efficiency in iPS Cells Using the NanoBlades Pseudoviral Vectorization System
Ambre LELEU, SupBiotech/CEA DRF IBFJ SEPIA – SupBiotech Ecole d’Ingénieur, Villejuif, France
17:17
S2-08-Poster Teaser
IALI : a model of airway epithelium derived from iPSC to study SARS-CoV-2 infection and antiviral drugs effectiveness.
Lisa MORICHON, CEMIPAI: Centre d’Etude des Maladies Infectieuses et Pharmacologie Anti-Infectieuses, CNRS UAR3725, Montpellier, France | Institute of Regenerative Medecine and Biotherapy, Université de Montpellier, CHU de Montpellier, INSERMU1183, Montpellier, France
17:18
S2-09-Poster Teaser
Neural organoids from progeroid and neurodegenerative Cockayne syndrome display defects correlated with the clinical condition
Tara Fournier, Molecular Mechanisms of Pathological and Physiological Ageing, Dept. of Developmental and Stem Cell Biology, CNRS UMR3738, Institut Pasteur, Paris, France | Sorbonne Université, Collège Doctoral, F-75005, Paris, France
17:19
S2-10-Poster Teaser
Engineered 3D muscle constructs for modeling Duchenne Muscular Dystrophy and high-throughput screening of novel therapeutics
Ghislain BANOS, Univ Paris Est Créteil, INSERM, EFS, IMRB, F-94010, Créteil, France
17:20
S2-11-Poster Teaser
IPearls: Large-scale production of pluripotent stem cell-derived liver organoids through liquid-core encapsulation
Zoé Tiprez, UMR_S 1193, INSERM/Université Paris-Saclay, Villejuif, France | Fédération Hospitalo-Universitaire (FHU) Hépatinov, Villejuif, France
17:30 - 19:30
Wine & Cheese welcome reception
17:30 - 19:30
Posters session 1
Exhibition & Poster Hall

THE POSTERS ARE LISTED IN THE ORDER OF THE GRID NUMBERS FROM 1 TO 66

PS1-01-Poster Teaser
Recapitulating cranial myogenesis in stem cell-based ex vivo models
Giada Mura, Stem Cells & Development Unit, UMR CNRS 3738, Institut Pasteur, Paris, France
PS1-02-Poster Teaser
Development of a retinal engineering tissue for the treatment of retinal degenerative disorders
Camille Geiger, INSERM U861, I-Stem, AFM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, Corbeil-Essonnes, France | Université Paris-Saclay, Université d’Evry, Corbeil-Essonnes, France | Centre d’Etude des Cellules Souches, Corbeil-Essonnes, France
PS1-03-Poster Teaser
Cortical organoids and brain assembloids as developmental model for studying the CACH leukodystrophy.
Théo La Rosa, Univ Lyon, Université Lyon 1, INSERM, INRAE, U1208, USC1361, Stem Cell and Brain Research Institute, Bron, France
PS1-04-Poster Teaser
An organoid-based functional study of digenic inheritance of PAX3 and SFRP5 underlying syndromic myelomeningocele
Camil Mirdass*, Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France
PS1-05-Poster Teaser
Notch-Yap crosstalk represents a conserved mechanism regulating symmetry breaking of embryonic glandular epithelial cells
Robin Journot, Institut Curie, Paris, France
PS1-06-Poster Teaser
Expanding gastruloids potential through high throughput imaging-based screening
Yuliia Romaniuk, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
PS1-07-Poster Teaser
Engineered 3D muscle constructs for modeling Duchenne Muscular Dystrophy and high-throughput screening of novel therapeutics
Ghislain BANOS, Univ Paris Est Créteil, INSERM, EFS, IMRB, F-94010, Créteil, France
PS1-08-Poster Teaser
IALI : a model of airway epithelium derived from iPSC to study SARS-CoV-2 infection and antiviral drugs effectiveness.
Lisa MORICHON, CEMIPAI: Centre d’Etude des Maladies Infectieuses et Pharmacologie Anti-Infectieuses, CNRS UAR3725, Montpellier, France | Institute of Regenerative Medecine and Biotherapy, Université de Montpellier, CHU de Montpellier, INSERMU1183, Montpellier, France
PS1-09-Poster Teaser
Enhancing CRISPR-Cas9 Efficiency in iPS Cells Using the NanoBlades Pseudoviral Vectorization System
Ambre LELEU, SupBiotech/CEA DRF IBFJ SEPIA – SupBiotech Ecole d’Ingénieur, Villejuif, France
PS1-10-Poster Teaser
Neural organoids from progeroid and neurodegenerative Cockayne syndrome display defects correlated with the clinical condition
Tara Fournier, Molecular Mechanisms of Pathological and Physiological Ageing, Dept. of Developmental and Stem Cell Biology, CNRS UMR3738, Institut Pasteur, Paris, France | Sorbonne Université, Collège Doctoral, F-75005, Paris, France
PS1-11-Poster Teaser
Distinct dynamics of muscle stem cell subtypes associated with the hyperplasia decline in trout
Sabrina Jagot, INRAE, UR1037 Laboratory of Fish Physiology and Genomics, Rennes, France | INRAE, Oniris, PAnTher, UMR 703, Oniris, Nantes, France
PS1-12-Poster Teaser
A self-sustained quiescence muscle stem cell niche triggered by Notch signalling.
Eleni Chrysostomou, Mondor Institute, Université Paris-Est Créteil, INSERM, Créteil, France
PS1-13-Poster Teaser
Stem cell niche plasticity in acute myeloid leukemia
Lakshmi Sandhow, 1Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden | Leukemia and Niche Dynamics Lab, Institut Cochin, INSERM U1016, CNRS UMR8104, Universite Paris Cite, Paris, France
PS1-14-Poster Teaser
From emergence to niche settling: single-cell tracing and profiling of Hematopoietic Stem Cell precursors in the zebrafish embryo
Léa Torcq, Institut Pasteur, Université Paris Cité, CNRS UMR3738, Department of Developmental and Stem Cell Biology, Paris, France | Sorbonne Université, Collège doctoral, Paris, France
PS1-15-Poster Teaser
Live imaging reveals perturbed symmetric stem cell divisions in a mouse model of Duchenne Muscular Dystrophy
Brendan Evano, Stem Cells and Development, Department of Developmental and Stem Cell Biology, Institut Pasteur, Universite? Paris Cite?, Paris, France | CNRS UMR 3738, Institut Pasteur, Paris, France
PS1-16-Poster Teaser
Combination of biomaterial and stem cell-based strategies to improve cortical repair
Annousha Devi GOVINDAN, Université de Poitiers-INSERM U1084, Laboratoire des Neurosciences Expérimentales et Cliniques (LNEC), Poitiers, France
PS1-17-Poster Teaser
IPearls: Large-scale production of pluripotent stem cell-derived liver organoids through liquid-core encapsulation
Zoé Tiprez, UMR_S 1193, INSERM/Université Paris-Saclay, Villejuif, France | Fédération Hospitalo-Universitaire (FHU) Hépatinov, Villejuif, France
PS1-18-Oral Short Talk
Deciphering microenvironment cues to maintain human notochordal cells phenotype and to drive their maturation toward adult disc cells
Julie Warin, Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France
PS1-19-Oral Short Talk
Coordination between cell specification and a cadherin switch underlies the potential of self-organization in gastruloids
Alexandre Mayran, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
PS1-20-Oral Short Talk
French Center for 3Rs: Promotion of Open Science
Athanassia Sotiropoulos, GIS FC3R, Maisons Alfort, France | Inserm U1016, Institut Cochin, Paris, France
PS1-21-Oral Short Talk
Shaping the neuroinflammatory environment to promote retinal regeneration
Patrick Pla#, Paris-Saclay Institute of Neuroscience, CNRS, Université Paris-Saclay, 91400, Saclay, France
PS1-22-Poster Presentation
Vascularized bone marrow-on-chip to study stem cell niche aberration in hematopoietic diseases
Diana Passaro, Leukemia and Niche Dynamics Lab, Institut Cochin, INSERM U1016, CNRS UMR8104, Universite Paris Cite, France., Paris, France
PS1-23-Poster Presentation
Efficient single-cell cloning of gene-edited human iPSCs in low volumes
Ann Na Tan, University of Oxford, Oxford, United Kingdom
PS1-24-Poster Presentation
Development of a reinnervated model of human skin with sensory neurons-like obtain from skin derived precursors
Ophélie PIERRE, Laboratory Interactions Neurons Keratinocytes (LINK), Brest, France
PS1-25-Poster Presentation
Innovative imaging of organoids enables new analyzes
Anne GAIGNERIE, Nantes Université, CHU Nantes, CNRS, Inserm, BioCore, FR-44000, Nantes, Nantes, France
PS1-26-Poster Presentation
Development and characterization of retinal organoids derived from human induced pluripotent stem cells.
Amaury Pénaguin, Université de Poitiers - INSERM U1084, Laboratoire des neurosciences expérimentales et cliniques (LNEC) - Equipe Thérapies cellulaires dans les pathologies cérébrales, Poitiers, France | Laboratoires Théa, Clermont-Ferrand, France
PS1-27-Poster Presentation
Mechanisms of human digestive tract regionalization during embryonic development
Lola Bonneau, Inserm UMR 1235 - TENS, Nantes Université, Inserm, 1 Rue Gaston Veil, 44035, Nantes, France
PS1-28-Poster Presentation
Mechanism and regulation of lumen remodelling in the zebrafish developing spinal cord
Amina Medyouf, Developmental Biology Laboratory, Institute of Biology Paris-Seine, Sorbonne University, CNRS, Paris, France
PS1-29-Poster Presentation
Generation and genetic engineering of human iPS cells: services from the Cell Engineering and Vectorology Core Facility at the Paris Brain Institute (ICM Paris)
Clémentine RIPOLL, Paris Brain Institute, Paris, France
PS1-30-Poster Presentation
Human engineered skeletal muscles derived from iPSC for the modeling of neuromuscular disorders and the development of a screening cellular platform
Anaïs Bleuzen, Univ Paris Est Créteil, INSERM, EFS, IMRB, F-94010, Créteil, France
PS1-31-Poster Presentation
Gastruloids as an in vitro model to study Cardiopharyngeal Mesoderm Specification : Insights from Single-Cell RNAseq and Single Molecule FISH Experiments
Laurent Argiro*, Aix Marseille Universite, Inserm, MMG U1251 *These authors contributed equally to this work. ** co-last authors., Marseille, France
PS1-32-Poster Presentation
Cerebral organoid as a tool to evaluate the neural opioid toxicity
Théo La Rosa, Univ Lyon, Université Lyon 1, INSERM, INRAE, U1208, USC1361, Institut de recherche sur les cellules souches et le cerveau, Bron, France
PS1-33-Poster Presentation
Decoding the Contribution of Microtubule Network Organization in Cardiac Muscle Cell Functioning using Human iPSC derived Cardiomyocytes
Tanushri Dargar, Institut NeuroMyoGène, CNRS UMR 5261 -INSERM U1315, University of Lyon - University Claude Bernard Lyon 1, Lyon, France
PS1-34-Poster Presentation
Adaptability of the Golgi-dependent protein secretory routes
Gaelle Boncompain, Institut NeuroMyoGene, Lyon, France
PS1-35-Poster Presentation
Biocompatible polymers supporting retinal pigment epithelial cell growth as part of a solution to struggle against retinal degeneration
Natacha Perrin, Centre de Nanosciences et de Nanotechnologies (C2N), CNRS UMR 9001, Université Paris-Saclay, Palaiseau, France | Centre d’Etude des Cellules Souches, Corbeil-Essonnes, France | INSERM U861, I-Stem, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Corbeil-Essonnes, France | U861, I-Stem, AFM, Université Paris-Saclay, Université d’Evry, Corbeil-Essonnes, France
PS1-36-Poster Presentation
Modeling the neuromuscular system using stem cells
Coudert Laurent, INMG-PGNM, Lyon, France
PS1-37-Poster Presentation
An Optimized and Versatile Small Molecule-based Cell Supplement for Stress Reduction in Primary and PSC-Derived Neural Cells
Christoph Hoefer, Thermo Fisher Scientific, Villebon-sur-Yvette, France
PS1-38-Poster Presentation
Induced pluripotent stem cell-derived islet organoids (i-Langerhanoids)-on-chip
Mahira Mehanović, University Grenoble Alpes, CEA, IRIG, Biomics, Inserm, Grenoble, France
PS1-39-Poster Presentation
Serotonin receptor 5-HT2C signaling activity is required for morphogenesis of neural crest derived tissues in Xenopus laevis embryos           
Alex Pae, Touro University California, Vallejo, United States
PS1-40-Poster Presentation
Induced human pluripotent stem cells to improve diagnosis of SHH-dependent midline brain defects
Veranika PANASENKAVA, Univ Rennes, CNRS, IGDR (Institut de Génétique et Développement de Rennes) - UMR6290, F-35000, Rennes, France
PS1-41-Poster Presentation
Montpellier Organoid Platform (POM)
Isabelle Peiffer, IGH, Institut de Génétique Humaine; UMR9002, CNRS, Université de Montpellier, montpellier, France | Biocampus, University of Montpellier, CNRS, INSERM, Montpellier, France
PS1-42-Poster Presentation
The role of RNASE1 in lung metastatic niche establishment by breast cancer cells
qianwen zhu, Institut Curie, Orsay, France
PS1-43-Poster Presentation
Three-dimensional Genome Architecture in Cardiac Muscle Cells: Pathophysiological Implications in Dilated Cardiomyopathy Caused by LMNA gene mutations
Marie Kervella, PhyMedExp, University of Montpellier, INSERM, CNRS, Montpellier, France | Center of Research in Myology, Institute of Myology, Sorbonne University, INSERM UMRS974, Paris, France
PS1-44-Poster Presentation
Modeling the glioblastoma tumor niche in complex cerebral organoids
Jérémy RAGUIN, Stabilité Génétique Cellules Souches et Radiations UMRE008, Université de Paris Université Paris-Sud U1274, INSERM LRP/SDRR/iRCM/JACOB/DRF, CEA, fontenay-aux-roses, France
PS1-45-Poster Presentation
Using human iPSC derived microglia to study the function of the human specific nicotinic receptor subunit, CHRFAM7A, in-vitro and in-vivo.
Michiel Van der Zwan, Institut Pasteur, Université Paris Cité, Unité de Neurobiologie Intégrative des Systèmes Cholinergiques, CNRS UMR 3571, Paris, France | Collège Doctoral, Sorbonne Université, Paris, France
PS1-46-Poster Presentation
A new human brain organoid-on-chip model meeting biological and industrial requirements of neurological preclinical studies
Héloïse Castiglione, SupBiotech/CEA-IBFJ-SEPIA, Fontenay-aux-Roses, France | SupBiotech, Ecole d’ingénieurs en Biotechnologies, Villejuif, France | NETRI, Lyon, France
PS1-47-Poster Presentation
Elucidating the Impact of Gut Microbial Factors on Lysosomal Parkinson’s Disease: Insights from Induced Pluripotent Stem Cell-Derived 2D and Organoid Models
Christin Weissleder, Mechanisms and therapy of genetic brain diseases, Institut Imagine, Paris, France | Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, United States
PS1-48-Poster Presentation
Human induced pluripotent stem (iPS) cell-derived microglia-like cells to study the roles of microglia in Alzheimer’s disease
Coralie Clua Provost, Institute for Neurosciences of Montpellier (INM), Univ Montpellier, INSERM, Montpellier, France | Institute of Functional Genomics (IGF), Univ Montpellier, INSERM, CNRS, Montpellier, France
PS1-49-Poster Presentation
Laser-Assisted Bioprinting of iPSCs generates embryoid bodies that can be differentiated to a neuronal lineage
Deepshika Arasu, Poieits, Pessac, France | University of Barcelona, Barcelona, Spain
PS1-50-Poster Presentation
Neuropathological features of Gaucher disease in Microgliacontaining Cerebral organoids
Karine Sii-Felice, LCSAT - Unité Mixte de Recherche 1184, Institut de Biologie François Jacob CEA Paris Saclay, Fontenay aux Roses, France
PS1-51-Poster Presentation
Alström Syndrome modeling based on human pluripotent stem cells as a tool to understand the visual symptoms of the disease
Elie FRANK, INSERM U861, I-Stem, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Corbeil-Essonnes, France | U861, I-Stem, AFM, Université Paris-Saclay, Université d’Evry, Corbeil-Essonnes, France
PS1-52-Poster Presentation
Characterization of FA iPSC-derived DRG organoid to decipher neurodevelopmental and neurodegenerative mechanisms
Valentine Mosbach, Institut NeuroMyoGene, PGNM UMR5261, INSERM U1315, Université Claude Bernard Lyon I, Lyon, France
PS1-53-Poster Presentation
TBC1D32 gene mutation provokes retinal pigment epithelium ciliopathy and photoreceptor anomalies
Daria Mamaeva, Institute for Neurosciences of Montpellier, University of Montpellier, Inserm, Montpellier, France, Montpellier, France
PS1-54-Poster Presentation
Using mouse and human spinal organoids to unravel molecular mechanisms underlying CNS malformations caused by primary cilia deficiency
Aline Stedman, Sorbonne Université, Institute of Biology Paris-Seine, CNRS UMR 7622 – Developmental Biology Laboratory., PARIS, France
PS1-55-Poster Presentation
Investigating Parkinson’s Disease-associated Alpha-Synuclein Pathology in Midbrain Organoids
Federico Bertoli*, Institut Imagine, INSERM UMR1163 Paris Cite’ University, 24 boulevard du Montparnasse, 75015, Paris, France, Paris, France | Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA, Chevy Chase, United States
PS1-56-Poster Presentation
Characterization of irradiated colonic stroma for therapeutic treatment of Pelvic Radiation Disease
Martin Jestin, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France
PS1-57-Poster Presentation
Benefits of bronchial epithelial repair by iPSCs in COPD
Marion Nadaud, Phymedexp Laboratory, INSERM U1046, CNRS UMR 9214, Montpellier, France | University of Montpellier, Montpellier, France | MEDBIOMED, Montpellier, France | IRMB, INSERM U1183, Montpellier, France
PS1-58-Poster Presentation
The role of CXCL12 isoforms in mouse retina blood vessels roadmap
Mariana Valente, Humoral Immunology Group - Microenvironment and Immunity Unit, INSERM U1224, Université Paris Cité, Institut Pasteur, Paris, France
PS1-59-Poster Presentation
Differences in quiescence depth along the neural lineage contribute to the maintenance of adult neurogenesis in the zebrafish telencephalon.
Tanya Foley, Zebrafish Neurogenetics Unit, Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France
PS1-60-Poster Presentation
Study bone marrow vascular niche heterogeneity in acute leukemia
Iman Litchy Boueya, Leukemia and Niche Dynamics Lab, Institut Cochin, INSERM U1016, CNRS UMR8104, Université Paris Cite, Paris, France
PS1-61-Poster Presentation
Transient CripsR/Cas9-mediated gene targeting in vivo: a versatile model to systematically investigate muscle stem cell regulators
Alireza Ghasemizadeh, Biology of the Neuromuscular System Group, Mondor Biomedical Research Institute (INSERM U955), Creteil, France
PS1-62-Poster Presentation
Engineered neurogenic niche in 3D microfluidic device as novel approach to study brain aging
Léa Hamon, Unité Perception et Action, Département Neuroscience, Institut Pasteur, CNRS UMR 3571, Paris, France
PS1-63-Poster Presentation
Gene editing using CRISPR-Cas9 on Biolaminin 521 improves single cell survival and cloning, enabling consecutive differentiation of hPSCs on biorelevant matrices
Marina Castro Zalis, BioLamina AB, Stockholm, Sweden
PS1-64-Poster Presentation
IPSC-derived retinal modelling identifies TBC1D32 as a novel causative gene for retinitis pigmentosa
Vasiliki Kalatzis, INM, Inserm U1298, Montpellier, France
Tuesday, 23 January
09:00 - 10:35
Stem cell niches and regeneration I
Chair/s: Charles DURAND, Sacha DELABROUSSE
09:00
S3-01-Invited Speaker
Guiding Intestinal Stem Cell Fate
Kim Jensen, NNF Center for Stem Cell Medicine University of Copenhagen, Copenhagen, Denmark
09:25
S3-02-Oral Short Talk
Shaping the neuroinflammatory environment to promote retinal regeneration
Patrick Pla#, Paris-Saclay Institute of Neuroscience, CNRS, Université Paris-Saclay, 91400, Saclay, France
09:40
S3-03-Oral Short Talk
Pvf1-PvR-mediated crosstalk between the trachea and the gut stimulates intestinal stem cell migration and divisions during gut regeneration
Julien Colombani, University of Copenhagen - Department of Biology, Copenhagen, Denmark
09:55
S3-04-Invited Speaker
Contribution of macrophage ontogeny to health and disease
Elisa GOMEZ PERDIGUERO, Institut Pasteur, Paris, France
10:20
S3-05-Sponsor Presentation
Redefining cell line genetic characterization & QC with Optical Genome Mapping
Alicia BERTOLOTTI, Bionano, San Diego, United States
10:25
S3-06-Poster Teaser
A self-sustained quiescence muscle stem cell niche triggered by Notch signalling.
Eleni Chrysostomou, Mondor Institute, Université Paris-Est Créteil, INSERM, Créteil, France
10:26
S3-07-Poster Teaser
Live imaging reveals perturbed symmetric stem cell divisions in a mouse model of Duchenne Muscular Dystrophy
Brendan Evano, Stem Cells and Development, Department of Developmental and Stem Cell Biology, Institut Pasteur, Universite? Paris Cite?, Paris, France | CNRS UMR 3738, Institut Pasteur, Paris, France
10:27
S3-08-Poster Teaser
From emergence to niche settling: single-cell tracing and profiling of Hematopoietic Stem Cell precursors in the zebrafish embryo
Léa Torcq, Institut Pasteur, Université Paris Cité, CNRS UMR3738, Department of Developmental and Stem Cell Biology, Paris, France | Sorbonne Université, Collège doctoral, Paris, France
10:28
S3-09-Poster Teaser
Distinct dynamics of muscle stem cell subtypes associated with the hyperplasia decline in trout
Sabrina Jagot, INRAE, UR1037 Laboratory of Fish Physiology and Genomics, Rennes, France | INRAE, Oniris, PAnTher, UMR 703, Oniris, Nantes, France
10:29
S3-10-Poster Teaser
Stem cell niche plasticity in acute myeloid leukemia
Lakshmi Sandhow, 1Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden | Leukemia and Niche Dynamics Lab, Institut Cochin, INSERM U1016, CNRS UMR8104, Universite Paris Cite, Paris, France
10:30
S3-11-Poster Teaser
Combination of biomaterial and stem cell-based strategies to improve cortical repair
Annousha Devi GOVINDAN, Université de Poitiers-INSERM U1084, Laboratoire des Neurosciences Expérimentales et Cliniques (LNEC), Poitiers, France
10:35 - 11:20
Coffee Break - Exhibition - Posters
11:20 - 12:45
Stem cell niches and regeneration II
Chair/s: Leïla MAOUCHE CHRETIEN, Patrick PLA
11:20
S4-01-Invited Speaker
Hydractinia i-cells, their contribution to development and regeneration, and their exceptional genomic stability
Uri FRANK, University of Galway, Galway, Ireland
11:45
S4-02-Oral Short Talk
Perturbed stem cell function following exposure to systemic signals associated with pathologies
Barbara Gayraud-Morel, 1Stem Cells & Development, Department of Developmental & Stem Cell Biology, Paris, France | 2CNRS UMR 3738, Institut Pasteur, Paris, France
12:00
S4-03-Invited Speaker
Disentangling the microenvironment regulation for improved treatment of myeloid malignancies
Simon MENDEZ-FERRER, University of Cambridge, Cambridge, United Kingdom
12:25
S4-04-PEPR Presentation
Introduction to the Priority Research Program on Women’s Health, Couples’ Health
Jean ROSEMBAUM, INSERM, Institut Thématique BCDE, Paris, France
12:35
S4-05-PEPR Presentation
Introduction to the Priority Research Program on Biotherapies and Bioproduction of Innovative Therapies (BBTI PEPR)
Cécile MARTINAT, INSERM UMR861 Univ. Evry/Univ. Paris-Saclay, I-Stem, Corbeil-Essone, France
12:45 - 14:15
Lunch - Exhibition - Posters
13:30 - 14:15
MEET THE EDITORS
Louis Armand
13:30
MTE-01-Keynote Speaker
"MEET THE EDITORS" ROUND TABLE
Laurent DAVID, FSSCR, Paris, France
14:15 - 16:00
Sun Rise: Cancer stem cells
Chair/s: Emmanuelle CHARAFE, Julie PANNEQUIN
14:15
S5-01-Invited Speaker
Understanding the tissue specific mechanisms by which deregulated Wnt signalling transforms the colon and liver.
Owen SANSOM, CRUK Scotland Institute, Glasgow, United Kingdom
14:40
S5-02-Oral Short Talk
An early neoplasia index (ENI10), based on molecular identity of CD10 cells and associated stemness biomarkers, is a predictor of patient outcome in many cancers
Veronique Maguer-Satta, CRCL, Inserm U1052-CNRS UMR5286, Lyon, France | Centre Leon Bérard, Lyon, France
14:55
S5-03-Oral Short Talk
Common and distinct activities of EMT factors of the ZEB family in glioblastoma cancer stem cells
Inês Coutinho, Stem Cells & Neurogenesis group; i3S Institute for Research and Innovation in Health, University of Porto, Porto, Portugal
15:10
S5-04-Invited Speaker
Comparative roadmap of pluripotent reprogramming and oncogenic transformation
Aurélia HUYGHE, Cancer Research Center of Lyon, Lyon, France
15:35
S5-05-Invited Speaker
Uprooting breast tumor heterogeneity
Christophe GINESTIER, Cancer Research Center of Marseille, Marseille, France
16:00 - 16:45
Coffee Break - Exhibition - Posters
16:45 - 18:35
Embryo and pluripotency
Chair/s: Pierre SAVATIER, Robin JOURNOT
16:45
S6-01-Invited Speaker
Adjusting the timing of mammalian development
Aydan Bulut-Karslioglu, Max Planck Institute for Molecular Genetics, Berlin, Germany
17:10
S6-02-Oral Short Talk
Early germline development in Down syndrome
Camille Dion, MRC Laboratory of Medical Sciences, London, United Kingdom
17:25
S6-03-Oral Short Talk
In vitro cell competition between pluripotent stem cell lines predicts their ability to make chimeric embryos in primates
Anais Amzal, Stem-Cell and Brain Research Institute, INSERM U1208, Bron, France | Université Claude Bernard Lyon 1, Villeurbanne, France
17:40
S6-04-Invited Speaker
Integrated approaches to understand human peri-implantation development as a gateway to improve in vitro fertilization
Laurent DAVID, Nantes Université, Nantes, France
18:05
S6-05-Sponsor Presentation
C-StemTM: Unleash the mass-market potential for iPSC-derived cell therapies.
Caroline ROYER, Treefrog Therapeutics, Pessac, France
18:10
S6-06-Poster Teaser
An essential developmental role for orphan nuclear receptors
Nicola Festuccia, Epigenomics, Proliferation and the Identity of Cells Group, Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France
18:11
S6-07-Poster Teaser
Changes in fatty acid metabolism facilitate the maturation of axial progenitors in mouse gastrulae
Lahiru-Chamara Weerasinghe-Arachchige, CNRS UMR7277, INSERM U1091, Institut de Biologie Valrose, Université Cote d’Azur, Nice, France
18:12
S6-08-Poster Teaser
PI3K/AKT signalling orchestrates ICM maturation and proper epiblast and primitive endoderm specification
Adèle* Micouin, Institut Pasteur, Unit of Epigenomics, Proliferation, and the Identity of Cells, Paris, France | Institut Pasteur, CNRS UMR3738, Department of Developmental and Stem Cell Biology, Paris, France | Universite? Paris Cite?, Paris, France
18:13
S6-09-Poster Teaser
NODAL signalling is required for blastocyst development in the mouse
Futura Gattobigio*, Institut Jacques Monod, Paris, France
18:14
S6-10-Poster Teaser
Gene networks controlling functional cell interactions in the pig embryo and embryonic stem cells revealed by single-cell omics study
Hervé Acloque, Animal Genetics and Integrative Biology (GABI) Université Paris Saclay, INRAE, AgroParisTech, Jouy en Josas, France
18:15
S6-11-Poster Teaser
Establishing new immunodeficient large animal model for receiving human induced pluripotent stem cell-derived hematopoietic grafts.
Mathias Brunet-Manquat, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France | EFS Ile de France, Unité d’Ingénierie et de Thérapie Cellulaire, Créteil, France
18:16
S6-12-Oral Short Talk
Presentation of the UIC, the worldwide professional association representing the railway sector and promoting rail transport
Philippe LORAND, UIC, Paris, France
18:30 - 20:00
Posters session 2
Exhibition & Poster Hall

THE POSTERS ARE LISTED IN THE ORDER OF THE GRID NUMBERS FROM 1 TO 66

PS2-01-Poster Teaser
Changes in fatty acid metabolism facilitate the maturation of axial progenitors in mouse gastrulae
Lahiru-Chamara Weerasinghe-Arachchige, CNRS UMR7277, INSERM U1091, Institut de Biologie Valrose, Université Cote d’Azur, Nice, France
PS2-02-Poster Teaser
Gene networks controlling functional cell interactions in the pig embryo and embryonic stem cells revealed by single-cell omics study
Hervé Acloque, Animal Genetics and Integrative Biology (GABI) Université Paris Saclay, INRAE, AgroParisTech, Jouy en Josas, France
PS2-03-Poster Teaser
PI3K/AKT signalling orchestrates ICM maturation and proper epiblast and primitive endoderm specification
Adèle* Micouin, Institut Pasteur, Unit of Epigenomics, Proliferation, and the Identity of Cells, Paris, France | Institut Pasteur, CNRS UMR3738, Department of Developmental and Stem Cell Biology, Paris, France | Universite? Paris Cite?, Paris, France
PS2-04-Poster Teaser
NODAL signalling is required for blastocyst development in the mouse
Futura Gattobigio*, Institut Jacques Monod, Paris, France
PS2-05-Poster Teaser
An essential developmental role for orphan nuclear receptors
Nicola Festuccia, Epigenomics, Proliferation and the Identity of Cells Group, Department of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France
PS2-06-Poster Teaser
Skeletal muscle cell identity is sustained by specific histone variants
Joana Esteves de Lima, Université Paris-Est - INSERM U955, CRETEIL, France
PS2-07-Poster Teaser
A BMP mediated switch in PAX3/7 transcriptional activity to pattern the sensory spinal cord
Vanessa RIBES, Institut Jacques Monod, UMR7592, CNRS, Université Paris Cité, Paris, France
PS2-08-Poster Teaser
A 20 mGy-irradiation of hematopoietic stem cells leads to a permanent and heritable endoplasmic reticulum stress that compromises their number and functionality
Stéphanie MORENO, CEA, Fontenay-aux-Roses, France
PS2-09-Poster Teaser
Delineating primary cilia-mediated signaling pathway in the muscle stem cell
Anna Rausch de Traubenberg, Institut NeuroMyoGène - Physiopathologie et génétique du neurone et du muscle (INMG-PGNM), CNRS UMR5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France
PS2-10-Poster Teaser
Interconnected Dysfunction: Exploring Shared Defects in Cardiomyocytes and Neurons in Catecholaminergic Polymorphic Ventricular Tachycardia
Albano Meli, PhyMedExp - Inserm U1046 - CNRS UMR9214, Montpellier, France
PS2-11-Poster Teaser
Establishing new immunodeficient large animal model for receiving human induced pluripotent stem cell-derived hematopoietic grafts.
Mathias Brunet-Manquat, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine (CRSA), Paris, France | EFS Ile de France, Unité d’Ingénierie et de Thérapie Cellulaire, Créteil, France
PS2-12-Oral Short Talk
Common and distinct activities of EMT factors of the ZEB family in glioblastoma cancer stem cells
Inês Coutinho, Stem Cells & Neurogenesis group; i3S Institute for Research and Innovation in Health, University of Porto, Porto, Portugal
PS2-13-Oral Short Talk
In vitro cell competition between pluripotent stem cell lines predicts their ability to make chimeric embryos in primates
Anais Amzal, Stem-Cell and Brain Research Institute, INSERM U1208, Bron, France | Université Claude Bernard Lyon 1, Villeurbanne, France
PS2-14-Poster Presentation
Modeling the muscular phenotype of facioscapulohumeral dystrophy (FSHD)
Loeva MORIN, Marseille Medical Genetics, Marseille, France
PS2-15-Poster Presentation
Unveiling EOMs complexity in regeneration: the role of muscle stem cells and fibro-adipogenic progenitors
Valentina Taglietti, INSERM U955- Université Paris Est, Cretil, France
PS2-16-Poster Presentation
Muscle stem cell regulation in cancer cachexia
Melania Murolo, 1Stem Cells and Development, Department of Developmental & Stem Cell Biology, Institut Pasteur, Paris 75015, France, Paris, France
PS2-17-Poster Presentation
Microtubule detyrosination is essential for muscle stem cell function
Vincent Gache, INMG-PGNM-U1315, Lyon, France
PS2-18-Poster Presentation
Aging-like neural stem cells in depression
Soumia Abdellaoui, Institut Necker Enfants Malades, INSERM UMR-S1151, Université Paris Cité, Paris, France
PS2-19-Poster Presentation
The “StemDif Sensor Test”: a new assay to characterize the secreted stemness and/or differentiation activities of tumor-derived cancer cell lines.
Hélène Boeuf, INSERM U1026 Biotis, Bordeaux, France
PS2-20-Poster Presentation
Establishing a reference map of human peri-implantation development
Eva Moinard, Nantes Université, CHU Nantes, Inserm, CR2TI, Nantes, France
PS2-21-Poster Presentation
Investigate X-chromosome reactivation factors in female primordial germ cells by genome-wide CRISPR-Knock-out  screening
Christel Picard, CNRS-IGMM, Montpellier, France
PS2-22-Poster Presentation
The reversion of mESCs into naïve ground state does not follow a linear path.
Sylvie Rival-Gervier, Univ Lyon, Université Claude Bernard Lyon1, INSERM U1208, INRAE USC1361, Stem Cell and Brain Institute, Bron, France
PS2-23-Poster Presentation
Efficient single-cell cloning of gene-edited human iPSCs in low volumes
Ann Na Tan, University of Oxford, Oxford, United Kingdom
PS2-24-Poster Presentation
The 'iPS_PGNM' core facility
Arnaud Jacquier, Institut NeuroMyoGene - Pathophysiology and Genetics of Neuron and Muscle (INMG-PGNM), UCBL - CNRS UMR5261 - INSERM U1315, Faculté de Médecine et de Pharmacie de Rockefeller, 8 avenue Rockefeller, 69008 Lyon – France (ips-pgnm@univ-lyon1.fr), Lyon, France
PS2-25-Poster Presentation
Role of Netrin-1 signalling in human pluripotency
Agathe de Neufville, Stem cell and Brain Research Institute (SBRI), INSERM U1208, BRON, France | Université Claude Bernard Lyon 1, Lyon, France
PS2-26-Poster Presentation
Role of 2’O-ribose methylation (2’Ome) of ribosomal RNAs in early embryonic development
Jordan HEDJAM, LabEx Dev2CAN, Institut Convergence Plascan, Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR5286, Université de Lyon, Université Claude Bernard Lyon, Centre Léon Bérard, CEDEX 08, Lyon, France, Lyon, France
PS2-27-Poster Presentation
Distinct functions of Krebs cycle metabolites in modulating stem cell survival, pluripotency, and mitochondrial dynamics
Yu Chien, NTUH, Taipei, Taiwan (China)
PS2-28-Poster Presentation
Pipeline to identify important cell fate drivers during development
Simon Chevolleau, Center for Research in Transplantation and Translational Immunology (CR2TI), NANTES, France
PS2-29-Poster Presentation
Somatic and direct reprogramming of bat cells provide new cellular substrates for studying host-pathogen interactions
Bertrand PAIN, Univ Lyon, Université Claude Bernard Lyon1, INSERM U1208, INRAE USC1361, Stem Cell and Brain Institute, Bron, France., Bron, France
PS2-30-Poster Presentation
Cell identity and lineage plasticity in the lung metastatic niche
Sacha DELABROUSSE, Institut Curie, PSL Research University, CNRS UMR3348, Orsay, France | Institut Curie, Université Paris-Saclay, CNRS UMR3348, Orsay, France
PS2-31-Poster Presentation
Strategies to enhance in vivo survival of mesenchymal stromal cells upon local injection
Mathilde Bonnet des Claustres, INSERM U1163 - Imagine Institute, Paris, France
PS2-32-Poster Presentation
Mono and biallelic inactivation of Huntingtin gene in patient-specific iPS cells reveal HTT roles in striatal development and neuronal functions
Morgane Louessard, Université Paris-Saclay, CEA, Molecular Imaging Research Center, Fontenay-aux-Roses, France | b) Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives : mécanismes, thérapies, imagerie, Fontenay-aux-Roses, France | c) Université Paris-Saclay, Inserm, Univ Evry, Institut des Cellules souches pour le traitement et l'étude des maladies monogéniques, Corbeil-Essonne, France
PS2-33-Poster Presentation
A BMP mediated PAX3/7 transcriptional activity switch creates cell fates patterns in the developing spinal cord
Robin Rondon, Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France
PS2-34-Poster Presentation
Helios degradation biases human progenitor cells towards the megakaryocytic lineage, but affects platelet production
Lea Mallo, Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement Français du Sang (EFS)-Grand Est, Biologie et Pharmacologie des Plaquettes Sanguines (BPPS) Unité Mixte de Recherche (UMR)_S1225, Fédération de Médecine Translationnelle d, STRASBOURG, France
PS2-35-Poster Presentation
Study of the role of BMP signalling during Primitive Streak specification using mouse 2D Gastruloids
Gael Simon, Université Paris Cité, CNRS, Institut Jacques Monod, 75013 Paris, France | Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005 Paris, France
PS2-36-Poster Presentation
Pathophysiological studies of iPSC-derived retinal pigment epithelium from patients with choroideremia
Vasiliki Kalatzis, Institute for Neurosciences of Montpellier (INM), University of Montpellier, INSERM U1298, Montpellier, France, Montpellier, France
PS2-37-Poster Presentation
Organoids in action: An interdisciplinary approach to the social sciences (Organact) Research project funded by the National Research Agency (ANR-22-CE41-0012-02)
Fabien Milanovic, SupBiotech, Villejuif, France | Laboratoire d'Anthropologie Sociale, UMR 7130, Collège de France, EHESS, CNRS, Paris, France
PS2-38-Poster Presentation
Exploring lipid metabolism dysregulation in Charcot-Marie-Tooth disease : insights from an in vitro model of GDAP1-associated axonal CMT
Camille Scherrer, NeurIT UR 20218, GEIST Institute, Faculté de Médecine de Limoges, University of Limoges, Limoges, France
PS2-39-Poster Presentation
Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration.
Nathalie GAULT, CEA, Fontenay-aux-Roses, France
PS2-40-Poster Presentation
Feasibility of the use of Cryo-preserved Bone-marrow Mesenchymal Stromal Cells for bone regeneration
Tiffany MARIE, IMRB U955-E10, Inserm, Unité d'Ingénierie et de Thérapie Cellulaire-Etablissement Français du Sang, Université Paris-Est, Créteil, France
PS2-41-Poster Presentation
Mesenchymal stromal cell (MSC) therapy of radiation-induced cystitis
Anne-Laure Pouliet, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PSE-SANTE/SERAMED/LRMed, Fontenay-aux-Roses, France
PS2-42-Poster Presentation
Combined cellular and gene therapy to treat Primary Ciliary Dyskinesia
Carine Bourdais, IRMB, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France
PS2-43-Poster Presentation
Can CH3-M6P be a new candidate for tissue regeneration?
Fidan Huseynova*, LBN, University of Montpellier, Montpellier, France | Institute of Molecular Biology and Biotechnologies, Baku, Azerbaijan | Department of Histology, Cytology, Embryology, Azerbaijan Medical University, Baku, Azerbaijan
PS2-44-Poster Presentation
Generation of a hPSC reporter cell line using CRISPR-Cas9 to monitor keratin 5 expression during keratinocytes differentiation
Annabelle Darle, I-STEM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, Corbeil-Essonnes, France
PS2-45-Poster Presentation
The role of technology transfer in the production of a skin tissue therapy product
Tatiana SAOUDI, Centre d'Etude des Cellules Souches, Corbeil-Essonnes, France | INSERM U861, AFM, Institute for Stem cell Therapy and Exploration of Monogenic diseases, Corbeil-Essonnes, France
PS2-46-Poster Presentation
A new human brain organoid-on-chip model meeting biological and industrial requirements of neurological preclinical studies
Héloïse Castiglione, SupBiotech/CEA-IBFJ-SEPIA, Fontenay-aux-Roses, France | SupBiotech, Ecole d’ingénieurs en Biotechnologies, Villejuif, France | NETRI, Lyon, France
PS2-47-Poster Presentation
An organoid approach to study the developmental origin of cerebellar dysfunction in Joubert syndrome
Ludovica Brunetti, Sorbonne University, Laboratoire de Biologie du Développement (IBPS-LBD), Paris, France
PS2-48-Poster Presentation
IPSC-differentiation into podocytes in presence of glomerular endothelial cell line to generate in vitro glomerular filtration barrier
Guillaume Perry, Inserm, Sorbonne Université, Maladies rénales fréquentes et rares (CoRaKiD), UMRS 1155, Paris, France | CNRS, Sorbonne Université, Laboratoire de génie électrique et électronique de Paris, GeePs, Campus Pierre et Marie Curie, Paris, France
PS2-49-Poster Presentation
Development of in vitro blood-retinal barrier for disease modelling and cell therapy for retinal dystrophies using pluripotent stem cells
Walter Habeler, INSERM U861, I-Stem, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Corbeil-Essonnes, France | Centre d'Etude des Cellules Souches, Corbeil-Essonnes, France
PS2-50-Poster Presentation
Evaluating genomic integrity after CRISPR-Cas9 gene editing using Optical Genome Mapping (OGM)
Marie-Bérengère Troadec, Univesité Brest, Inserm, EFS, UMR 1078, GGB, Brest, France | Centre Hospitalier Régional Universitaire, Laboratoire de Génétique Chromosomique, Service de Génétique et Biologie de la Reproduction, Brest, France | Centre de ressources biologiques, Site cytogénétique, CHRU Brest, Brest, France
PS2-51-Poster Presentation
Alström Syndrome modeling based on human pluripotent stem cells as a tool to understand the visual symptoms of the disease
Elie FRANK, INSERM U861, I-Stem, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Corbeil-Essonnes, France | U861, I-Stem, AFM, Université Paris-Saclay, Université d’Evry, Corbeil-Essonnes, France
PS2-52-Poster Presentation
Novel role of MIXL1 in hiPSC endoderm differentiation.
Pierre Osteil, iGRED - UCA Institut de Génomique, Reproduction et Développement - Université Clermont Auvergne, Clermont-Ferrand, France | CMRI Children's Medical Research Institute, Sydney, Australia
PS2-53-Poster Presentation
I-Stem’s genome editing facility: A pipeline for the generation of engineered IPSCs dedicated to the study of rare diseases.
Sandrine Baghdoyan, I-Stem, INSERM/UEVE UMR 861, CORBEIL-ESSONNES, France
PS2-54-Poster Presentation
Functional and proliferative melanocyte-derived pluripotent stem cells: from developmental studies to clinical perspectives
Jennifer Allouche, INSERM U861, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, INSERM U861, Institute for Ste, France
PS2-55-Poster Presentation
Priming of MSC from umbilical cords: which molecules, which time for which impact ?
Théa Pignot, UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Bipôle, Vandœuvre-lès-Nancy, France
PS2-56-Poster Presentation
Impact of hypoxia and inflammation on chondrocyte differentiation of human mesenchymal stem cells
Ilaria Onorati, Chirurgie Thoracique et Vasculaire, Hôpital Avicenne, AP-HP, Bobigny, France | Hypoxie & Poumon, Inserm U1272, Université Sorbonne Paris Nord, UFR SMBH, Bobigny, France
PS2-57-Poster Presentation
Development of therapeutic strategies for Volumetric Muscle Loss repair based on innovative hydrogels associated with human MuSC or hiPSC-derived myoblasts.
Julien Mignot, Univ Paris Est Créteil, INSERM, EFS, IMRB, Créteil, France
PS2-58-Poster Presentation
Harnessing Representative Models of Charcot-Marie-Tooth Type 4C Disease through CRISPR-Cas9 Base editing strategies in Human Induced Pluripotent Stem cells
Camille Loret, NeurIT UR20218, GEIST Inst., Univ. of Limoges, Limoges, France
PS2-59-Poster Presentation
Identifying the transcriptomic landscape associated with progeroid and neurodegenerative Cockayne syndrome
Marin BILISKOV, Molecular Mechanisms of Pathological and Physiological Ageing, Dept. of Developmental and Stem Cell Biology, CNRS UMR3738, Institut Pasteur, Paris, France | Université Paris Cité, BioSPC ED562, Paris, France
PS2-60-Poster Presentation
Impact of Parkin mutations on dopaminergic neurons derived from iPSCs both in vitro and after transplantation in a mouse model of Parkinson's disease
Afsaneh Gaillard, Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM 1084, Poitiers, France
PS2-61-Poster Presentation
Transplantation of motor cortical neurons derived hipsc for traumatic brain injury: impact of the number of the cells used for transplantation.
Antoine Retho, Université de Poitiers-INSERM U1084, Laboratoire des neurosciences expérimentales et cliniques (LNEC) – Equipe Thérapies cellulaires dans les pathologies cérébrales, Poitiers, France
PS2-62-Poster Presentation
Dissecting the molecular signals of the aorta microenvironment leading to HSPC emergence
Giovanna Dainese, Institut de Biologie Paris Seine, Paris, France
PS2-63-Poster Presentation
Gene editing using CRISPR-Cas9 on Biolaminin 521 improves single cell survival and cloning, enabling consecutive differentiation of hPSCs on biorelevant matrices
Marina Castro Zalis, BioLamina AB, Stockholm, Sweden
PS2-64-Poster Presentation
Identification of pro-aging blood factors regulating neurogenesis in the depressive brain
Alejandro Hidalgo Aguilar, Institut Necker Enfants Malades, Paris, France
PS2-65-Poster Presentation
Human bone-marrow spheroids in ovo: a new model to study Acute Myeloid Leukemia
Clémence CARRON, Institut de biologie Paris seine, Paris, France
Wednesday, 24 January
09:00 - 10:45
Cell fate
Chair/s: Allison BARDIN, Léa TORCQ
09:00
S7-01-Invited Speaker
Adult heart regeneration in zebrafish
Didier STAINIER, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany
09:25
S7-02-Invited Speaker
Fate specification of glandular epithelial stem cells
Silvia FRE, Institut Curie, Paris, France
09:50
S7-03-Invited Speaker
Modeling human trunk development and associated sensory-motor circuits
Stéphane NEDELEC, Institut du Fer à Moulin, Paris, France | Inserm, UMR-S 1270, Paris, France | Sorbonne Université, Science and Engineering Faculty, Paris, France
10:15
S7-04-Oral Short Talk
Decoding the intrinsic and extrinsic molecular regulations leading to HSC generation
Laurent Yvernogeau, Institut de Biologie Paris Seine, Laboratoire de Biologie du Développement Team: Migration et différentiation des cellules souches hématopoïétiques, Paris, France
10:30
S7-05-Sponsor Presentation
Studying 3D Organoïds with Live Cell Imaging and Analysis
Fanny MARTIN, IZIBIO Tech, Paris, France
10:35
S7-06-Poster Teaser
Skeletal muscle cell identity is sustained by specific histone variants
Joana Esteves de Lima, Université Paris-Est - INSERM U955, CRETEIL, France
10:36
S7-07-Poster Teaser
A BMP mediated switch in PAX3/7 transcriptional activity to pattern the sensory spinal cord
Vanessa RIBES, Institut Jacques Monod, UMR7592, CNRS, Université Paris Cité, Paris, France
10:37
S7-08-Poster Teaser
A 20 mGy-irradiation of hematopoietic stem cells leads to a permanent and heritable endoplasmic reticulum stress that compromises their number and functionality
Stéphanie MORENO, CEA, Fontenay-aux-Roses, France
10:38
S7-09-Poster Teaser
Delineating primary cilia-mediated signaling pathway in the muscle stem cell
Anna Rausch de Traubenberg, Institut NeuroMyoGène - Physiopathologie et génétique du neurone et du muscle (INMG-PGNM), CNRS UMR5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France
10:39
S7-10-Poster Teaser
Interconnected Dysfunction: Exploring Shared Defects in Cardiomyocytes and Neurons in Catecholaminergic Polymorphic Ventricular Tachycardia
Albano Meli, PhyMedExp - Inserm U1046 - CNRS UMR9214, Montpellier, France
10:45 - 11:30
Coffee Break - Exhibition - Posters
11:30 - 12:30
Disease Modelling and Translational
Chair/s: John DE VOS, Leslie CARON
11:30
S8-01-Oral Short Talk
Development and emerging clinical data of a human pluripotent stem cell derived inhibitory interneuron candidate, NRTX-1001, for drug-resistant focal epilepsy.
yves MAURY, Neurona Therapeutics Inc., South San Francisco, United States
S8-02-Keynote Speaker
Gene therapy of Sickle cell Disease : where we stand
Marina CAVAZZANA, Hopital Necker, Paris, France | Institut Imagine, Paris, France
12:30 - 12:50
Closing Session