HPAPIs (highly potent active pharmaceutical ingredients) are potent molecules that may aid in the treatment of serious and life-threatening illnesses and disorders. At a certain time, due to their great potency, these compounds pose a risk to the production facility’s staff. On the one hand, special efforts must be taken to ensure operator safety, while on the other hand, great product quality is also necessary. Industry leaders, occupational toxicologists, and containment experts will share the most recent insights affecting the HPAPIs handling environment at our online meeting. Complex highly potent compound projects will be discussed, with a focus on safe and secure potent API processing, process development and scale-up, occupational health risks and toxicological assessment, advancements in isolators and facilities to reduce exposure risk, containment strategies and cross-contamination risk management, and more.