The Sixth International Conference on Smart City Applications is a multidisciplinary forum co-organized by the Computer Engineering Department of Karabuk University (KBÜ) in the partnership with Mediterranean Association of Sciences and Technologies (Medi-AST). Since the current situation, this year, SCA will take place as VIRTUAL / ONLINE from 27 to 29 October 2021. The event aims to bring together research scientists and engineers to discuss and exchange both experimental and theoretical results, novel designs, case studies, and trend-setting ideas in the area of smart cities. The conference covers any topic with an intersection with smart cities, including geo-smart information systems, education, healthcare, economy and digital business, building and home automation, environment and agriculture, and information technologies and computer science. The Conference encourages submission of original works presenting novel research results and new products or concepts are encouraged for submission. But also works in progress.