Meetings/Workshops on Genomics and Bioinformatics in Canada

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1.
 
Keystone Symposia: Noncoding RNAs – From Disease to Targeted Therapeutics
ID
833394
Dates
05 Feb 2017 - 09 Feb 2017
Location
Banff, Alberta, Canada
Abstract
It has become apparent over the last decade that small and long noncoding RNAs play a major role in the regulation of gene expression and disease. While much emphasis has been centered on the role of noncoding RNAs in human disease, a gap remains in utilizing this knowledge to develop target specific approaches to disrupting noncoding RNA pathways for therapeutic gain. This meeting will for the first time bring together an interdisciplinary group of basic and applied noncoding RNA scientists in an effort to translate our current understanding of noncoding RNA biology into meaningful therapeutics for many of those diseases afflicting society. To accomplish this goal, the meeting will aim to: (1) Introduce the broad genome-wide basic fabric of noncoding RNA regulation and form and function in the cell; (2) Focus on direct RNA/chromatin/DNA or RNA/protein interactions with candidate disease-relevant model systems; and (3) Highlight synthetic biological approaches to developing RNA or oligonucleotide mimics to target and/or disrupt particular disease-relevant noncoding RNA pathways. The goal of this meeting is to bring together basic and applied scientists working on noncoding RNAs in an effort to not only better understand the role noncoding RNAs play in the regulation of disease-relevant genes but also the emerging ability to utilize this knowledge to develop targeted therapeutics, an eventuality that heralds a new frontier in drug development and therapeutics.
Contact
Attendee Services;     Phone: [1+ 970-262-1230 or 800-253-0685];     Email: info@keystonesymposia.org
Topics
genetics, genomics, RNA, molecular biology, transcription
Related subject(s)
2.
 
Keystone Symposia: Protein-RNA Interactions – Scale, Mechanisms, Structure and Function of Coding and Noncoding RNPs
ID
833404
Dates
05 Feb 2017 - 09 Feb 2017
Location
Banff, Alberta, Canada
Abstract
Ribonucleic acid (RNA) binding proteins (RBPs) are rapidly being recognized as a major class of more than a thousand proteins that is widely conserved throughout eukaryotes and plays key roles in almost every aspect of RNA metabolism. RBPs interact with hundreds to thousands of coding and noncoding RNA substrates via cis-regulatory sequences or guided by associated small RNAs to form ribonucleoprotein (RNP) complexes. Increasingly, defects in the protein-RNA interactions by mutations within the regulatory proteins, RNA cis-elements or changes in protein availability or expression have led to numerous diseases. This meeting addresses critical gaps in our basic understanding of how, where and why these RNP complexes form using approaches that integrate high-throughput, massively parallel microarray, sequencing and proteomic technologies with structural biology, genomics, systems-level thinking and computational algorithms to probe RNPs at steps in the life cycle of processing both coding and noncoding RNAs. The specific aims are to: (1) Provide an opportunity and forum to gather interdisciplinary leaders in various fields to cross-fertilize a common, shared vision; (2) Introduce newcomers to the most cutting-edge methods that integrate mechanistic studies and high-throughput science; and (3) Consolidate the field moving forwards. As this unified field is relatively new, we will see shifts in current research paradigms and many opportunities should arise from interactions at this meeting.
Contact
Attendee Services;     Phone: [1+ 970-262-1230 or 800-253-0685];     Email: info@keystonesymposia.org
Topics
molecular biology, biochemistry, RNA, genetics, genomics
3.
 
Keystone Symposia - Adaptations to Hypoxia in Physiology and Disease
ID
825239
Dates
05 Mar 2017 - 09 Mar 2017
Location
Whistler, British Columbia, Canada
Abstract
Cellular responses to changes in oxygen availability have important implications for both physiology and pathophysiology, in particular in the setting of solid tumor progression. A number of hypoxia-inducible pathways have been characterized, such as the large transcriptome regulated by hypoxia-inducible factors (HIFs). However, many other oxygen-sensing pathways exist within the cell. The aim of this meeting is to disseminate up-to-date information on basic mechanisms of cellular and tissue hypoxia responses, and discuss the impact of these responses on physiology and cancer, with an emphasis on HIF-independent, but nevertheless fundamental, oxygen-sensing pathways. Outcomes of this meeting will include the dissemination of new scientific knowledge, the discussion of new methodologies, the education of graduate students and postdoctoral fellows in this discipline, and promotion of new collaborations between clinicians, basic researchers and industrial partners. This will be the eighth Keystone Symposia meeting on Hypoxia, which brings together academic, clinical and industrial researchers to enhance synergy between these groups and develop translational strategies for targeting hypoxic stress responses for therapeutic benefit.
Contact
Phone: [1 800-253-0685];     Email: info@keystonesymposia.org
Topics
hypoxia, tumor metabolism, hypoxic influences, intracellular homeostasis, tumor microenvironment, tumor stroma, tumor progression, o2 availability, stress responses
Related subject(s)

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Last updated: 19 August 2016