It is our pleasure to invite you to the 3rd Coatings and Interfaces Conference (CIC2021). Following the two very successful electronic editions of this conference series, we are pleased to announce that CIC2021 will hold its 3rd edition on a face-to-face format, allowing attendees to actively engage in discussions about the latest findings in the field. The conference will be held in Florence, Italy, a renowned heritage site and home to thousands of surface finishing companies. The event will take place on 24–26 November 2021. The impact of coatings and interfaces in technology is growing at an unprecedented pace. Energy, sustainable mobility, pollution control, critical raw materials, preservation of cultural heritage, control of materials degradation, food safety, and health science are all challenges that critically depend on our capability to engineer surfaces. The aim of the CIC2021 is to give scientists and professionals a unique opportunity to keep up with this quickly evolving field, by providing a comprehensive overview of the latest findings regarding the fundamentals and application of coatings and interfaces.