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Scientific Update Ltd.

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive foundational overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

Chemische Verfahrenstechnik,    Pharmakologie und Arzneimittelentwicklung

Scientific Update Ltd.

In this course, the basics of chemical process safety are explained, always starting from the underlying chemistry. A lot of emphasis will be put on heat and gas evolution, how they affect the inherent process safety and how they can be measured in the lab. Basic scale-up calculations for both gas and heat evolution will be explained using examples and exercises. Guidelines will be given to prevent possible issues with heat transfer at larger scale. The importance of stability data of chemicals, reaction mixtures and products will be explained, together with different tools to determine them experimentally. Background will be provided to understand and interpret the results of reaction calorimetry and thermal stability experiments. Safety aspects of upstream or downstream processes like storage and waste streams will be discussed. The safety benefits of flow chemistry will be explained, and the specific safety evaluation needed for such flow processes will be explored as well.

Scientific Update Ltd.

This short course will discuss the importance of designing simple, practical reaction quenches, work-ups and product isolations for a range of reaction and product types e.g. highly exothermic quenches, products with poor stability, removal of reagent by-products, consideration of impurities and meeting the needs of process intermediates as well as final products. The focus of this short course will be to design processes suitable for large scale operation and the importance of laboratory experimental design and execution to adequately model the large-scale process.

Scientific Update Ltd.

This is an almost unique course on the safety of chemical reactions and processes that are designed by chemists for chemists (and engineers) with the ultimate aim of helping the chemical industry reduce the number of chemical or process related incidents.

Scientific Update Ltd.

The aim of this course is to provide attendees with a good basis to work from when involved in taking development candidates to the first in human trials with a view also on some longer-term requirements. The course content will therefore focus on the necessary early phases of chemical development as would typically be required to support production of up to about 2kg using laboratory-based 20L equipment and pilot plant equipment.

Biochemie und Medizinische Chemie, Toxikologie,    Pharmakologie und Arzneimittelentwicklung

Scientific Update Ltd.

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive foundational overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

Chemische Verfahrenstechnik,    Pharmakologie und Arzneimittelentwicklung

Scientific Update Ltd.

The two day course written and presented by Dr Paul Murray a Process Chemist with extensive experience of applying DoE across a wide range of chemical reactions from reaction screening and new route development through to reaction optimisation. The Course will empower Scientists to implement DoE in their work to more efficiently improve their processes.

Scientific Update Ltd.

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive foundational overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

Chemische Verfahrenstechnik,    Industrielle Chemie und grüne Chemie

Scientific Update Ltd.

The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations. Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out.

Chemische Verfahrenstechnik,    Katalyse

Scientific Update Ltd.

This short, on-line course aims to give scientists and technologists a practical appreciation of the real-world problems to be addressed and the underlying principles that need to be understood to handle powders and other particulate materials successfully during chemical and physical processing.

Scientific Update Ltd.

Use of the proper mixing technology is often essential for successful process results. This online course considers how we can choose appropriate mixing conditions for laboratory, pilot, and commercial scale units to ensure technical success. The course begins by rooting us in some essential basics of mixing technology. With those fundamentals, we then progress through different mixing applications in increasing levels of complexity: single-phase (blending and heat transfer), multiple phase (solid-liquid, immiscible liquid, gas-liquid, and 3-phase), and mixing in competitive rate processes (reactions and crystallizations). Throughout, we look at scale-up and scale-down by using examples from industrial processes which have a variety of mixing requirements. We will discuss how to design and execute practical experiments at the small scale which can identify mixing sensitivities in a process that could be an issue on scale-up. Though primarily focusing on operations in stirred tanks, we will also discuss mixing applications in flow systems like static mixers.

Scientific Update Ltd.

Filtration and drying are the essential but unsung heroes of whole process design: this 3 x 3-hour session course will guide you through the underlying principles you need to consider to successfully implement them during product commercialisation.

Scientific Update Ltd.

After an introduction the course will cover crystallisation of compounds (including hydrates and solvates), different methods of crystallisation, polymorphism, salts and co-crystals, crystallisation of chiral compounds and classical resolution, analytical methods for studying the solid state and will finish with some case studies. Real life practical examples will be used throughout the course to exemplify the different aspects of crystallisation and polymorphism. The course will cover all aspects of the subject including crystallization of intermediates as well as final products. In addition, precipitations and amorphous solids will be covered and the differences between amorphous solids and crystalline solids will be discussed.

Scientific Update Ltd.

This online course is aimed at providing a holistic understanding of the challenges and issues associated with implementing an effective control strategy for all impurity types. It will examine key areas, specifically, impurity qualification, mutagenic impurities, elemental impurities, extractives and leachables and solvents. In each case, it will examine practical approaches through both case studies and practical exercises and in all instances provide clarity as to the current and emerging regulatory frameworks.

Scientific Update Ltd.

This seminar is designed to enhance the awareness of chemists and engineers regarding hazard issues. Utilising the expertise of the chemists and chemical engineers at DEKRA and Scientific Update, it will consider hazard control of new chemical processes throughout their development cycle: from early development through to full-scale production. Hazards can often be eliminated by appropriate choice of reagent or synthetic route at the R&D stage. Where this is not possible, techniques exist to quantify the hazards so that robust engineering solutions can he applied in production.

Scientific Update Ltd.

This popular course, designed for those with limited or no pilot plant or scale-up experience, provides a comprehensive overview of the most common problems experienced during the scale-up of laboratory batch processes, and ways to avoid or mitigate them. The difference between laboratory scale techniques and how the major unit operations are carried out in the pilot plant is a key focus of the course. Thus, along the way attendees will examine the many issues associated with raw material handling, conducting synthetic reactions, reaction workup, product crystallization, isolation and drying at the pilot plant or commercial scale.

Scientific Update Ltd.

This short course will look at the reasons why reactions don’t always scale-up as expected, using real-life examples from industry. Some theory on mixing and related topics (such as heat transfer) will be covered along with useful tips on which types of reactions are likely to cause problems.

Scientific Update Ltd.

This is a online short course which will look at reducing the burden of solvents, importance of solvent selection, and how to reduce solvent use and select solvents with a better safety and environmental profile.

Chemische Verfahrenstechnik,    Industrielle Chemie und grüne Chemie

Scientific Update Ltd.

The course objective is to enable participants to understand the fundamental science and engineering principles underlying process plant cleaning performance and will be covered over 3 x 3-hour sessions, combining extensive input from the course tutor, Britest Senior Innovation Specialist Rob Peeling, with ample opportunities for interactive discussion and exploration of common issues and shared experiences with fellow online trainees.

Scientific Update Ltd.

In this course, the basics of chemical process safety are explained, always starting from the underlying chemistry. A lot of emphasis will be put on heat and gas evolution, how they affect the inherent process safety and how they can be measured in the lab. Basic scale-up calculations for both gas and heat evolution will be explained using examples and exercises. Guidelines will be given to prevent possible issues with heat transfer at larger scale. The importance of stability data of chemicals, reaction mixtures and products will be explained, together with different tools to determine them experimentally. Background will be provided to understand and interpret the results of reaction calorimetry and thermal stability experiments. Safety aspects of upstream or downstream processes like storage and waste streams will be discussed. The safety benefits of flow chemistry will be explained, and the specific safety evaluation needed for such flow processes will be explored as well.

Scientific Update Ltd.

One of the main barriers that prevents a wider use of synthetic electrochemistry is a lack of specific training of most organic and process chemists. This course will cover the practical principles of organic electrochemistry, a wide range of synthetic applications and the strategies and experimental setups for the scale-up of electrochemical processes.

This online course will be of interest to organic chemists- both in industry and academia- and anyone interested in finding out more about this emerging new technology.

Chemische Verfahrenstechnik,    Elektrochemie, Elektrolyse und Korrosion

Scientific Update Ltd.

This course is designed for those with limited or no pilot plant or scale-up experience, provides a comprehensive overview of the most common problems experienced during the scale up of laboratory batch processes, and ways to avoid or mitigate them. The difference between laboratory scale techniques and how the major unit operations are carried out in the pilot plant is a key focus of the course. Thus, along the way attendees will examine the many issues associated with raw material handling, conducting synthetic reactions, reaction workup, product crystallization, isolation and drying at the pilot plant or commercial scale.