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Scientific Update Ltd.

The aim of this course is to provide attendees with a good basis to work from when involved in taking development candidates to the first in human trials with a view also on some longer-term requirements.  The course content will therefore focus on the necessary early phases of chemical development as would typically be required to support production of up to about 2kg using laboratory-based 20L equipment and pilot plant equipment.

Biochemie und Medizinische Chemie, Toxikologie,    Pharmakologie und Arzneimittelentwicklung

Scientific Update Ltd.

This course has been developed, and is presented, by chemical engineers and chemists who specialise in facilitating knowledge transfer and understanding between different scientific and engineering disciplines working at the R&D-manufacturing interface. As a result, it does not dwell on the derivation of mathematical formulae or equations used in chemical engineering design, but instead focuses on what other disciplines need to know about the information and data that chemical engineers require for design, scale-up and process troubleshooting.

Scientific Update Ltd.

Many forays by organic chemists into using biocatalysis in chemical synthesis stall at the initial scale-up stage. Screening and small scale (gram) reactions progress as planned, but when scaled -up, reactions stall, take more enzyme than expected, work-ups end up with emulsion issues etc. This course will look at some of the techniques and technologies ( tricks of the trade) that can help derisk scaling up biocatalysed reactions .A further barrier to the adoption of more biocatalytic reactions are production / EHS scientists who are unsure how to handle enzymes in the plant/pilot plant. the course will also look at good sources of information/data to facilitate the use of enzymes at scale.

Chemische Verfahrenstechnik,    Industrielle Chemie und grüne Chemie

Scientific Update Ltd.

Chemische Verfahrenstechnik,    Industrielle Chemie und grüne Chemie

Scientific Update Ltd.

This VIRTUAL short course has been developed, and is presented, by chemical engineers and chemists who specialise in facilitating knowledge transfer and understanding between different scientific and engineering disciplines working at the R&D-manufacturing interface. They do not dwell on the derivation of mathematical formulae or equations used in chemical engineering design, but instead focuses on what other disciplines need to know about the information and data that chemical engineers require for design, scale-up and process troubleshooting.

Scientific Update Ltd.

Participants will learn how to identify and prioritise process parameters, determine and manage risk, and implement control strategies. The use of experimental design (DoE) in QbD, the identification of potential mixing and scale-up problems, and the safe scale up of processes to pilot and manufacturing plants will also be discussed.

Chemische Verfahrenstechnik,    Pharmakologie und Arzneimittelentwicklung

Scientific Update Ltd.

This Online Short Course will look at Vapour-liquid and liquid- liquid separations and some of the essential techniques for recovering valuable products from mixtures. Rob Peeling will introduce you to what scientists need to know about chemical engineering basis behind distillation, absorption and solvent extraction.

Scientific Update Ltd.

Medicinal chemists need to understand the relationship between chemical structure and the physical properties of molecules and how this translates into compound stability and the interaction of the molecule with biological structures. These biological targets include proteins, lipids, nucleic acids and cell membranes. Interaction of the molecules with these targets affects the distribution of the compound in biological systems and modulates biological function. To do this successfully the medicinal chemist needs to be aware of how target selection is carried out and how this effects lead generation. The medicinal chemist needs knowledge of structure property relationships, the physico-chemical properties of drugs and how these molecules interact with the body– pharmacokinetics and ADME (Absorption, Distribution, Metabolism and Excretion).

Scientific Update Ltd.

Scientific Update Ltd.

This on line course aims to provide an overview of fluorination technology and synthetic methods- both traditional and state of the art- highlighting industrial application. Detailed case studies are used to provide context and workshops enable delegates to familiarize themselves with the chemistry described.

Scientific Update Ltd.

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive foundational overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications.

Scientific Update Ltd.

Based on the work of Prof John Atherton, this course provides an introduction to some of the key physical organic chemistry principles that underpin chemical process development as well as the requirement for inter-disciplinary cooperation i.e. process development chemists, chemical engineers, analytical chemists etc.

Scientific Update Ltd.

This is an Online Short Course and will look at the reasons why reactions don’t always scale-up as expected, using real-life examples from industry.

Scientific Update Ltd.

Scientific Update Ltd.

This 2 and a half day course is aimed at providing a holistic understanding of the challenges and issues associated with implementing an effective control strategy for all impurity types. It will examine key areas, specifically, impurity qualification, mutagenic impurities, elemental impurities, extractives and leachables and solvents. In each case, it will examine practical approaches through both case studies and practical exercises and in all instances provide clarity as to the current and emerging regulatory frameworks.

Scientific Update Ltd.

Use of the proper mixing technology is often essential for successful process results. This online course considers how we can choose appropriate mixing conditions for laboratory, pilot, and commercial scale units to ensure technical success. The course begins by rooting us in some essential basics of mixing technology. With those fundamentals, we then progress through different mixing applications in increasing levels of complexity: single-phase (blending and heat transfer), multiple phase (solid-liquid, immiscible liquid, gas-liquid, and 3-phase), and mixing in competitive rate processes (reactions and crystallizations). Throughout, we look at scale-up and scale-down by using examples from industrial processes which have a variety of mixing requirements. We will discuss how to design and execute practical experiments at the small scale which can identify mixing sensitivities in a process that could be an issue on scale-up. Though primarily focusing on operations in stirred tanks, we will also discuss mixing applications in flow systems like static mixers.

The Electrochemical Society (ECS)

Electrodeposition is widely being used in the fabrication of materials and devices, and most recently this technique has been successfully applied to the fabrication of various components in energy conversion systems. This course will offer the opportunity to students, researchers and practitioners with a variety of technical backgrounds to be introduced for the first time or to refresh their understanding of the fundamentals of the technique, as well as to gain a perspective of its potentials in nanostructure fabrication, with particular focus on energy conversion and storage application. In this course the attendees will gain practical knowledge of the methods and techniques used in the synthesis of catalysts for fuel cells, components for batteries and capacitors, and radiation absorbers for photovoltaic and photelectrochemical devices.

The Electrochemical Society (ECS)

This Short Course provides a foundation for understanding the general principles of LIB safety hazards and failure modes analysis. The effects of LIB chemical, electrical, thermal, and mechanical design features on safety characteristics is presented. Thermal runaway mechanisms are discussed in terms of risk factors that influence thermal runaway such as cell chemistry, battery design, operating conditions, and other factors. A special focus on LIB safety testing, implementation of industry standards, and lessons-learned from high-visibility industry LIB incidents is provided. The severity and consequences of catastrophic LIB failures is also presented with practical examples of how real-life industry LIB safety incident outcomes have been evaluated.

The Electrochemical Society (ECS)

This course covers the basic theory and application of electrochemical science. It is targeted toward people with a physical sciences or engineering background who have not been trained as electrochemists, but want to add electrochemical methods to their repertoire of research approaches. There are many fields in which researchers originally approach their work from another discipline but then discover that it would be advantageous to understand and use some electrochemical methods to complement their work.

The Electrochemical Society (ECS)

This course is intended for chemists, physicists, materials scientists, and engineers with an interest in applying electrochemical impedance techniques to study a broad variety of electrochemical processes. Attendees develop a basic understanding of the technique, sources of errors in impedance measurements, manner in which experiments can be optimized to reduce these errors, and use of graphical and regression methods to interpret measurements in terms of meaningful physical properties.

Scientific Update Ltd.

This Online short course on “Towards more sustainable synthesis” will look at techniques, strategies and tools to minimise the environmental impact of manufacturing pharma/agrochemical & fine chemical intermediates and products.

Chemische Verfahrenstechnik,    Industrielle Chemie und grüne Chemie

Scientific Update Ltd.

In this course, the basics of chemical process safety are explained, always starting from the underlying chemistry. A lot of emphasis will be put on heat and gas evolution, how they affect the inherent process safety and how they can be measured in the lab. Basic scale-up calculations for both gas and heat evolution will be explained using examples and exercises. Guidelines will be given to prevent possible issues with heat transfer at larger scale. The importance of stability data of chemicals, reaction mixtures and products will be explained, together with different tools to determine them experimentally. Background will be provided to understand and interpret the results of reaction calorimetry and thermal stability experiments. Safety aspects of upstream or downstream processes like storage and waste streams will be discussed. The safety benefits of flow chemistry will be explained, and the specific safety evaluation needed for such flow processes will be explored as well.

Chemische Verfahrenstechnik,    Industrielle Chemie und grüne Chemie

Scientific Update Ltd.

The course will demonstrate that some basic level of kinetic analysis can help optimize the reactions and make them more robust, helping you transfer efficient processes to the plant with increased confidence.

Katalyse,    Organometallchemie, Koordinationschemie

Scientific Update Ltd.

This online course will be of interest to organic chemists- both in industry and academia- and anyone interested in finding out more about this emerging new technology.

Organische Chemie und Polymere,    Elektrochemie, Elektrolyse und Korrosion

Scientific Update Ltd.

This course has been developed, and is presented, by chemical engineers and chemists who specialise in facilitating knowledge transfer and understanding between different scientific and engineering disciplines working at the R&D-manufacturing interface. As a result, it does not dwell on the derivation of mathematical formulae or equations used in chemical engineering design, but instead focuses on what other disciplines need to know about the information and data that chemical engineers require for design, scale-up and process troubleshooting.

Scientific Update Ltd.

This three-day course, written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industry, provides a comprehensive foundational overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment. The lectures are interspersed with interactive problem sessions, enabling participants to share in the problem solving and troubleshooting typically experienced during chemical development.

Scientific Update Ltd.

The Course will empower Scientists to implement DoE in their work to more efficiently improve their processes.

Scientific Update Ltd.

This 2½ day course aims to give chemists and chemical engineers a thorough practical knowledge of crystallisation processes. After an introduction the course will cover crystallisation of compounds (including hydrates and solvates), different methods of crystallisation, polymorphism, salts and co-crystals, crystallisation of chiral compounds and classical resolution, analytical methods for studying the solid state and will finish with some case studies. Real life practical examples will be used throughout the course to exemplify the different aspects of crystallisation and polymorphism. The course will cover all aspects of the subject including crystallization of intermediates as well as final products. In addition, precipitations and amorphous solids will be covered and the differences between amorphous solids and crystalline solids will be discussed.