Conférences  >  Sciences biologiques  >  Biologie  >  Allemagne

EMBL Heidelberg

This symposium is the seventh edition of a successful series started in 2013 and held biannually since, establishing itself as a must-attend fixture in the calendar for scientists working with bacteria and new technologies. The meeting covers a broad range of cutting-edge topics in microbiology, featuring diverse research. Emphasis is placed on novel approaches and technologies (from systems-based to single-cell) that drive each field or have the potential to revolutionize future research in microbiology. The meeting is always oversubscribed and manages to bring together scientists from different areas, who normally don’t meet, creating a highly interactive and dynamic atmosphere.

EMBL Events;     Email.: events@embl.de

ecSeq Bioinformatics GmbH

The purpose of this intense one-week summer course is to get a deep understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. You will be trained on understanding NGS data formats and handling potential problems/errors therein. In the summer school, we will use a real-life RNA-seq dataset from the current market leader illumina.

Events Team;     Email.: events@ecseq.com

NGS, Next-Generation Sequencing, Illumina, RNA-Seq

EMBL Heidelberg

Mechanisms that shape cellular proteomes are critical for life. This conference focuses on the process of protein synthesis, from the molecular and structural understanding of the translational machinery to its regulation, its implications in cell and organismal biology, and its alteration in disease. The regulation of mRNA translation is critical to maintaining cell homeostasis and mediates cellular responses to environmental, physiological, and pathological cues. Given the central importance of protein synthesis, it is unsurprising that dysregulation or defects in mRNA translation are widely linked to disease, including cancer, neurological or metabolic disorders, and viral infection. In recent years, technical advances have challenged hitherto established dogmas, uncovered new quality control mechanisms, expanded the breadth of translation regulators, enhanced our understanding of the dynamics of translation in living cells, and revealed unexpected interconnections with other cellular processes such as metabolism. Advances in these aspects of mRNA translation will be featured, as well as new insights into translation regulation in physiology and disease.

Charlotte Courtney;     Email.: charlotte.courtney@embl.de

EMBL Heidelberg

The fundamental question of the role of metabolism in development has seen a revival in interest over recent years, creating the need for the first edition of this workshop in 2023. This second edition is set to reunite the community two years on, and to ensure the ongoing interactions that can propel progress in developmental metabolism. In this rapidly advancing field, metabolomic methods play a crucial role in unraveling complex processes. The workshop will again aim to bring together researchers from diverse backgrounds: developmental biology, genetics, epigenetics, ecology, physics and math, to provide the developmental metabolism community with cutting-edge research and methodologies applied across scales, insights into the latest advancements in metabolomic techniques and their application to developmental biology. New for 2025 will be an increased integration of tool development and technologies and an added focus on novel metabolomic approaches.

EMBL Events;     Email.: events@embl.de

Logique mathématique et fondements,    Physique mathématique

EMBL Heidelberg

Karoline Wolkersdorfer;     Email.: karoline.wolkersdorfer@embl.de

Course overview This course will focus on the latest state-of-the-art novel library preparation protocols. We will start with experimental design, focusing on hands-on library preparation (including best practices, standards, and potential pitfalls), concluding with sequencing of libraries, bioinformatic evaluation & best practices. Multiomic data in scientific projects have become more and more important. NicE-Seq is a novel method enabling detection of open chromatin in fixed low numbers of cells without any additional instrumentation. Combining open chromatin with transcriptome information is crucial for interpretation of cellular states. Therefore, the course participants will also prepare mRNA libraries from the same cell populations. Participants will carry out a complete workflow, from isolation of DNA & RNA from fixed cells, library preparation for both applications and shallow sequencing. The course will discuss alternative novel approaches, various cell fixatives and their impact on analysis. In addition, we will cover basic bioinformatic tools required for data processing, quality control and initial data analysis. Beside the practical exercises, lectures and discussion sessions, the course will offer the opportunity to learn more about transferring the knowledge gained during the course to the participants’ home institu

EMBL Heidelberg

The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease. The symposium will bring together the leading developers of imaging methods with cutting-edge applications that illustrate how imaging can answer biological questions. We will emphasize methods that can capture the dynamics of life, spanning the whole range from molecular resolution to imaging of whole organisms. From its beginning in 2011, ‘Seeing is believing’ has embraced novel imaging technologies that open new windows for biological discovery, including single-molecule and super-resolution, light sheet and correlative light electron microscopy.

Iva Gavran;     Email.: iva.gavran@embl.de

EMBL Heidelberg

There is an increasing interest and need to analyse biomarkers in liquid biopsies, including basic research and clinical applications. Liquid biopsies have several advantages including being minimally invasive, allowing repeated sampling and sampling is often clinical routine. This course will provide an overview of the several techniques to detect and analyse liquid biopsy-based analytes such as circulating tumour cells, cell-free tumor-DNA (ctDNA), miRNA, extracellular vesicles, mRNA, carbohydrates and proteins. Participants will be introduced to all aspects ranging from proper sampling through analyte analysis and final data analysis. Experimentally, we will demonstrate ultrasensitive ctDNA analysis using sequencing and digital PCR. In addition, targeted miRNA profiling and flow cytometry with single-cell analysis will be highlighted. We will cover aspects of other analytes by lectures and we will have a strong focus on applications, especially cancer applications. Aspects of biobanking and clinical implementation will also be highlighted.

EMBL Events;     Email.: events@embl.de

EMBL Heidelberg

The regulation of the transcriptome is key to cellular processes that underpin cell biology, development and tissue function. All classes of cellular RNA are subject to post-transcriptional modification, be it by direct chemical modification, editing or non-templated nucleotide additions. Now in its fourth edition, the ‘Epitranscriptome’ meeting first held at EMBL in 2016 (and repeated in 2018 then in 2022 as a virtual conference) was the first RNA modification-dedicated meeting with the focus on mammalian systems. It is now established that biochemical modifications of nucleotides regulate RNA metabolism, modulate cell functions and contribute to severe human diseases including cancer and metabolic disorders. Moreover, the power of single, chemically modified nucleotides to alter the electrostatic charge, base pairing and stability of RNA molecules is exploited for clinical use of stable artificial RNA transcripts such as mRNA vaccines or synthetic small RNA molecules to increase or decrease the expression of therapeutic proteins.

EMBL Events;     Email.: events@embl.de

EMBL Heidelberg

Flow cytometry is a highly effective method for analysing individual cells that has become widely used in the fields of life sciences and medicine. By utilising flow cytometry, researchers can accurately identify and measure specific cell populations within complex mixtures, as well as assess cell cycle progression, proliferation status, and expression of fluorescent markers. Our course aims to provide a comprehensive understanding of the underlying principles of flow cytometry, while also emphasising practical considerations related to the most frequently used assays. Through a combination of theoretical instruction and hands-on training, students will gain the knowledge and skills necessary to effectively design, execute, and interpret flow cytometry experiments.

EMBL Events;     Email.: events@embl.de

EMBL Heidelberg

The nucleus lies at the literal and figurative heart of the cell – as the one organelle that all eukaryotes share, it is over 2 billion years old and integrated with every aspect of cellular function, from mechanosensing and genome regulation to membrane trafficking and cell division. Although the role of the nucleus in organising, housing and protecting the genome frequently takes centre stage, much remains to be discovered about the cellular physiology of this unique organelle studied in its own right rather than just as a passive scaffold for chromatin. This meeting will bring together a group of scientists spanning the fields of biochemistry, membrane trafficking, cytoskeletal dynamics, cell division control and cellular biophysics to address the cellular roles of the nuclear compartment from a diversity of angles.

EMBL Heidelberg

The rapid evolution of computational structural biology, driven by AI, continues to revolutionise our understanding of biomolecular structures, functions, and interactions. This follow-up to the 2023 first edition of the workshop responds to the field’s swift advancements and the pressing need for a forum that not only aligns with these progresses but also foresees future shifts. The conference aims to advance computational structural biology, promote the adoption of innovative methodologies, and enhance interdisciplinary research and collaborations. Capturing the latest advancements in this vibrant field, this second edition of the meeting is set to provide a pivotal platform for disseminating these breakthroughs and charting future directions in computational structural biology.

EMBL Events;     Email.: events@embl.de

EMBL Heidelberg

This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies. The course will be split into two groups (mammalian cells OR mice) based on participants’ expertise. Please note that all participants are expected to engage in all sessions. Participants should plan for approximately 1 hour extra per day for self paced learning modules.

EMBL Events;     Email.: events@embl.de

Génomique et bio-informatique,    Biologie moléculaire