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EMBL Heidelberg

The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease. The symposium will bring together the leading developers of imaging methods with cutting-edge applications that illustrate how imaging can answer biological questions. We will emphasize methods that can capture the dynamics of life, spanning the whole range from molecular resolution to imaging of whole organisms. From its beginning in 2011, ‘Seeing is believing’ has embraced novel imaging technologies that open new windows for biological discovery, including single-molecule and super-resolution, light sheet and correlative light electron microscopy.

Iva Gavran;     Email: iva.gavran@embl.de

EMBL Heidelberg

There is an increasing interest and need to analyse biomarkers in liquid biopsies, including basic research and clinical applications. Liquid biopsies have several advantages including being minimally invasive, allowing repeated sampling and sampling is often clinical routine. This course will provide an overview of the several techniques to detect and analyse liquid biopsy-based analytes such as circulating tumour cells, cell-free tumor-DNA (ctDNA), miRNA, extracellular vesicles, mRNA, carbohydrates and proteins. Participants will be introduced to all aspects ranging from proper sampling through analyte analysis and final data analysis. Experimentally, we will demonstrate ultrasensitive ctDNA analysis using sequencing and digital PCR. In addition, targeted miRNA profiling and flow cytometry with single-cell analysis will be highlighted. We will cover aspects of other analytes by lectures and we will have a strong focus on applications, especially cancer applications. Aspects of biobanking and clinical implementation will also be highlighted.

EMBL Events;     Email: events@embl.de

EMBL Heidelberg

The regulation of the transcriptome is key to cellular processes that underpin cell biology, development and tissue function. All classes of cellular RNA are subject to post-transcriptional modification, be it by direct chemical modification, editing or non-templated nucleotide additions. Now in its fourth edition, the ‘Epitranscriptome’ meeting first held at EMBL in 2016 (and repeated in 2018 then in 2022 as a virtual conference) was the first RNA modification-dedicated meeting with the focus on mammalian systems. It is now established that biochemical modifications of nucleotides regulate RNA metabolism, modulate cell functions and contribute to severe human diseases including cancer and metabolic disorders. Moreover, the power of single, chemically modified nucleotides to alter the electrostatic charge, base pairing and stability of RNA molecules is exploited for clinical use of stable artificial RNA transcripts such as mRNA vaccines or synthetic small RNA molecules to increase or decrease the expression of therapeutic proteins.

EMBL Events;     Email: events@embl.de

EMBL Heidelberg

Flow cytometry is a highly effective method for analysing individual cells that has become widely used in the fields of life sciences and medicine. By utilising flow cytometry, researchers can accurately identify and measure specific cell populations within complex mixtures, as well as assess cell cycle progression, proliferation status, and expression of fluorescent markers. Our course aims to provide a comprehensive understanding of the underlying principles of flow cytometry, while also emphasising practical considerations related to the most frequently used assays. Through a combination of theoretical instruction and hands-on training, students will gain the knowledge and skills necessary to effectively design, execute, and interpret flow cytometry experiments.

EMBL Events;     Email: events@embl.de

EMBL Heidelberg

The nucleus lies at the literal and figurative heart of the cell – as the one organelle that all eukaryotes share, it is over 2 billion years old and integrated with every aspect of cellular function, from mechanosensing and genome regulation to membrane trafficking and cell division. Although the role of the nucleus in organising, housing and protecting the genome frequently takes centre stage, much remains to be discovered about the cellular physiology of this unique organelle studied in its own right rather than just as a passive scaffold for chromatin. This meeting will bring together a group of scientists spanning the fields of biochemistry, membrane trafficking, cytoskeletal dynamics, cell division control and cellular biophysics to address the cellular roles of the nuclear compartment from a diversity of angles.

EMBL Heidelberg

The rapid evolution of computational structural biology, driven by AI, continues to revolutionise our understanding of biomolecular structures, functions, and interactions. This follow-up to the 2023 first edition of the workshop responds to the field’s swift advancements and the pressing need for a forum that not only aligns with these progresses but also foresees future shifts. The conference aims to advance computational structural biology, promote the adoption of innovative methodologies, and enhance interdisciplinary research and collaborations. Capturing the latest advancements in this vibrant field, this second edition of the meeting is set to provide a pivotal platform for disseminating these breakthroughs and charting future directions in computational structural biology.

EMBL Events;     Email: events@embl.de

EMBL Heidelberg

This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies. The course will be split into two groups (mammalian cells OR mice) based on participants’ expertise. Please note that all participants are expected to engage in all sessions. Participants should plan for approximately 1 hour extra per day for self paced learning modules.

EMBL Events;     Email: events@embl.de

Genomforschung und Bioinformatik,    Molekularbiologie