Weapons of mass destruction (WMD) continue to pose a global threat to international security. In particular, the development and proliferation of WMD may result in the danger of loss of control and the increased risk of their use in conventional, armed conflicts. The Chemical, Biological, Radiological, Nuclear and Explosives (CBRNE) threat space requires innovative and reliable methods that can be used to detect, prevent or limit the use, and interdict the transfer of WMD and associated materials. This conference will bring together leading scientists and researchers across the CBRNE WMD threat space to share and discuss new approaches and emerging science tackling the tough issues inherent in effective nonproliferation, counterproliferation and disarmament approaches. By focusing on scientific approaches, instead of policy, this conference will enable scientists from diverse disciplines to share their techniques and advances with their colleagues across the threat-science domain.