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3rd Epithelial Mesenchymal Interactions in Lung Development and Fibrosis Conference
04 oct 2024 - 07 oct 2024 • St. Julians, Malte
Organisateur:
Fusion Conferences
Résumé:
We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.
Identifiant de l'évènement:
1567038
Sujets apparentés:
2
4th Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference
07 oct 2024 - 10 oct 2024 • St. Julians, Malte
Organisateur:
Fusion Conferences
Résumé:
Defects in DNA damage repair and checkpoint control are underlying mechanisms driving tumorigenesis, since they allow for the accumulation of genetic alternations. Indeed, defects associated with these pathways are the underlying cause of several human cancer-prone syndromes. On the other hand, defects in DNA repair and checkpoint control create vulnerabilities in cancer cells that can be targeted by DNA damaging agents and inhibitors that disrupt checkpoint pathways. More recently, defective DNA repair and checkpoint regulation have been shown to influence R-loop formation, replication fork stability, and innate immunity. These new findings not only reveal additional mechanisms contributing to tumorigenesis, but also provide new targets for cancer therapy. This conference will focus on exploring these vulnerabilities, taking advantage of the synthetic lethality concept, and targeting specific DNA repair and checkpoint pathways for cancer therapy, either alone or in combination with chemotherapy, radiation therapy, targeted therapy, and immunotherapy. This conference will bring together basic, translational and clinical investigators to discuss current and future directions, opportunities and obstacles to the development of these anti-cancer modalities and how to best translate these concepts to clinical practice.
Identifiant de l'évènement:
1567039
3
4th Epigenetics Conference
10 oct 2024 - 13 oct 2024 • St. Julians, Malte
Organisateur:
Fusion Conferences
Résumé:
Chromatin is the template of life, the carrier of genetic information and the core regulator of fundamental processes such as gene expression and stem cell fate determination. Chromatin dysfunction on the other hand can trigger various diseases, including cancer. Although chromatin structure and function and the mechanisms of disease and their diagnostic and therapeutic approaches are the subject of many meetings, conferences bringing them together are less frequent. The boundaries among these various disciplines are disappearing and meeting on "Epigenetics: from mechanisms to disease" will focus on the discussion of the role of chromatin architecture, epigenetics, stem and single cell biology in cancer and other diseases. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation, exploiting the power of genome engineering technologies, single-cell approaches, cutting edge epigenomics and imaging approaches and novel cell systems such as organoids. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches.
Date limite de soumission des résumés:
02 mai 2024
Identifiant de l'évènement:
1589800
Sujets apparentés:


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Dernière mise à jour: 27 novembre 2023