Konferenzen zum Thema Genomforschung und Bioinformatik in Deutschland

A fundamental property of genomes is their topological organisation in the 3D space of the cell nucleus. Methodological advances in microscopy and genomics have paved new ways for studying the genome architecture at unprecedented spatial resolution. Emerging evidence has uncovered basic principles of genome organisation and pointed to its key roles in gene expression, genome maintenance and human disease, yet, the genome structure-to-function relationship remains elusive. This three-day conference will bring together experts focusing on: (i) the mechanistic basis of chromatin interactions and structure, (ii) the recent advances in modeling chromosome organization and dynamics, and (iii) the contribution of nuclear organisation in health and disease.

Tel.: [+49 (0) 6131 39-21569];     Email: events@imb.de

genetics, epigenetics, chromosome structure, chromosome organisation, gene regulation, genomics, microscopy, modelling, disease, development, ageing, aging, genomic instability, cancer, neurodegenerative disease, Hi-C

RNA | Genomic & Computational Biology

Molekularbiologie,    Systembiologie und mathematische Biologie

Minimally invasive liquid biopsies have recently emerged as novel diagnostic methods which hold the promise to monitor disease progression, detect minimal residual disease, therapy resistance and potentially even early cancer detection. Participants will gain hands-on experience in the detection of cell free tumor DNA (cfDNA) using a next generation sequencing (NGS) approach that covers all four mutation classes in a single assay. Critical aspects on recent developments to increase analytical sensitivity and mitigate sequencing errors (computational error correction) will be discussed as well as annotation, interpretation, and clinical reporting of liquid biopsy tests. Lectures will cover the evaluation of ctDNA as biomarkers, clinical applications, emerging analytes for liquid biopsy and important challenges.

EMBL Events;     Tel.: [+49 6221 378 8797];     Email: events@embl.de

Possible use cases of nucleic acids in blood and plasma in clinical settings, Strategies for the construction of high quality NGS libraries from challenging cfDNA samples, In-solution hybridization based target enrichment of clinically relevant targets, Bioinformatics analysis, Annotation, interpretation of mutations and clinical reporting

Biologie,    Molekularbiologie

This symposium will bring together latest advances in the fields of genomics, microscopy and modelling to foster their integration towards a comprehensive spatial and temporal understanding of the functional four-dimensional organisation of the eukaryotic genome.

EMBL Events;     Tel.: [+49 6221 387 8797];     Email: events@embl.de

Chromosome Engineering, Gene Regulation, Modelling Genome Organisation, DNA Replication and Repair, Chromosome Segregation, Meiotic Chromosomes, Imaging and High-throughput Technologies, Chromosome Compartment

Biologie,    Molekularbiologie

The course focuses on the highly interdisciplinary topic of metagenomics. During the course, participants will receive an overview of state-of-the-art genomic technologies and bioinformatic tools. A balanced approach of lectures and practical sessions will provide a general background and the latest advancements in the field as well as its relationship with other disciplines. The course will start with training the participants about experimental design and the preparation of their own metagenomic libraries with soil or their (environmental) samples. The metagenomic DNA will be sequenced onsite using third generation sequencing technologies and subsequent data analysis. Thus, the students have a unique opportunity to work on the complete workflow from sample preparation to data analysis. This updated course version will also address cutting-edge single-cell microbial genomics during practical. Bioinformatics analysis is a key part of the course, where students will learn how to process data from raw sequences to the application of algorithms for analysing metagenomic datasets. Trainers will provide short lectures with follow-up hands-on exercises in order to have the participants learning and assessing their knowledge.

EMBL Events;     Tel.: [+49 6221 378 8797];     Email: events@embl.de

Experimental design, Extraction of metagenomic DNA, Construction of metagenomic libraries, Single cell microbial genomics, 3rd generation sequencing (Nanopore), Bioinformatic analysis of metagenomic data

The fruit fly Drosophila has played a leading role in the discovery and dissection of basic biological processes, uncovering general principles of development, evolution and disease. Almost a century of research has generated a powerful genetic toolbox that provides a unique arsenal of methods that can tackle almost any biological question. This, combined with exciting new technologies developed in recent years have changed the way Drosophila research is conducted, enabling biologists to address questions that were impossible to study before.

EMBL Events;     Tel.: [+49 6221 378 8797];     Email: events@embl.de

The main objective of this conference is to bring people together from diverse disciplines to exchange ideas, promote cross-disciplinary collaborations and to form a synthesis of appropriate systems-level approaches. The meeting is therefore purposely broad to cover all aspects of genomics to systems biology, a unique combination that is highly appreciated by the participants. Over the past decade, this EMBL conference has therefore served as an important venue in helping to shape the field, or to be more precise to help generate a community of scientists that come from very diverse disciplines, each with the common goal to understand the systems level properties of their system of interest.

EMBL Events;     Tel.: [+49 6221 378 8797];     Email: events@embl.de

Transcription, Chromatin and nucleosomes, 3D structure, Epigenetics, Post-transcriptional regulation and non-coding RNA, Proteomics, Protein-protein interaction networks, Metabolites, Genetic interaction networks, Single cell variation, Biological noise, Systems genetics, Genotype to phenotype, Human genome variation, Data integration, modelling and prediction

Biologie,    Systembiologie und mathematische Biologie

The analysis of single cells advances research in many fields. To properly deal with such minute amounts of sample, each step of the workflow is critical, from sampling to data analysis. Additionally, the integration of data from different approaches is becoming increasingly important to capture the whole picture. This course will cover established techniques from sampling through sequencing, protein analysis and data analysis. Samples will be collected via flow cytometry, gene expression will be analysed by qRTPCR and next generation sequencing, and protein analysis will be performed by proximity extension assays. In addition, alternative methods for the whole workflow will be covered in interactive sessions of lectures and Q&A with key experts in the field. Data collected by the different methods will be analysed during in-depth sessions, which are a strong component of the course.

EMBL Events;     Tel.: [+49 6221 378 8797];     Email: events@embl.de

Single cell isolation with FACS, Single-cell genomics using Strand-Seq, Single-cell epigenetics using bisulfite sequencing, Microdroplet-based single-cell transcriptomics, Single cell NGS data analysis

Analysis,    Molekularbiologie