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Schloss Dagstuhl - Leibniz-Zentrum für Informatik

At the Dagstuhl Seminar on RNA Regulation and Multidimensional Transcriptomics, we will delve into the intersection of computational biology, deep learning, and RNA research. The event will explore how cutting-edge AI technologies are reshaping our understanding of RNA-based gene regulation and its role in health and disease.

Neuronale Netze und Künstliche Intelligenz, Maschinelles Lernen,    Implementierung und Anwendungen von künstlicher Intelligenz

Schloss Dagstuhl - Leibniz-Zentrum für Informatik

The progress in understanding genes and genomes has given a boost to the use of synthetic DNA for biological and technological applications. Synthetic nucleic acids play a central role in synthetic biology and in emerging therapeutic paradigms, e.g., genome editing and nucleic acid vaccines. DNA-based data storage is making significant progress, and thanks to its extreme data-density, its high durability and its timelessness, it is promising to be the next standard for data archival systems. Synthetic biology and the use of synthetic DNA for information storage applications bring important algorithmic and data analysis challenges. In synthetic biology, reagent and assay design are often driven by algorithmic approaches. Novel synthesis technologies offer cost-reduction by several orders of magnitude at the cost of increased error-rate, raising new coding-theoretic questions. This Dagstuhl Seminar aims to bring together leading biologists, chemists, engineers, computer/data scientists, and theoreticians working on synthetic biology and on DNA-based data storage, to enable joint work in small groups leading to discussing and exploring recent advancements and current challenges.

Molekularbiologie,    Systembiologie und mathematische Biologie

EMBL Heidelberg

Computation is an integral part of today’s research as data has grown too large or too complex to be analysed by hand. An ever-growing fraction of science is performed computationally and many wet-lab biologists spend part of their time on the computer. Many scientists struggle with this aspect of research as they have not been properly trained in the necessary set of skills. The result is that too much time is spent using inefficient tools when progress could be faster. This course provides training in several key tools, with a focus on good development practices that encourage efficient and reproducible research computing.

Email: iva.gavran@embl.de

Data Analysis, Bioinformatics, Genome Biology, Transcription, Translation, #EMBLSoftwareCarpentry

ecSeq Bioinformatics GmbH

The Single-Cell RNA-Seq Workshop is designed to provide a thorough introduction to the analysis of single-cell RNA sequencing data. Through a combination of lectures and hands-on exercises, participants will learn how to process, analyze and integrate single-cell data using industry-standard tools and techniques. Topics covered include sequencing technologies, data quality control, preprocessing, dimensional reduction, clustering, trajectory inference, differential expression analysis, and multi-sample integration.

Events Team;     Email: events@ecseq.com

Bioinformatics, NGS, Next-Generation Sequencing, single-cell RNA-seq

EMBL Heidelberg

Regulation of translation is key in the control of gene expression, playing a critical role in many biological and pathophysiological settings. In the last decade, methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes, however, the systems-wide analysis of translation remained an unsolved experimental challenge.

#EMBORiboProf, Data Analysis and Bioinformatics, Genome Biology, Transcription, Translation

EMBL Heidelberg

The 5th EMBL Partnership Conference will be held in Heidelberg from 31 March – 02 April 2025. The conference brings together EMBL and its partner institutes to enable the exchange of expertise and build new collaborations and research networks. The programme will focus on the impact of the recent advances in artificial intelligence (AI) on topics related to Health and related life science areas across 3 different sessions.

Email: inna.boesselmann@embl.de

ecSeq Bioinformatics GmbH

The purpose of this workshop is to get a deeper understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. The participants will be trained on understanding their own NGS data, finding potential problems/errors therein and finally perform their first downstream analysis (variant calling). In the course we will use a real-life NGS dataset from the current market leader illumina.

Events Team;     Email: events@ecseq.com

Next-Generation Sequencing, NGS, Illumina, variant calling

EMBL Heidelberg

This course will provide a global overview of the different metagenomic approaches to study microbial communities, covering methods for the functional search of genes, sequencing of metagenomes using the most recent technologies and in silico methods for sequence analysis.

Email: maria.bacadare@embl.de

#EMBOMetaG

EMBL Heidelberg

This course will teach the biological researchers how to analyse biological data sets using open-source software. Most of the analysis will be performed with docker4seq and rCASC packages, which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis. Docker4seq and rCASC packages use docker containers that embed demanding computing tasks (e.g. short reads mapping) into isolated containers. This approach provides multiple advantages: the user does not need to install all the software on its local server, the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used for the analysis. Computers for hands-on exercises will be provided along with demo data sets.

EMBL Events;     Email: events@embl.de

Data Analysis and Bioinformatics,

EMBL Heidelberg

Spatial biology is a rapidly evolving scientific topic with frequent and novel technological advances that have powerful application potential in the context of basic and translational research. The aim of the course is to provide participants a comprehensive conceptual introduction and intensive hands-on practical training on the main techniques of Imaging-based spatial-omics, i.e. multiplex immunofluorescence and spatial transcriptomics. We will provide a general overview of the field through lectures from scientific experts, assist the participants on how to choose and implement the right method for their scientific needs, and finally also share practical tips and experience of developing these techniques thanks to the presence of the original developers of such methods. Through hands-on practicals and computer sessions, the course will teach participants how to carry out open-source imaging-based methods for cost-effective spatial transcriptomics (hybridization in situ sequencing) and multiplex immunofluorescence (immune-SABER and IBEX).

Iva Gavran;     Email: iva.gavran@embl.de

Data Analysis and Bioinformatics, Genome Biology, Transcription, Translation, Technology, Imaging, Methods, #EMBOSpatialOmics

ecSeq Bioinformatics GmbH

The purpose of this intense one-week summer course is to get a deep understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. You will be trained on understanding NGS data formats and handling potential problems/errors therein. In the summer school, we will use a real-life RNA-seq dataset from the current market leader illumina.

Events Team;     Email: events@ecseq.com

NGS, Next-Generation Sequencing, Illumina, RNA-Seq

EMBL Heidelberg

This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies. The course will be split into two groups (mammalian cells OR mice) based on participants’ expertise. Please note that all participants are expected to engage in all sessions. Participants should plan for approximately 1 hour extra per day for self paced learning modules.

EMBL Events;     Email: events@embl.de

Biologie,    Molekularbiologie