Konferenzen  >  Biowissenschaften  >  Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

Regulation of translation is key in the control of gene expression, playing a critical role in many biological and pathophysiological settings. In the last decade, methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes, however, the systems-wide analysis of translation remained an unsolved experimental challenge. The advent of ‘ribosome-profiling’ provided the methodological basis for comprehensive transcriptome-wide analyses of translation at sub-codon resolution by the precise and high-throughput determination of ribosomal positions on mRNA. Its application in a variety of organisms yielded novel insights into protein synthesis and its dynamic regulation, significantly advancing our understanding of the post-transcriptional regulation of gene expression.

ecSeq Bioinformatics GmbH

The purpose of this workshop is to get a deeper understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. You will be trained on understanding NGS data formats and handling potential problems/errors therein. In the course we will use a real-life RNA-seq dataset from the current market leader illumina. All workshop attendees will be enabled to perform important first tasks of NGS data analysis themselves. The course layout has been adapted to the needs of beginners in the field of NGS bioinformatics and allows scientists with no or little background in computer science to get a first hands-on experience in this new and fast evolving research topic.

ecSeq Bioinformatics GmbH;     Email: events@ecseq.com

European Molecular Biology Organization – EMBO

This symposium explores the many ways by which the genome is regulated in the brain in order to support neural function and plasticity. The extraordinary complexity of the brain places unique demands on the genome: How are several hundreds of different neural types specified by the same genetic instructions? Does the genome provide information that guides their connectivity? How is neural activity regulated by and how does it affect genome output? We will explore these fundamental questions from the standpoint of transcriptional regulation and chromatin-based processes, including but not limited to histone marks and variants, chromatin topology and folding, coding and noncoding RNAs, transposable elements, and DNA modifications. The conference aims to bring together neuroscientists and experts in genome regulation. It will cover a broad range of experimental approaches and model systems, from biochemistry to single-cell genomics, from worms to human organoids. Overall, the conference will address the impact of genome regulation on unique features of the brain — its excitable nature, exquisite response to the environment and parallel processing capacity — with the longer-term vision of understanding how defective genome regulation can give rise to brain disease.

Interplay between gene regulation and neuronal activity, Genomic regulation of brain plasticity and behaviour, Chromatin variations in the brain, From one genome to many neurons: neurodevelopment and neural diversity

Molekularbiologie,    Neurologie

Fusion Conferences

Epigenetic mechanisms - including DNA and histone modifications, as well as regulation by non-coding RNAs - have pivotal roles in the nervous system. Aberrant epigenetic regulation also contributes to pathogenesis in various brain disorders. There are a number of recent ground-breaking discoveries of new features of epigenetic marks and regulation that are enriched in the nervous system, leading to an emerging new field of “neuroepigenetics”. In addition, new discoveries of modification of mRNAs and long non-coding RNAs lead to a new field of “epitranscriptomics”. This meeting will bring together experts and pioneers in studying neuroepigenetics and epitranscriptomics to provide an up-to-date and comprehensive picture of epigenetic and epitranscriptomic mechanisms in neural development, reprogramming and cell identity, plasticity, neuronal function and dysfunction. The meeting will offer opportunity for interdisciplinary interactions and future collaborations.

Molekularbiologie,    Biotechnologie

ecSeq Bioinformatics GmbH

The purpose of this workshop is to get a deeper understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. The participants will be trained on understanding their own NGS data, finding potential problems/errors therein and finally perform their first downstream analysis (variant calling). In the course we will use a real-life NGS dataset from the current market leader illumina. All workshop attendees will be enabled to perform important first tasks of NGS data analysis themselves. The course layout has been adapted to the needs of beginners in the field of NGS bioinformatics and allows scientists with no or little background in computer science to get a first hands-on experience in this new and fast evolving research topic.

ecSeq Bioinformatics GmbH;     Email: events@ecseq.com

Sequencing, NGS, Variant Calling, illumina, Next-Generation Sequencing, Bioinformatics

Fusion Conferences

While alterations to DNA underlie genome evolution and antibody diversification, genome instability drives many disorders, including cancer, developmental abnormalities, and neurodegeneration. DNA damage and other genome-threatening replication blocks are generally overcome by a number of DNA repair pathways. The choice of DNA repair pathways, specifically the reliance on error-prone vs. error-free is both intriguing and confounding. Moreover, the deregulation of repair pathway choice can trigger pathological processes. In this conference, we will discuss the delicate equilibrium of genome maintenance pathways, addressing how natural processes such as replication and transcription can threaten genome stability, how the genome can be altered in cancer, signatures of genome instability in human disease, and how cells control the inherent plasticity of their replication and repair machinery. We aim to bring together scientists from diverse fields who are interested in understanding the many processes impacting DNA metabolism and the molecular and biophysical principles that maintain the balance between genome stability and plasticity.

European Molecular Biology Organization – EMBO

Molekularbiologie,    Systembiologie und mathematische Biologie

ecSeq Bioinformatics GmbH

The purpose of the workshop is to introduce the concepts of bioinformatic pipeline development through the context of the open source Workflow Management System (WMS) Nextflow. The participants will be trained in the scripting, configuration and execution of example analysis pipelines based on current industry best-practices, and learn how to share them with other users. Finally, the participants will apply everything they have learned by implementing their own analysis pipelines from the ground up. By the end of the workshop all attendees will be enabled to build their own scalable, reproducible bioinformatic pipelines which can be run locally, on high-performance computing clusters or even in the cloud. The course layout has been adapted to the needs of beginners in the field of computational biology and allows scientists with little or no background in software development to get a first hands-on experience in this new and fast-evolving area of expertise.

ecSeq Bioinformatics GmbH;     Email: events@ecseq.com

Pipeline development, Bioinformatics, WMS, Nextflow, NGS, Next-Generation Sequencing

Biomath 2023 is devoted to recent research in life sciences based on applications of mathematics as well as mathematics applied to or motivated by biological studies. It is a multidisciplinary meeting forum for researchers who develop and apply mathematical and computational tools to the study of phenomena in the broad fields of biology, ecology, medicine, biophysics, biochemistry, pharmacokinetics, chemoinformatics, biotechnology, bioengineering, environmental science, etc.

Angewandte Mathematik (allgem.),    Systembiologie und mathematische Biologie

Since 2009 the Glyco-Bioinformatics Symposium aims at establishing a network of experts in glycochemistry, biology, bioinformatics and computer sciences. In addition, it provides a platform to discuss the latest outcomes presented by the MIRAGE Commission.

Unparalleled diversity and functionality of the glycome

Molekularbiologie,    Wissenschaftliches Rechnen und Datenwissenschaft

ecSeq Bioinformatics GmbH

The purpose of this intense one week summer course is to get a deep understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. You will be trained on understanding NGS data formats and handling potential problems/errors therein. In the summer school we will use a real-life RNA-seq dataset from the current market leader illumina. All students will be enabled to perform important first tasks of NGS data analysis themselves. The layout of the summer school has been adapted to the needs of beginners in the field of NGS bioinformatics and allows scientists with no or little background in computer science to get a first hands-on experience in this new and fast evolving research topic. In the evenings there will be social events, like a conference dinner, or a guided city tour through Berlin. These are always great networking possibilities.

ecSeq Bioinformatics GmbH;     Email: events@ecseq.com

NGS, RNA; Illumina, Next-Generation Sequencing, Sequencing, Bioinformatics, RNA-Seq Data Analysis, DNA Variant Calling

Laboratory of Support to Research in Molecular Medicine and Department of Biomedicine, Faculty of Medicine of the University of Porto

The Essential Molecular Biology course covers the fundamental principles and techniques used in experimental research in the area of Molecular Biology.

Essentially practical in nature, it aims at the learning of current genomics and proteomics techniques, as well as the acquisition of skills in laboratory experimentation required for scientific research in Biomedicine.

An exciting way to learn the essential genomics and proteomics techniques used in experimental research in biomedicine: hands-on, practical, intensive.

Tel.: [00351 220 426 779];     Email: mlsoares@med.up.pt

Molecular biology, genomics, proteomics, hands-on, laboratory work, practical

Fusion Conferences

The conference will provide the platform for researchers in the recombination and repair fields to present their new unpublished data that sheds novel insights into not only the mechanisms of DSB repair by recombination, but also the consequences of inaccurate repair leading to cancer. It is now clear that many inheritable cancers, including those linked to defects in the BRCA1 or BRCA2 genes, are caused by defects in homologous recombination. Understanding the precise mechanisms of recombinational repair is therefore critical for the development of new drugs that can target these diseases and improve human health.

Biologie,    Molekularbiologie

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Following the elucidation of the structure of DNA, it was clear that the iconic double helical structure of DNA would impact and impede the fundamental genomic transactions required for cellular life. Even after 70 years of research, novel roles for DNA topology and topoisomerase action in transcriptional control, chromosome structure, anti-viral responses and genome stability are still being uncovered. We are also still deciphering how many chemotherapeutics target topoisomerases and DNA topology impacted processes. The EMBO workshops on DNA topology and topoisomerases bring together scientists who have only recently discovered the importance of DNA topology in their specialties with long standing researchers in the field. This generates a vibrant interdisciplinary meeting, which highlights and disseminates work involving diverse and rapidly evolving approaches. This workshop highlights studies using techniques as varied as single molecule physics and structural biology, pan-genomic analysis of chromosome structure and chromatin composition and live cell single particle tracking to uncover new findings on the nature of DNA topological transactions and how they impact cellular processes.

European Molecular Biology Organization – EMBO

European Molecular Biology Laboratory | EMBL

This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies.

Molekularbiologie,    Biotechnologie

European Molecular Biology Organization – EMBO

Genome evolution represents the basis of species adaptation to changing environments and habitats. Recent breakthroughs in sequencing technologies resulted in the acquisition of complete genome information for an increasing number of animal species, propelling the field of evolutionary genomics into a new era of discovery. Yet, our limited capacity to interpret genome variation hinders our understanding on how phenotypical changes drive adaptation. This urges the development of novel strategies to reconcile genomic sequence and function, for which a proper integration of cell-specific gene programs, non-coding regulation and 3D chromatin organization becomes essential. Further, establishing causal relationships between genome mutations and phenotypes still remains a major challenge in the field. Within this context, novel synthetic biology approaches are emerging as a means to understand developmental processes in the context of evolution. The aim of this EMBO workshop is to bring together international scientists with distinct, but complementary expertises on interpreting genome variation, on mechanisms of gene regulation and on in vivo synthetic biology approaches. This allows a comprehensive overview that goes from fundamental principles encoded in genomes to their ultimate biological significance on the formation of living, evolving organisms.

This sixth PGE meeting will present a unique opportunity to meet and discuss with colleagues, get updated on the newest developments and insights in plant genome evolution, and will provide unique possibilities to network and discuss collaborations.

Domestication and Evolution of Crops; Decisive Moments and Inventions during Plant Genome Evolution; Polyploidy and Hybridization; Plant Genome Integrity; Climate Adaptation

Botanik,    Nahrungsmittelchemie und Agrarwissenschaften

The ReSOLUTE-IMI Consortium

The RESOLUTE and REsolution consortia of the Innovative Medicines Initiative of the European Union have been empowering over the last years the scientific community with novel research tools and datasets for transporters of the Solute Carrier (SLC) supergroup. In 2023, both projects are coming to an end, and we would like to finish with a big celebratory and future-looking conference: “Unlocking Transporters for Drug Discovery”. At the event expect to see presented the results and lessons learned by the RESOLUTE and REsolution consortia over the last five years. Furthermore, top international scientists interested in metabolism and its regulation, drug discovery, the function and structure of membrane proteins will be speaking.

RESOLUTE Communications Manager;     Email: contact@re-solute.eu

transporters, solute carriers, SLC, genomics, metabolomics, proteomics, systems biology, data integration, drug discovery, medicine, variants, mutants, structural biology, resources, bio-tools, cell lines, plasmids

Molekularbiologie,    Systembiologie und mathematische Biologie

Fusion Conferences

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Biologie,    Molekularbiologie

European Molecular Biology Laboratory | EMBL