Konferenzen  >  Biowissenschaften  >  Molekularbiologie

The seminar is designed to encourage interaction among participants and discussion around novel research projects, relating to the processes, which underlie dendritic functionality from the basics of synaptic signal integration to the impact, which dendritic activity has on the behavior of organisms both in health and disease. This includes a wide range of experimental and computational methods, ranging from electrophysiological recordings and imaging techniques to single cell as well as circuit modeling. To foster a vibrant, thought-provoking atmosphere, attendees are expected to participate either by presenting a poster, giving a short oral presentation or leading a discussion panel. It will also feature an international career development panel to highlight professional opportunities for young investigators.

Dendritic Processes in Single Cells and in the Living Organis

The Company of Biologists Ltd

This Workshop unites experts in human cell fate engineering and experts in the manipulation and characterisation of single cells. The goal is to fully understand the molecular steps underlying the transformation of one cellular identity into another. The cross-disciplinary selection of speakers spans the fields of cell fate engineering and emerging technologies to analyse and manipulate cells at single-cell resolution.

Direct lineage reprogramming approaches, Assessment of reprogramming inefficiency and infidelity, Engineering cells with defined identity through new methods, De novo predictions of factors and conditions for target cell type generation

European Molecular Biology Organization – EMBO

Cytoskeletal dynamics is at the core of the most essential questions in cellular neurobiology, such as mechanisms of axon growth in development and in response to injury, or mechanisms of synapse formation and stabilization. It is also a key element of intracellular transport, which is critical for axonal development and neurotrophic signaling, but which is also disrupted in many, if not all neurodegenerative diseases. Consequently, the cytoskeleton in neurons is a promising and emerging target for the development of novel therapeutic approaches to treat neurodegenerative diseases and to promote axon regeneration after traumatic injury. Recent advances in imaging, genetics and cell-molecular biology have catalyzed exciting new progress. However, fundamental questions about how neuronal cytoskeletal assembly, functions and dysfunction is orchestrated remain unanswered. In this workshop we will explore the latest findings on this exciting topic and will address several features involved in cytoskeleton function in nerve cells such its role in trafficking and transport, neuronal polarity, axonal guidance and neuronal migration.

Biologie,    Neurologie

The Dendrites Gordon Research Conference reflects the growing understanding that dendrites might play a central role in neuronal computation. It has long been understood that up to thousands of synaptic inputs can arrive at different locations along a neuron’s dendrites and that the subsequent integrative process ultimately determines that neuron’s output. Recent advances in molecular, electrophysiological, and imaging techniques have led to a new picture of dendrites, and a deeper understanding of their computational role. In many instances, the dendrites themselves can be the engines of active processes that contribute to computation at the cellular and network levels.

Molecular, Cellular and Circuit Rules Underlying Dendritic Computation

European Molecular Biology Organization – EMBO

Regulation of translation is key in the control of gene expression, playing a critical role in many biological and pathophysiological settings. In the last decade, methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes, however, the systems-wide analysis of translation remained an unsolved experimental challenge. The advent of ‘ribosome-profiling’ provided the methodological basis for comprehensive transcriptome-wide analyses of translation at sub-codon resolution by the precise and high-throughput determination of ribosomal positions on mRNA. Its application in a variety of organisms yielded novel insights into protein synthesis and its dynamic regulation, significantly advancing our understanding of the post-transcriptional regulation of gene expression.

The European Association for Cancer Research (EACR)

This meeting will provide participants with a broad view of the scope, methodologies, future directions and challenges in addition to practical approaches for molecular pathology, focusing on comprehensive genomic profiling in cancer, in research and in clinical settings. We will discuss innovative approaches for empowering the next generation of molecular pathologists from practical and educational viewpoints. Upcoming applications of multiparametric immunoanalysis, liquid biopsy and artificial intelligence in pathology will be addressed. The meeting will help participants to establish a network of interactions and to build bridges to foster cross disciplinary studies. We are preparing for the future and for the unknown discoveries still to come.

European Molecular Biology Organization – EMBO

Biologie,    Mulitimedia und Computergrafik, Spiele

European Molecular Biology Organization – EMBO

The unique glycolytic behaviour is present in nearly all cancer cell types. Cancer cells quickly adapt and reprogram glucose metabolism to meet their bioenergetic and biosynthetic requirements for growth and survival. A key to developing novel and effective cancer therapies is to tackle the complex metabolic ecosystem that cancer and stroma cells establish within the tumour microenvironment. This metabolic ecosystem ensures the high demand of energy and essential nutrients for tumour progression. Research on the distinct metabolic phenotype of cancer cells compared to normal cells is growing steadily to target metabolic vulnerabilities for new therapeutics in cancer. This India I EMBO Lecture Course will bring together eminent researchers and experts across the disciplines of cancer and molecular biology, structural biology, bioinformatics, medicinal chemistry and drug discovery, to share the recent advances, challenges, and opportunities in the field of tumour metabolism and drug discovery.

Biologie,    Onkologie

Oxford Global Conferences

Engage with esteemed pharmaceutical & biotech representatives as well as thought-leaders from academic & research institutions onsite and benefit from attending over 60 presentations. We will be welcoming onsite over 300 delegates for two days of cutting-edge scientific sessions and case studies bringing the latest biologics developments to the forefront of research.

Oxford Global Conferences;     Tel.: [+44 1865 248455];     Email: info@oxfordglobal.co.uk

Antibody-Based Molecular Engineering, Emerging Techniques for Bioanalysis & Characterisation and Quality Control Systems, Track 1: Computational Tools, AI/ML & Structural Approaches & inEngineering, Multi Specific Antibodies, Cell Engagers & Other New Modalities

European Molecular Biology Organization – EMBO

Immune cells respond in a coordinated way to protect us from harmful pathogens like viruses and bacteria. The responses are mediated largely through direct cell-cell contacts, which allow cells to exchange biochemical signals and mechanical inputs. The contribution of mechanical forces to molecular and cellular function has fascinated biologists and physicists alike for more than a decade, and in recent years it has become evident that mechanical forces are fundamental to immune cell function. This workshop aims to address the important challenge of bridging the gap between molecular and cellular scales processes driving immune cell mechanotransduction. Motivated by exciting developments in the field, this EMBO Workshop, “ImmunoBiophysics #2: From fundamental physics to understanding the immune response” will focus on the immune response from a distinctly physical and mechanical perspective, bringing together experimentalists and theoreticians coming from both the physical and life science communities. Building on the highly successful virtual “ImmunoBiophysics” workshop held in 2021, this hybrid EMBO Workshop will promote collaborations on this emerging topic and foster a new transdisciplinary perspective

Biologie,    Biophysik

European Molecular Biology Organization – EMBO

Angewandte Physik: Röntgen- und Synchrotronstrahlung, Kristallographie ,    Photochemie und Spektroskopie

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Biologie,    Berufliche Laufbahn und Management

European Molecular Biology Organization – EMBO

Ferroptosis is a regulated necrotic cell death modality which is now recognized as an evolutionary vulnerability caused by the incorporation of oxidation-prone polyunsaturated fatty acids (PUFAs) into cellular membranes. This metabolic cell death process provides the framework to understand the basic biological phenomena of how cells restrain, repair and adapt to phospholipid damage through changes in cellular plasticity. A close interplay between cellular metabolism and ferroptosis was established with phospholipid repair linked to numerous metabolic networks including amino acids, glutathione biosynthesis, NAD(P)H and PUFA metabolism, iron handling and the mevalonate pathway. Notably, this complex network has been found to be dysfunctional in different pathological contexts. This EMBO workshop will bring together scientists from different disciplines interested in the molecular mechanisms linked to ferroptosis, such as lipid signalling, redox chemistry, drug discovery, tumour biology, degenrative diseases, medicine and inflammation, and related experts in cell metabolism. This highly interdisciplinary meeting will promote the exchange of ideas and stimulate a critical assessment of the state-of-the-art between students, postdocs and leading researchers from different fields worldwide.

European Molecular Biology Organization – EMBO

The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

Biologie,    Berufliche Laufbahn und Management

European Molecular Biology Organization – EMBO

The Hedgehog morphogen pathway is a key signalling pathway in development and stem cell regulation. Hedgehog deregulation leads to developmental and neurological diseases and is a crucial driver of several cancers. The goal of this conference is to bring together experts working on the mechanism of action of Hedgehog signalling in Developmental Biology, Disease, and Signal Transduction. The meeting will focus on the recent structural, biochemical, and cell-biological studies that shed new light on the mechanisms by which the Hedgehog signal is received on target cells and the unexpected role of cholesterol as a second messenger. Moreover, the recent advances in understanding the molecular mechanisms underlying the Hedgehog morphogen biosynthesis, its release from cells into extracellular space, and the mechanisms involved in ligand reception will be discussed. We will also cover the most recent insights into Hedgehog-dependent control of cell proliferation and differentiation in processes that range from insect morphogenesis to vertebrate limb formation, neural tube development, and bone differentiation. 

Students' Representation in Vilnius University Life Sciences Center

The COINS – International Conference of Life Sciences is organised entirely by students of Vilnius University. The event gathers various people working in the life sciences field – including students and scholars. We invite you to immerse yourself into a collaborative scientific experience, discuss, learn and share your thoughts with experts, expand your network and enjoy an exciting program.

This year, more than ever before, the conference will be dominated by presentations by the world's leading scientists on the practical application of research. During the conference, we will dive into biomedicine, bioengineering, neurobiology and ecology topics. Join us!

Executive Project Manager;     Email: executive@thecoins.eu

Biomedicine, Neurobiology, Ecology, Bioengineering, Cancer treatment, Molecular biology

Biotechnologie,    Biologie

This symposium explores the many ways by which the genome is regulated in the brain in order to support neural function and plasticity. The extraordinary complexity of the brain places unique demands on the genome: How are several hundreds of different neural types specified by the same genetic instructions? Does the genome provide information that guides their connectivity? How is neural activity regulated by and how does it affect genome output? We will explore these fundamental questions from the standpoint of transcriptional regulation and chromatin-based processes, including but not limited to histone marks and variants, chromatin topology and folding, coding and noncoding RNAs, transposable elements, and DNA modifications. The conference aims to bring together neuroscientists and experts in genome regulation. It will cover a broad range of experimental approaches and model systems, from biochemistry to single-cell genomics, from worms to human organoids. Overall, the conference will address the impact of genome regulation on unique features of the brain — its excitable nature, exquisite response to the environment and parallel processing capacity — with the longer-term vision of understanding how defective genome regulation can give rise to brain disease.

Interplay between gene regulation and neuronal activity, Genomic regulation of brain plasticity and behaviour, Chromatin variations in the brain, From one genome to many neurons: neurodevelopment and neural diversity

Neurologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

The successful management of research projects is key to success in science. Understanding what project management is, when it is helpful and how to apply it in research is an important skill for scientists. This course, developed by CJ Fitzsimons—author of "International Project Management - intercultural cooperation in practice" (German language)—introduces key concepts in project management, both for planning and managing work, and for working effectively with people (including with yourself). The course is in English.

Biologie,    Berufliche Laufbahn und Management

Fusion Conferences

Epigenetic mechanisms - including DNA and histone modifications, as well as regulation by non-coding RNAs - have pivotal roles in the nervous system. Aberrant epigenetic regulation also contributes to pathogenesis in various brain disorders. There are a number of recent ground-breaking discoveries of new features of epigenetic marks and regulation that are enriched in the nervous system, leading to an emerging new field of “neuroepigenetics”. In addition, new discoveries of modification of mRNAs and long non-coding RNAs lead to a new field of “epitranscriptomics”. This meeting will bring together experts and pioneers in studying neuroepigenetics and epitranscriptomics to provide an up-to-date and comprehensive picture of epigenetic and epitranscriptomic mechanisms in neural development, reprogramming and cell identity, plasticity, neuronal function and dysfunction. The meeting will offer opportunity for interdisciplinary interactions and future collaborations.

Biotechnologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

Biologie,    Berufliche Laufbahn und Management

Fusion Conferences

While alterations to DNA underlie genome evolution and antibody diversification, genome instability drives many disorders, including cancer, developmental abnormalities, and neurodegeneration. DNA damage and other genome-threatening replication blocks are generally overcome by a number of DNA repair pathways. The choice of DNA repair pathways, specifically the reliance on error-prone vs. error-free is both intriguing and confounding. Moreover, the deregulation of repair pathway choice can trigger pathological processes. In this conference, we will discuss the delicate equilibrium of genome maintenance pathways, addressing how natural processes such as replication and transcription can threaten genome stability, how the genome can be altered in cancer, signatures of genome instability in human disease, and how cells control the inherent plasticity of their replication and repair machinery. We aim to bring together scientists from diverse fields who are interested in understanding the many processes impacting DNA metabolism and the molecular and biophysical principles that maintain the balance between genome stability and plasticity.

European Molecular Biology Laboratory | EMBL

This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms. Invited guest researchers together with microscopy experts from the EMBL will foster an intense information flow with a balance of lectures and practical workshops. The focus of the course will be on the use of fluorescence microscopy to obtain information about localisation and functions of proteins and other bio-molecules at different spatial scales.

Biologie,    Mikroskopie

European Molecular Biology Organization – EMBO

Genomforschung und Bioinformatik,    Systembiologie und mathematische Biologie

European Molecular Biology Organization – EMBO

The exploration of the cell biological aspects of nervous system development, function, and health continues delivering groundbreaking pieces of information that push forward our understanding of brain function and disease. The dynamics and localization of cellular processes and their plasticity in the face of altered conditions are emerging as key for supporting core properties of the nervous system. In this meeting, we are excited to provide a vital forum for the exchange of cutting-edge research in the broad field of neuronal cell biology, with great attention to novel techniques and emerging views. The 2023 EMBO Cell Biology of the Neuron workshop will focus on the multiple mechanisms that endow neurons with their resilience- keeping them functional for up to many years.

Biologie,    Neurologie

European Molecular Biology Organization – EMBO

Biologie,    Berufliche Laufbahn und Management

We are at the dawn of a new era of biology where we will start to understand how organisms function together and react or adapt to changes at different molecular levels. This includes the multitude of stresses that organisms are exposed to, from malnutrition and adverse climate events to many other biological, chemical and physical insults. Progress in biological analyses at both a single scale and across scales, have allowed us to further understand organisms in the context of dynamic environments. These can be environments which are changed by disease, commensal cohabitation or competition, as well as abiotic factors. With the molecular understanding we already have at the cellular and organismal levels, and new tools and quantitative approaches, this symposium will address how genotype and the environment bring about phenotypes at the population level.

Planetary biology, Microbial ecosystems, Human ecosystems, Life in context: theory, Learning from the past: paleobiology

European Molecular Biology Organization – EMBO

The discovery of myriad noncoding RNAs (ncRNAs) over the past decade has revealed a universe of new and exciting therapeutic opportunities. Many thousands of microRNAs, piRNAs, circular RNAs, long noncoding RNAs, and others are expressed across healthy and diseased human tissues and play key functional roles in pathogenic states and processes. Their regulatory roles, cell-type-specificity, and vast numbers confer on ncRNAs unique advantages as therapeutic targets. Rapid advances in clinical transcriptomics, oligonucleotide therapeutics, and RNA-directed small molecules, open the possibility for rapid, economical, and personalised ncRNA-directed therapies. Reaching this goal will require overcoming key challenges, including low evolutionary conservation in model species, poorly-characterised molecular mechanisms, finding hits amongst the vast ncRNA transcriptome, and effectively drugging targets in vivo.

Biologie,    Pharmakogenomik, Personalisierte Medizin

European Molecular Biology Laboratory | EMBL

This course will teach the biological researchers how to analyse biological data sets using open-source software. Most of the analysis will be performed with docker4seq and rCASC packages, which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis. Docker4seq and rCASC packages use docker containers that embed demanding computing tasks (e.g. short reads mapping) into isolated containers. This approach provides multiple advantages: the user does not need to install all the software on its local server, the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used for the analysis. Computers for hands-on exercises will be provided along with demo data sets.

Computerprogramme,    Wissenschaftliches Rechnen und Datenwissenschaft

European Molecular Biology Organization – EMBO

Cell polarization is an essential first step for many biological processes ranging from cell motility to tissue and organism morphogenesis. At the same time, cell polarization requires a precise control of their internal organization, which is the result of a complex dynamic interplay between the cytoskeleton, molecular motors, signaling molecules, and membranes. Recent technological advances have helped obtaining valuable new information on the different temporal and spatial scales that govern cell polarization. We have obtained structures of membrane-localized protein complexes, demonstrated the emergent self-organizing properties of proteins and cellular systems and shed light on how to modulate the shape of membranes and tissues to build entire tissues or organisms. To develop a mechanistic understanding of these processes, we need to integrate our existing knowledge on cell polarization, from the tissue level down to individual molecules, obtained from minimal reconstituted systems to whole animals, from experimental and theoretical approaches. This EMBO Workshop will bring together a highly diverse group of scientists (cell & structural biologists, (bio)chemists, experimental & theoretical physicists) to present the state-of-the-art of their fields, to exchange ideas, and to identify synergies between them to establish new collaborations and open new research fields.

European Molecular Biology Organization – EMBO

Postponed from 19 – 24 September 2021

Biologie,    Physiologie und Metabolismus des Menschen

European Molecular Biology Organization – EMBO

RNA and protein degradation play critical roles during dynamic proteome remodeling in response to developmental and environmental cues. Although RNA and protein degradation pathways have often been investigated in isolation, there is a growing interest in understanding how RNA decay and protein degradation systems interact and cooperate to shape both the RNA and protein landscape within cells and tissues. For example, an explosion of recent research has demonstrated that RNA decay and protein degradation cooperate when ribosome progression is halted to facilitate removal of potentially toxic mRNA and/or protein species. Further, regulating the abundance of either RNA or cognate RNA binding proteins can alter the behavior of highly dynamic macromolecular assembles that can form liquid-like condensates and have been linked to various human pathologies. The purpose of this EMBO Workshop is to bring together experts in the RNA decay and protein degradation fields to report on our current understanding of RNA and protein degradation pathway intersections, discover common principles, and share technical expertise on best practices to interrogate RNA or protein turnover.

European Molecular Biology Organization – EMBO

After recent advances in the field of molecular biology and genetics accompanied by the breathtaking progress in multi-omic strategies, have led to the development of Systems Biology in the last 5 years. Holistic approaches enable a refined approach to study the dynamic interactions between the components of the nucleus, the cell and its environment, ultimately leading to understanding the biological networks and the properties of biological systems. Recent advances, such as reaching the unprecedented resolution of individual cells combined with the use of new systems biology approaches, allow to address long standing questions, especially in the fields of disease and development. Thus, this EMBO Workshop will bring together world-class experts and young scientists in the fields of Systems Biology, Chromatin and Epigenetics for four full days to discuss their exciting recent findings as well as the future directions of these fields. The topics of the EMBO Workshop are sufficiently covered by the outstanding speakers. This EMBO Workshop has a unique focus and will allow all participants to receive a coherent, updated and original view of how the interplay of Systems Biology, Chromatin and Epigenetics will advance our understanding of development and disease, important areas that hold the keys for future therapeutic approaches.

European Molecular Biology Organization – EMBO

Biologie,    Berufliche Laufbahn und Management

This highly dynamic field combines theoretical, computational, biochemical, physical, and cellular approaches to understand the molecular mechanisms that shape life. The 2023 GRS meeting will focus on recent advances in these areas, which have allowed a better understanding of how proteins shape and power biology. Topics will include protein folding, binding interactions, allostery, evolution, design, cellular signaling, macromolecular organization, and more.

Combining Theory and Experiments to Understand Mechanisms of Function

Launched in 2007, this cross-disciplinary FASEB Science Research Conference (SRC) is focused on endoplasmic reticulum (ER) function and dynamics, and the contribution of ER dysfunction to disease.  The conference brings together cell biologists and disease-oriented researchers, including both trainees and independent investigators. It attracts basic researchers interested in protein folding, protein secretion, cellular stress responses, protein post-translational modification, proteasome dependent protein degradation, and regulation of lipid biosynthesis, as well as researchers focusing on a range of pathologies, including diabetes, neurodegeneration, cancer, and diseases of protein misfolding.

European Molecular Biology Organization – EMBO

Protein science is continuing a dramatic renaissance with the emergence of ever-more powerful methods of structural biology, computation, and molecular biology. The arena of practical applications of protein science continues to expand explosively. The 2023 Proteins GRC will highlight “complexity in proteins” by bringing together experimental, theoretical and computational biochemists, biophysicists, chemists, chemical biologists, biologists and bioengineers who study the diverse aspects of protein science including protein function, dynamics, thermodynamics and structure using cutting-edge techniques and strategies.

Complexity in Proteins

Oxford Global Conferences

Gene Therapy Development & Manufacturing 2023 delivers in-depth discussion on optimised process strategies and technologies for the successful technical development and manufacture of advanced gene therapy products.

Tel.: [+44 1865 248455];     Email: h.liddiard@oxfordglobal.co.uk

Gene therapy, biology, vector development, gene editing, personalised medicine

European Molecular Biology Organization – EMBO

The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

Biologie,    Berufliche Laufbahn und Management

The Royal Society of Chemistry

This 2.5 day symposium is the third in the very successful series of biannual meetings started in 2017 containing high quality international speakers from industry and academia on topics of Medicinal Chemistry and related enabling technologies. Organised by the Biological and Medicinal Chemistry Sector of the Royal Society of Chemistry, together with Nordic affiliates, the meeting promises to be an exciting and invigorating gathering packed with fantastic opportunities to disseminate knowledge and expand networks.

European Molecular Biology Organization – EMBO

The discovery of myriad noncoding RNAs (ncRNAs) over the past decade has revealed a universe of new and exciting therapeutic opportunities. Many thousands of microRNAs, piRNAs, circular RNAs, long noncoding RNAs, and others are expressed across healthy and diseased human tissues and play key functional roles in pathogenic states and processes. Their regulatory roles, cell-type-specificity, and vast numbers confer on ncRNAs unique advantages as therapeutic targets. Rapid advances in clinical transcriptomics, oligonucleotide therapeutics, and RNA-directed small molecules, open the possibility for rapid, economical, and personalised ncRNA-directed therapies. Reaching this goal will require overcoming key challenges, including low evolutionary conservation in model species, poorly-characterised molecular mechanisms, finding hits amongst the vast ncRNA transcriptome, and effectively drugging targets in vivo. This EMBO Workshop will bring together colleagues from both academic and commercial worlds to discuss their latest progress in these issues. Sessions will cover the full span from basic disease biology to therapeutic development. Confirmed speakers represent leaders from around the globe, and numerous slots have been set aside for oral presentations selected from submitted abstracts.

European Molecular Biology Organization – EMBO

This EMBO practical course aims to provide a theoretical and practical overview of state-of-the-art techniques for the characterization of various PTMs, such as phosphorylation, acetylation, cysteine PTMs and glycosylation, and their cross-talking in controlling dynamic cellular mechanisms. The laboratory part will focus on a case study of EGF stimulated SILAC labeled HeLa cells. You will be introduced to enrichment, identification and quantitation of the PTM peptides and to mass spectrometry analysis as well as data interpretation and bioinformatics. This will provide you with knowledge needed to perform quantitative large-scale PTMomics from small amounts of sample material yourself. You will be taught in methods developed in the laboratories of the speakers and they will provide you with their own tips and tricks.

European Molecular Biology Organization – EMBO

Biologie,    Berufliche Laufbahn und Management

Understanding the molecular mechanisms of gene expression regulation and their implications in drug development/medicine will be the general theme of the 2023 Nucleic Acids GRS. The meeting will also serve as a platform to discuss recent technical developments in cutting-edge microscopy and next generation sequencing methods employed by nucleic acid researchers.

Mechanism Meets Medicine

European Molecular Biology Organization – EMBO

Advanced reproductive technologies, such as intracytoplasmic sperm injection, have revolutionized reproductive medicine by enabling effective fertilization without the need to understand the cause of infertility. However, declining male fertility persists in many countries, and growing evidence suggested that the reproductive health of fathers affects their children’s health, calling for continuing investigation of the underlying mechanisms. The main themes of this EMBO Workshop are the male reproductive system, testis development, and sperm formation in mammals, including humans and animal models. Reflecting the multifaceted nature of male reproduction and discoveries made by increasingly advanced experimental techniques, the three broad topics further branch into sub-topics including genetics, epigenetics, immunity, lifestyle influences, toxicity, immunology, and endocrinology. Clinically relevant topics—semen function, sperm physiology, reproductive technologies, and fertility preservation—are also incorporated. This EMBO Workshop aims to bridge the knowledge gap in male reproduction, facilitate networking among research groups with different expertise, and promote the translation of fundamental research in male reproduction into diagnoses and therapies.

European Molecular Biology Organization – EMBO

Meiosis is a defining feature of sexual reproduction. This specialized cell division program comprises a single round of DNA replication followed by two successive cell divisions, thereby reducing chromosome number by half. This reduction accommodates the later combination of two haploid gametes during fertilization to reconstitute a full diploid genome. The unique events of meiosis, including pairwise alignment of parental chromosomes, inter-homolog recombination, kinetochore attachment, cell cycle adaptations and error correction mechanisms, are intensely studied processes in numerous model organisms (fungi, protists, plants, and animals). The Meiosis field is driven by fascination in how evolution has implemented and perfected the meiotic program, and also by its significance to both plant breeding and human health. As a special topic for the 2021 EMBO Workshop, we have chosen homolog pairing. The recognition and physical pairing of homologous chromosomes is an essential feature of meiosis, and also occurs in other contexts. It is therefore timely to bring together the fields of meiotic and post-meiotic chromosome pairing to potentially uncover common principles and mechanisms.

Unraveling the Mechanisms of Membrane Transport: Structure, Dynamics and Allosteric Regulation

European Molecular Biology Organization – EMBO

Biologie,    Systembiologie und mathematische Biologie

The Nucleic Acids Gordon Research Conference (NAGRC) is the premier meeting for exchange of new ideas about the structure and mechanistic behavior of nucleic acids and their cellular processing factors, and the potential applications of innovative developments in RNA and DNA science. Historically, the meeting has provided a powerful forum for synthesizing cutting edge information that leads to ground-breaking discoveries and world-changing technologies. An important feature of the meeting is the inclusion of late-breaking findings and the active participation of early career scientists who are at the forefront of nucleic acid science.

Structural, Functional and Mechanistic Behavior of DNA, RNA and Nucleic Acid Processing Enzymes

European Molecular Biology Organization – EMBO

Since 2009 the Glyco-Bioinformatics Symposium aims at establishing a network of experts in glycochemistry, biology, bioinformatics and computer sciences. In addition, it provides a platform to discuss the latest outcomes presented by the MIRAGE Commission.

Unparalleled diversity and functionality of the glycome

Genomforschung und Bioinformatik,    Wissenschaftliches Rechnen und Datenwissenschaft

Cambridge Healthtech Institute

The ubiquitin-proteasome, lysosome and autophagy systems are all well-controlled, selective degradation pathways that are key cellular regulators in cancer, CNS, and other diseases. A new generation of hetero bi-functional chimeras and small molecule monovalent degraders are being developed to hijack these systems for targeted protein degradation or stabilization. These molecules that include Proteolysis-targeting chimeras (PROTACs) and molecular glues are being used to seek out previously “undruggable” targets for therapeutic intervention. However, challenges do exist in terms of specificity, stability, biodistribution and penetration of these degrader molecules. This conference on Next-Generation Degraders & Glues brings together experts in the field to discuss these new therapeutic modalities, as well as issues underlying the use of targeted degradation as a new therapeutic approach.

Marketing Manager;     Email: aorktiese@healthtech.com

PROTACs, Molecular Glues, Protein Degradation

European Molecular Biology Organization – EMBO

Postponed from 21.09.2021–24.09.2021

Viruses are major human pathogens that cause a wide range of infectious diseases, representing a constantly recurring challenge to the health of individuals and the functioning of human society. Only a profound understanding of viral biology will provide the basis for developing and improving antiviral therapies. While RNA turnover has long been studied in the context of cellular gene regulation and quality control mechanisms, the interplay between RNA turnover and viral life cycles is only now emerging as a key component of virus-host interactions. For example, Herpes viruses, Poxvirus, Influenza virus and SARS-Coronavirus encode ribonucleases that cleave host mRNA and thereby support virus reproduction. Flaviviruses such as Dengue virus, West Nile virus and Hepatitis C virus encode a non-coding RNA that blocks Xrn1, a major cellular exoribonuclease, as a means to escape from an antiviral activity. The endonuclease RNase L is another component of the mammalian antiviral defense system, highlighting the importance of ribonucleases in the encounter of viruses with their host cells.

This EMBO Workshop will bring together molecular biologists working on basic mechanisms controlling RNA turnover with virologists exploring RNA turnover in the context of virus-host interactions, and propel the scientific exchange in this emerging area of research.

European Molecular Biology Organization – EMBO

Biologie,    Berufliche Laufbahn und Management

The focus of this meeting is to highlight advances in the field of nucleosides, nucleotides, and oligonucleotides. Speakers will discuss chemical biology, synthesis, structure, and therapeutic applications of natural and engineered small molecules and oligomers.

Chemical Biology and Clinical Applications of Nucleosides, Nucleotides and Oligomers

European Molecular Biology Organization – EMBO

Polyamines in Cancer, Medical Genetics, Aging, Pathogens and Plants

For many years, nucleos(t)ide analogues and nucleic acids have served as cornerstones of drug design and development efforts. The Nucleosides, Nucleotides and Oligonucleotides (NNO) Gordon Research Conference is dedicated to understanding the fundamental chemistry, biology, and technologies for the diagnosis and treatment of various diseases using nucleos(t)ides and nucleic acid analogues. In recent years nucleic acids have seen wide use in chemical biology investigations as well as in the clinic as therapeutics and diagnostics. Emerging areas like CRISPR gene editing and siRNA have been developed due to the extensive efforts of many in the NNO field. The 2023 edition will be the 21st NNO GRC and will reflect the evolution of the field and the current explosive growth of NNO based therapeutics, from its original focus on purine and pyrimidine chemistry and biology, to the much broader current scope.

Chemical Biology of Nucleosides and Nucleic Acids Towards Human Therapeutics

Pharmakologie und Arzneimittelentwicklung,    Biochemie und Medizinische Chemie, Toxikologie

Laboratory of Support to Research in Molecular Medicine and Department of Biomedicine, Faculty of Medicine of the University of Porto

The Essential Molecular Biology course covers the fundamental principles and techniques used in experimental research in the area of Molecular Biology.

Essentially practical in nature, it aims at the learning of current genomics and proteomics techniques, as well as the acquisition of skills in laboratory experimentation required for scientific research in Biomedicine.

An exciting way to learn the essential genomics and proteomics techniques used in experimental research in biomedicine: hands-on, practical, intensive.

Tel.: [00351 220 426 779];     Email: mlsoares@med.up.pt

Molecular biology, genomics, proteomics, hands-on, laboratory work, practical

European Molecular Biology Organization – EMBO

In this workshop, EMBO Press editors work with PhD students, Postdocs or junior group leaders on the principles and practicalities of peer review. Topics covered include the key elements of good peer review and the role of peer review in publishing reproducible science. We also discuss ethical considerations such as conflicts of interest and give guidelines to young scientists about how to become good reviewers. The course includes a balanced combination of theory presentation, group work, and interactive discussions to keep the participants engaged.

Biologie,    Berufliche Laufbahn und Management

European Molecular Biology Organization – EMBO

The antibody response and the complement system are major effector arms of the immune system. Next to their beneficial roles in host defense, antibodies and complement are also involved in a plethora of pathological conditions—including autoimmunity, allergy and cancer—and regulate, mainly through their receptors (FcR and CR respectively) cell activation, migration, survival but also metabolism. As the portfolio of antibody—and complement-effector function grow, high-end technological solutions are developed, and novel therapeutic applications are proposed. This EMBO Workshop on Antibody & Complement will be a forum for leaders in the field and new investigators coming from academia, industry and research institutes to discuss where the field is going and what challenges lie ahead. We will focus attention on key advances in both fields with the aim at fostering discussions between antibody experts and complement experts.

European Molecular Biology Organization – EMBO

The successful management of research projects is key to success in science. Understanding what project management is, when it is helpful and how to apply it in research is an important skill for scientists. This course, developed by CJ Fitzsimons—author of "International Project Management - intercultural cooperation in practice" (German language)—introduces key concepts in project management, both for planning and managing work, and for working effectively with people (including with yourself). The course is in English.

Biologie,    Berufliche Laufbahn und Management

European Molecular Biology Organization – EMBO

Banff International Research Station (BIRS) for Mathematical Innovation and Discovery

Cells are the fundamental building blocks of life. Recent advancement in biotechnology has allowed us to peek inside this every cell for better understanding of biology and human disease. Single-cell technology also generates big and complex data and brings about new data science challenges for computational and life scientists. The objective of this workshop is to bring together international leaders in diverse disciplines including mathematical, statistical, computational, biological and medical in a collaborative atmosphere to develop the collaborative capacity that will tackle various underlying data science challenges in single-cell research.

Systembiologie und mathematische Biologie,    Wissenschaftliches Rechnen und Datenwissenschaft

European Molecular Biology Organization – EMBO

Biologie,    Biophysik

Fusion Conferences

The conference will provide the platform for researchers in the recombination and repair fields to present their new unpublished data that sheds novel insights into not only the mechanisms of DSB repair by recombination, but also the consequences of inaccurate repair leading to cancer. It is now clear that many inheritable cancers, including those linked to defects in the BRCA1 or BRCA2 genes, are caused by defects in homologous recombination. Understanding the precise mechanisms of recombinational repair is therefore critical for the development of new drugs that can target these diseases and improve human health.

Biologie,    Genomforschung und Bioinformatik

UC Santa Barbara, Kavli Institute for Theoretical Physics (KITP)

A long-standing question in the neurobiology of learning is that of timescales. The brain can associate events that are separated by seconds, minutes, hours, days, weeks, or longer. Yet, the known biological mechanisms for inducing changes in the synaptic connections between neurons are driven by neural events that are separated by typically no more than a few tens or hundreds of milliseconds. This conference will convene scientists studying the molecular, cellular, and circuit-level mechanisms used by the brain to bridge the multiple timescales across which events play out in the experience of an individual. The goal will be to assemble an up-to-date understanding of the set of biological mechanisms available in the brain to support associative learning across different timescales. The conference's emphasis on biological mechanisms will complement and support the main program’s more computational focus, and encourage an integrated analysis of statistical learning spanning molecular, cellular, circuit, and behavioral-level phenomena.

Neuronale Netze und Künstliche Intelligenz, Maschinelles Lernen,    Neurologie

European Molecular Biology Laboratory | EMBL

As fluorescence lifetime-based readouts become more accessible, this course aims to provide a broad understanding of how the lifetime-based information can be leveraged to solve biological questions. This application-centred course will provide insights into how this additional dimension of fluorescence information can help unveil functional and mechanistic information.

Biologie,    Mikroskopie

European Molecular Biology Organization – EMBO

In this interactive workshop, trainers work with participants to explore the principles and challenges of integrity and reproducibility in research. Research integrity is addressed at multiple stages of the research process, from experimental design to the analysis and sharing of results.  Participants will gain a better understanding of the ‘dos’ and ‘don’ts’ of conducting and sharing scientific research and will realise that research integrity is important and valuable not only for the scientific record, but also for their own work and careers.

Biologie,    Berufliche Laufbahn und Management

Fusion Conferences

Mitochondria act at the interface of numerous processes critical for cellular function and organismal health. Long recognized as the powerhouses of the cell, mitochondria are emerging as hubs for cellular metabolism, redox balance, signalling, gene expression, detoxification, and ion homeostasis. Mitochondrial maintenance is critical for proper development and function of cells and tissues, and mitochondrial dysfunction underlies numerous disease processes ranging from severe childhood mitochondrial disorders, to heart disease, neurodegenerative disorders, cancer, and aging itself. This conference will bring together scientists and clinicians with expertise in a breadth of mitochondrial biology to explore topics at the interface of basic and translational biology. Mitochondrial basic mechanisms of organelle regulation, mitochondrial mechanisms of disease, cutting edge technologies, and interventional strategies will be emphasized in interactive scientific sessions.

Biologie,    Physiologie und Metabolismus des Menschen

European Molecular Biology Organization – EMBO

Recent progress in biology has led to an explosion of factual knowledge about the living world over a huge range of scales in space and time. Yet, many questions about how to make sense of this data remain across the entire diversity of the living world from the smallest bacterium to the ecosystems of the Serengeti. This meeting aims to bring together a diverse collection of researchers interested in finding ways to parlay this ever-increasing factual knowledge into a corresponding array of conceptual knowledge. The goal of this symposium is to assemble an interdisciplinary community and to provide a platform to discuss perspectives on the role of theory in biology, and importantly also vice versa, the impact that biology can have on theory.

Biologie,    Systembiologie und mathematische Biologie

European Molecular Biology Organization – EMBO

Biologie,    Systembiologie und mathematische Biologie

European Molecular Biology Organization – EMBO

This GRC will be held in conjunction with the "Wnt Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information. Conference Program The session topics for this conference are being developed by the conference chairs. Please check back regularly for updates to this information. Contributors Gordon Research Conferences National Institutes of Health - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ImmunoPrecise Antibodies STEMCELL Technologies Inc. PeproTech Inc. Pfizer, Inc. Bio-Techne JW Pharmaceutical Corporation Leap Therapeutics Conference Links Conference History Wnt Signaling (GRS) Contribute Financially to This Conference Conference Fees Similar Conferences Poster Information Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Cell Biology and Signalling

Isaac Newton Institute for Mathematical Sciences (INI)

The workshop will explore the use of modern mathematical techniques for the study of problems at the interface between biology and mechanics. It includes the use of machine learning, Baysean methods, and uncertainty quantification for a wide range of problems in biology, physiology, and medicine (biophysics of the cell, brain, the heart, morphogenesis,…)

Biophysik,    Biologie

European Molecular Biology Organization – EMBO

BPS - The Biophysical Society

A vast number of biologically important enzymes, transporters, and other molecules require the participation or transport of protons. Because the proton is unique in many respects, its properties and reactions are often quite distinct from those of other ions. Our goal is to include a truly international spectrum of speakers and attendees. The invited speakers include chemists, structural biologists, and physiologists whose expertise encompasses a wide range of topics that are all related to the proton. We hope to encourage new understandings on levels from basic science to biomedical applications.

European Molecular Biology Organization – EMBO

Any adequate theory of evolutionary change must cover both the sources and the consequences of phenotypic variation. On the one hand, we must understand the various processes—genetic, metabolic, physiological, developmental, and behavioral—that generate variation. On the other hand, we must understand the sorting processes that lead to the differential survival of different variants. The latter aspect is covered by traditional evolutionary genetics, with its well-developed set of concepts and models. In contrast, there seems to be no overarching theory or unifying framework able to explain the enormous diversity of processes generating variation. These processes are not only dauntingly complex, but also occur at many different levels of organization—from the molecular to the cellular, tissue, organ, organismic, and even supra-organismic levels (ecological or social). We could conclude from this that no theory of the sources of variation is possible, or we could call for a novel, empirically grounded, organismic systems biology that integrates philosophical, mathematical, and experimental approaches to tackle the issue. We will look at this project from a broad theoretical vantage point to assess the future of evolutionary and developmental systems biology.

Biologie,    Systembiologie und mathematische Biologie

European Molecular Biology Organization – EMBO

Following the elucidation of the structure of DNA, it was clear that the iconic double helical structure of DNA would impact and impede the fundamental genomic transactions required for cellular life. Even after 70 years of research, novel roles for DNA topology and topoisomerase action in transcriptional control, chromosome structure, anti-viral responses and genome stability are still being uncovered. We are also still deciphering how many chemotherapeutics target topoisomerases and DNA topology impacted processes. The EMBO workshops on DNA topology and topoisomerases bring together scientists who have only recently discovered the importance of DNA topology in their specialties with long standing researchers in the field. This generates a vibrant interdisciplinary meeting, which highlights and disseminates work involving diverse and rapidly evolving approaches. This workshop highlights studies using techniques as varied as single molecule physics and structural biology, pan-genomic analysis of chromosome structure and chromatin composition and live cell single particle tracking to uncover new findings on the nature of DNA topological transactions and how they impact cellular processes.

Isaac Newton Institute for Mathematical Sciences (INI)

This workshop brings together experimental and theoretical researchers who work on cell mechanics, on three different scales. At the microscopic scale, the cytoskeletal active network shapes the cell and generates active forces. At the mesoscale, the collective motion and mechanics of cells gives rises to tissues such as epithelial cell sheets which have become a premier biophysical model system. In the full biological context of cell and developmental mechanics, such as in model tissue organoids, shapes and function arise through the interplay of this active mechanics with morphogens and signalling. Our workshop will explore these three scales of size and complexity, with a view towards bridging the gaps between communities and developing a true multiscale understanding.

Biophysik,    Biologie

European Molecular Biology Organization – EMBO

Biologie,    Mikroskopie

European Molecular Biology Organization – EMBO

Biologie,    Mikroskopie

European Molecular Biology Laboratory | EMBL

Mechanisms that shape cellular proteomes are critical for life. This conference focuses on the process of protein synthesis, from the molecular and structural understanding of the translational machinery to its regulation, its implications in cell and organismal biology, and its alteration in disease. The regulation of mRNA translation is critical to maintain cell homeostasis and mediates cellular responses to environmental, physiological, and pathological cues. Given the central importance of protein synthesis, it is unsurprising that dysregulation or defects in mRNA translation are widely linked to disease, including cancer, neurological or metabolic disorders, and viral infection. In recent years, technical advances have challenged hitherto established dogmas, uncovered new quality control mechanisms, expanded the breath of translation regulators, enhanced our understanding of the dynamics of translation in living cells, and revealed unexpected interconnections with other cellular processes such as metabolism. Advances on these aspects of mRNA translation will be featured, as well as new insights into translation regulation in physiology and disease.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Biologie,    Mikroskopie

European Molecular Biology Organization – EMBO

This EMBO Workshop strives to connect disciplines from different fast-moving fields linked to endocytosis, which require a common forum to discuss the latest developments and future directions in an integrated fashion. The final goal is to uncover novel molecular and cellular networks involving endocytosis by providing concrete examples of how collaborations between researchers from different disciplines are currently leading to fundamental discoveries.

Biologie,    Biophysik

European Molecular Biology Organization – EMBO

Postponed from 12 - 17 September 2021

The Beilstein Enzymology Symposia series provide not only a platform for the presentation of the latest findings in mechanistic and systemic enzymology but also for discussing standards for measuring and publication of experimental data such as proposed by the STRENDA Commission.

European Molecular Biology Organization – EMBO

Oxford Global Conferences

Join oligo leaders, experts and distinguished scientists in Europe, delivering breakthrough research, technologies & connecting global pharma, biotech and academia for high-level discussions on the latest innovations within the oligonucleotides chemistry & therapeutics development.

Tel.: [+44 1865 248455];     Email: h.liddiard@oxfordglobal.co.uk

Oligonucleotides chemistry, biotechnology, oncology, Genetic disorders, Rare diseases, Infectious diseases, Cardiovascular diseases, Kidney diseases

Onkologie,    Biotechnologie

Oxford Global Conferences

Learn from key opinion leaders working to deliver RNA therapies for several therapeutic areas including infectious disease and cardiovascular disease. Across two in-depth sessions the latest improvements pushing the industry forward will be addressed: from RNA formulation strategies, design and development through to antisense and oligo-mediated RNA delivery and improvements in extrahepatic delivery approaches.

Tel.: [+44 1865 248455];     Email: h.liddiard@oxfordglobal.co.uk

RNA, Nanoparticles, Immunology, mMRA, Oligonucleotides

European Molecular Biology Laboratory | EMBL

This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies.

Biotechnologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

This EMBO Workshop will bring together an interdisciplinary and diverse group of scientists discussing recent developments and cutting-edge advances in LD research. The meeting is going to provide a unique platform for exchange between basic and clinical researchers across all career levels with ample opportunity for networking and career development.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Genome evolution represents the basis of species adaptation to changing environments and habitats. Recent breakthroughs in sequencing technologies resulted in the acquisition of complete genome information for an increasing number of animal species, propelling the field of evolutionary genomics into a new era of discovery. Yet, our limited capacity to interpret genome variation hinders our understanding on how phenotypical changes drive adaptation. This urges the development of novel strategies to reconcile genomic sequence and function, for which a proper integration of cell-specific gene programs, non-coding regulation and 3D chromatin organization becomes essential. Further, establishing causal relationships between genome mutations and phenotypes still remains a major challenge in the field. Within this context, novel synthetic biology approaches are emerging as a means to understand developmental processes in the context of evolution. The aim of this EMBO workshop is to bring together international scientists with distinct, but complementary expertises on interpreting genome variation, on mechanisms of gene regulation and on in vivo synthetic biology approaches. This allows a comprehensive overview that goes from fundamental principles encoded in genomes to their ultimate biological significance on the formation of living, evolving organisms.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The ReSOLUTE-IMI Consortium

The RESOLUTE and REsolution consortia of the Innovative Medicines Initiative of the European Union have been empowering over the last years the scientific community with novel research tools and datasets for transporters of the Solute Carrier (SLC) supergroup. In 2023, both projects are coming to an end, and we would like to finish with a big celebratory and future-looking conference: “Unlocking Transporters for Drug Discovery”. At the event expect to see presented the results and lessons learned by the RESOLUTE and REsolution consortia over the last five years. Furthermore, top international scientists interested in metabolism and its regulation, drug discovery, the function and structure of membrane proteins will be speaking.

RESOLUTE Communications Manager;     Email: contact@re-solute.eu

transporters, solute carriers, SLC, genomics, metabolomics, proteomics, systems biology, data integration, drug discovery, medicine, variants, mutants, structural biology, resources, bio-tools, cell lines, plasmids

Systembiologie und mathematische Biologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

For decades, studies in cell biology have focused on discovering the functions and dynamics of individual organelles. However, organelles do not exist only as single units, but also as part of entities formed through contacts between two or more distinct organelles. In fact, the recent years of studies on inter-organelle contacts have revealed that complex cellular functions, biochemical processes and signaling pathways are governed at the sites where heterotypic organelles come into contact with each other. This paradigm shift has spurred a new gold rush of research in cell biology that is transforming our understanding of cell physiology, signaling and metabolism in health and disease. This EMBO Workshop on inter-organelle contacts biology, now at its 3rd edition, aims at bringing together the community of scientists in this field to share their work, experience, expertise, and vision.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The successful management of research projects is key to success in science. Understanding what project management is, when it is helpful and how to apply it in research is an important skill for scientists. This course, developed by CJ Fitzsimons—author of "International Project Management - intercultural cooperation in practice" (German language)—introduces key concepts in project management, both for planning and managing work, and for working effectively with people (including with yourself). The course is in English.

Biologie,    Berufliche Laufbahn und Management

The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease.

In situ structural biology, Super-resolved imaging, Probes & biosensors, Organismal imaging, Correlative imaging, Image analysis, Discoveries by bioimaging

Biologie,    Mikroskopie

Fusion Conferences

The germline provides an eternal cellular link between generations and is the source of genetic diversity and evolution of animal populations. In addition, perturbations in the epigenome or genome of a parental germline that arise during development could be underlying causes of many disease states in offspring. In males, sperm are the conduit for transmission of genetic and epigenetic information to the next generation and are formed by the complex process of spermatogenesis, which involves undifferentiated stem cell, differentiating, meiotic, and morphogenesis phases. This workshop will explore recent advances in understanding the biology of these different phases in a variety of animal models as well as how epigenetic and genetic abnormalities may underlie transmission of diseases and fertility disorder in humans. Invited talks and poster sessions that focus on cutting edge findings along with vibrant discussions and debates about controversies in the field will provide a rich intellectual atmosphere that is sure to have an important impact on how the biology of spermatogenesis is investigated for years to come.

Biologie,    Stammzellforschung und -therapie

Fusion Conferences

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Biologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Over the past decades it became evident that a RNA transcripts specific amount and localisation are important in order to understand the biological function of its (non-) coding gene. Whereby state-of-the-art in situ hybridisation (ISH) technologies are key to visualise these RNAs in a given tissue or cell. This course aims to highlight three powerful RNA visualisation techniques in histological tissue samples. During this course, the participants will learn to validate the cellular localisation of candidate genes from transcriptome studies through conventional ISH and, the more recent cutting-edge, smFISH (Single Molecule Fluorescent ISH) and HCR-ISH (Hybridization Chain Reaction), based RNA ISH hybridisation methods. Additionally, the course will also cover essential tissue embedding protocols that are adapted for use in visually interrogating RNA transcripts in mammalian tissues.

European Molecular Biology Laboratory | EMBL

This course consists of two parts: virtual and onsite. The virtual course takes place 6 – 10 November 2023 and the onsite part takes place 27 November – 1 December 2023.

The virtual course will cover the basics of SAXS/SANS, instrumentation, data collection, modelling techniques and complementary use with other methods. The students are encouraged to sign-up for a self-paced practical tutorial that covers basic and advanced SAXS data processing steps (including quizzes to keep track of successful participation). In addition, students are encouraged to apply to the ‘add on module’ which includes an on-site visit (5 days) in Hamburg to participate either in track 1: X-ray beamline operation or track 2: sample optimisation for SAXS. Students not travelling to Hamburg can sign up for small discussion groups to discuss their SAXS data in more detail.

Biologie,    Biochemie und Medizinische Chemie, Toxikologie

Society for Muscle Biology

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Laboratory | EMBL

Flow Cytometry is one of the most powerful single cell analysis methods used throughout the life sciences and medicine. By utilising Flow Cytometry we can identify and quantify specific cell populations from heterogeneous samples, analyse the cell cycle or proliferation state or simply detect the expression of fluorescent reporters. In line with the suggestions from our course in 2019, we will significantly enhance the number of analysis sessions together with our partners from FlowJo. We will cover the theory of Flow Cytometry and corroborate this information intensively with the practical issues of the most frequent assays as part of our practical course curriculum.

Isaac Newton Institute for Mathematical Sciences (INI)

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Laboratory | EMBL

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Biologie,    Systembiologie und mathematische Biologie

European Molecular Biology Organization – EMBO

This inaugural EMBO | EMBL Symposium aims to showcase the future of plant biology. Going beyond the limited number of model plants that plant biologists have historically focused on (e.g. Arabidopsis, corn, rice), it is nowadays possible to use comparative approaches to uncover the mechanistic basis and the evolutionary drive for the enormous phenotypic variation among the 400,000 species of plants on Earth.

Max Planck Institute for the Physics of Complex Systems (mpi-pks)