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Biophysical Society

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The ReSOLUTE-IMI Consortium

The RESOLUTE and REsolution consortia of the Innovative Medicines Initiative of the European Union have been empowering over the last years the scientific community with novel research tools and datasets for transporters of the Solute Carrier (SLC) supergroup. In 2023, both projects are coming to an end, and we would like to finish with a big celebratory and future-looking conference: “Unlocking Transporters for Drug Discovery”. At the event expect to see presented the results and lessons learned by the RESOLUTE and REsolution consortia over the last five years. Furthermore, top international scientists interested in metabolism and its regulation, drug discovery, the function and structure of membrane proteins will be speaking.

RESOLUTE Communications Manager;     Email: contact@re-solute.eu

transporters, solute carriers, SLC, genomics, metabolomics, proteomics, systems biology, data integration, drug discovery, medicine, variants, mutants, structural biology, resources, bio-tools, cell lines, plasmids

Systembiologie und mathematische Biologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

For decades, studies in cell biology have focused on discovering the functions and dynamics of individual organelles. However, organelles do not exist only as single units, but also as part of entities formed through contacts between two or more distinct organelles. In fact, the recent years of studies on inter-organelle contacts have revealed that complex cellular functions, biochemical processes and signaling pathways are governed at the sites where heterotypic organelles come into contact with each other. This paradigm shift has spurred a new gold rush of research in cell biology that is transforming our understanding of cell physiology, signaling and metabolism in health and disease. This EMBO Workshop on inter-organelle contacts biology, now at its 3rd edition, aims at bringing together the community of scientists in this field to share their work, experience, expertise, and vision.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The successful management of research projects is key to success in science. Understanding what project management is, when it is helpful and how to apply it in research is an important skill for scientists. This course, developed by CJ Fitzsimons—author of "International Project Management - intercultural cooperation in practice" (German language)—introduces key concepts in project management, both for planning and managing work, and for working effectively with people (including with yourself). The course is in English.

Biologie,    Berufliche Laufbahn und Management

The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease.

In situ structural biology, Super-resolved imaging, Probes & biosensors, Organismal imaging, Correlative imaging, Image analysis, Discoveries by bioimaging

Biologie,    Mikroskopie

Fusion Conferences

The germline provides an eternal cellular link between generations and is the source of genetic diversity and evolution of animal populations. In addition, perturbations in the epigenome or genome of a parental germline that arise during development could be underlying causes of many disease states in offspring. In males, sperm are the conduit for transmission of genetic and epigenetic information to the next generation and are formed by the complex process of spermatogenesis, which involves undifferentiated stem cell, differentiating, meiotic, and morphogenesis phases. This workshop will explore recent advances in understanding the biology of these different phases in a variety of animal models as well as how epigenetic and genetic abnormalities may underlie transmission of diseases and fertility disorder in humans. Invited talks and poster sessions that focus on cutting edge findings along with vibrant discussions and debates about controversies in the field will provide a rich intellectual atmosphere that is sure to have an important impact on how the biology of spermatogenesis is investigated for years to come.

Biologie,    Stammzellforschung und -therapie

Fusion Conferences

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Biologie,    Genomforschung und Bioinformatik

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Over the past decades it became evident that a RNA transcripts specific amount and localisation are important in order to understand the biological function of its (non-) coding gene. Whereby state-of-the-art in situ hybridisation (ISH) technologies are key to visualise these RNAs in a given tissue or cell. This course aims to highlight three powerful RNA visualisation techniques in histological tissue samples. During this course, the participants will learn to validate the cellular localisation of candidate genes from transcriptome studies through conventional ISH and, the more recent cutting-edge, smFISH (Single Molecule Fluorescent ISH) and HCR-ISH (Hybridization Chain Reaction), based RNA ISH hybridisation methods. Additionally, the course will also cover essential tissue embedding protocols that are adapted for use in visually interrogating RNA transcripts in mammalian tissues.

European Molecular Biology Laboratory | EMBL

This course consists of two parts: virtual and onsite. The virtual course takes place 6 – 10 November 2023 and the onsite part takes place 27 November – 1 December 2023.

The virtual course will cover the basics of SAXS/SANS, instrumentation, data collection, modelling techniques and complementary use with other methods. The students are encouraged to sign-up for a self-paced practical tutorial that covers basic and advanced SAXS data processing steps (including quizzes to keep track of successful participation). In addition, students are encouraged to apply to the ‘add on module’ which includes an on-site visit (5 days) in Hamburg to participate either in track 1: X-ray beamline operation or track 2: sample optimisation for SAXS. Students not travelling to Hamburg can sign up for small discussion groups to discuss their SAXS data in more detail.

Biologie,    Biochemie und Medizinische Chemie, Toxikologie

Society for Muscle Biology

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Laboratory | EMBL

Flow Cytometry is one of the most powerful single cell analysis methods used throughout the life sciences and medicine. By utilising Flow Cytometry we can identify and quantify specific cell populations from heterogeneous samples, analyse the cell cycle or proliferation state or simply detect the expression of fluorescent reporters. In line with the suggestions from our course in 2019, we will significantly enhance the number of analysis sessions together with our partners from FlowJo. We will cover the theory of Flow Cytometry and corroborate this information intensively with the practical issues of the most frequent assays as part of our practical course curriculum.

Isaac Newton Institute for Mathematical Sciences (INI)

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Laboratory | EMBL

European Molecular Biology Organization – EMBO

Uventia Global

The safety, quality and clinical results of drug substances and drug products may be disrupted by the formation of nitrosamines along with other mutagenic impurities. The comprehensive development and production of innovative medicines now inevitably involves estimating impurity profiles as well as managing and monitoring them. To meet the demands of ever-increasing regulatory standards and avoid expensive recalls, proactive detection of genotoxic contaminants should be adopted at every stage of pharmaceutical development. We plan an online meeting with subject-matter experts to evaluate multiple perspectives on how to handle the concerns of mutagenic impurities. We will cover regulatory-compliant drug impurity profiling practices; helpful hints for adhering to recent ICH M7 and Q3D updates; nitrosamine impurity identification and quantification; risk evaluation of genotoxic impurities; analytical challenges and genotoxicity prediction; establishment of acceptance criteria; and the most recent developments in the analysis of elemental impurities. Save a seat at our webinar to find out about most effective methods for genotoxic and other mutagenic impurity management.

Email: yuliia.terletska@uventia.com

Genotoxic, Impurities, GTIs, Genotoxins, Genotoxicity, Mutagenicity, Genetic, Toxicology, Chemical Toxicology, Analytical Chemistry

European Molecular Biology Organization – EMBO

Biologie,    Systembiologie und mathematische Biologie

Department of Experimental Biology, Faculty of Medicine of the University of Porto

The Essential Molecular Biology course covers the fundamental principles and techniques used in experimental research in the area of Molecular Biology. Essentially practical in nature, it aims at the learning of current genomics and proteomics techniques, as well as the acquisition of skills in laboratory experimentation required for scientific research in Biomedicine. An exciting way to learn the essential genomics and proteomics techniques used in experimental research in biomedicine: hands-on, practical, intensive.

Tel.: [+ 351 220426779];     Email: laimm@med.up.pt

Molecular biology, genomics, proteomics, hands-on, laboratory work, practical

Fusion Conferences

The research field of interorganelle contacts is one of the most rapidly growing areas of modern cell biology. It is becoming clear that many, if not all, organelles form membrane contact sites (MCS) with other components of the cell. The term ‘MCS’ broadly describes a physical interaction between two organelles, occurring at specialized subdomains of the given organelle and involved in multiple facets of the biology of the two organelles that are juxtaposed. MCS discovery forced cell biologists to reconsider the way organelles are studied, introducing the concept that heterotypic organelle interaction allows functions that individual organelles would otherwise be unable to perform and forcing them to think in terms of compartmentalized metabolism and signaling.

Fusion Conferences

Neural development continues throughout life in the mammalian brain. This conference will bring together leaders from diverse fields, such as embryonic cortical development, adult neurogenesis, patient-derived stem cell-based 2D and 3B brain organoid disease modelling, direct reprograming and transplantation to discuss recent advances and remaining gaps in the understanding of the cellular and molecular mechanisms regulating neural stem cell activity, neural fate specification and functional significance of circuitries modified by the addition of new neurons in health and diseases.

Neurologie,    Stammzellforschung und -therapie

Fusion Conferences

The conference program covers how RNA and RNA-dependent machineries govern chromatin landscape, gene expression, and genome architecture during development, homeostasis, and in response to cellular stress. This conference prioritises high-throughput and systems biology approaches that convey new mechanistic insights into genome regulation and will also highlight emerging methods/technology that will propel the field forward in the coming years.

Fusion Conferences

In recent years, significant advancements have revolutionized the ability to study distinct biological features at the level of individual cells, resulting in profound implications for biology and medicine. These breakthroughs encompass novel microfluidic techniques, molecular advancements in next-generation sequencing, spatial technologies, and the development of computational platforms capable of analyzing large-scale sequencing data. As a result, we can now profile the genome (through DNA sequencing), transcriptome (using RNA sequencing), and epigenome (via ATAC sequencing and DNA methylation sequencing) at the resolution of single cells. This wealth of information has provided unprecedented insights into the biological composition of various cell types, tissues, and even whole organisms.

Fusion Conferences

The 6th DNA Repair/Replication Structures & Cancer conference on 14-18 February 2024 will focus on molecular structural and mechanistic insights into dynamic complexes acting in DNA repair, replication, and inflammation and their intersections relevant to advanced cancer therapies. This fundamental information will be pivotal for pioneering research on DNA damage responses as well as for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions, collaborations, and insights. In this conference and this area of science basic research is empowering medical advances and clinical data are unveiling basic relationships in ways that are completely changing how research and translation is being done.

Onkologie,    Genomforschung und Bioinformatik

Banff International Research Station (BIRS) for Mathematical Innovation and Discovery

Kurse und Veranstaltungen für Studenten der Mathematik,    Graphentheorie und Kombinatorik

The event, which will take place on 8-9 April at the University of Leeds, brings people together from across the globe to discover, explore and inspire ideas whilst showcasing the latest innovations making waves in molecular biology. This year’s theme is ‘Illuminating Life’, which will shine a light on the hidden world of macromolecules.

Co-hosted by Asia Pacific Foundation for Infectious Diseases, Korean Society for Antimicrobial Therapy

ISAAR 2024 & Annual Conference of KSAT aims to provide comprehensive information on infectious diseases and multiple opportunities for face-to-face networking. Our event will focus on important topics such as antibiotic resistance, clinical implications, diagnostic techniques, development of new antibiotics, and treatment guidelines. We will also discuss the silent pandemic that threatens global public health, as well as timely topics such as vaccine development, antimicrobial resistance, and the microbiome, recent advances in the diagnosis and treatment of infections, changing infection control trends and strategies, and emerging infectious diseases that may represent the next pandemic after COVID-19. With over 1,500 world-class infectious disease experts from over 50 countries, with 50 invited speakers from around the world, it provides an ideal platform for networking and scientific exchange among researchers.

ISAAR 2024 & Annual Conference of KSAT Secretariat;     Tel.: [82-2-3413-0327];     Email: isaar@apfid.org

Antimicrobial stewardship, Difficult-to-treat Pseudomonas aeruginsa & Carbapenem-resistant Acinetobacter, One health and antimicrobial resistance, Infection prevention and control, Microbiome, Viruses (excl. COVID-19), Vaccine, Gra positive bacteria, COVID-19 (focusing on post-COVID sequelae and vaccine), Diagnostics, How to mitigate the risk using the environmental management, Updates in infection prevention practices & research, Antifungal Resistance; current trends and strategies to overcome

Infektiologie,    Epidemiologie

European Molecular Biology Organization – EMBO

This inaugural EMBO | EMBL Symposium aims to showcase the future of plant biology. Going beyond the limited number of model plants that plant biologists have historically focused on (e.g. Arabidopsis, corn, rice), it is nowadays possible to use comparative approaches to uncover the mechanistic basis and the evolutionary drive for the enormous phenotypic variation among the 400,000 species of plants on Earth.

Max Planck Institute for the Physics of Complex Systems (mpi-pks)

Department of Experimental Biology, Faculty of Medicine of the University of Porto

The Essential Molecular Biology course covers the fundamental principles and techniques used in experimental research in the area of Molecular Biology. Essentially practical in nature, it aims at the learning of current genomics and proteomics techniques, as well as the acquisition of skills in laboratory experimentation required for scientific research in Biomedicine. An exciting way to learn the essential genomics and proteomics techniques used in experimental research in biomedicine: hands-on, practical, intensive.

Tel.: [+351 220426779];     Email: laimm@med.up.pt

Molecular biology, genomics, proteomics, hands-on, laboratory work, practical

Focus in precision biochemistry and precision medicine

The Company of Biologists Ltd

Evolutionary cell biology represents the integration of evolutionary theory, phylogenetics and experimental evolution with comparative cell biology, aiming ultimately to understand how and why cells evolved to be the way they are. This meeting aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology, traversing both spatial scales – from subcellular cytoskeletal dynamics to symbiotic interactions – and evolutionary time. At a time when advances in phylogenetics, imaging, biochemical profiling, and genetic engineering have enabled comparative biology and experiments in non-model systems at an unprecedented scale, we hope to inspire the next generation of evolutionary cell biologists to tackle some of the biggest questions in modern cell biology.

Fusion Conferences

We have reached a fascinating point in our research on the ubiquitin system’s function, physiology and roles in disease. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable degradation of proteins in the cytosol by the proteasome. It was much later that it was discovered that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives a multitude of signalling pathways the required plasticity to initiate but also to limit their signalling output in an exquisitely controlled manner. Whereas certain signalling-related functions employ ubiquitin’s proteasome-targeting function, e.g. the activation of NF-kB following degradation of I-kB, most signalling-related functions of the ubiquitin system are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.

MIAPbP - Munich Institute for Astro-, Particle and BioPhysics an institute of the Excellence Cluster ORIGINS

Likely pathways from the inanimate to the animate world involve a transition that can be thought of as the emergence of information in molecular systems. Before this transition, heteropolymers already exist, but the sequence information of a polymer does not persist beyond the lifetime of the polymer. During the transition, information becomes a separate dynamical entity, which lives and changes over longer timescales than its carrier molecules. This transition does not necessarily require the existence of a full-fledged replication machinery, such as polymerase enzymes that copy informational polymers. Instead, the interplay of simpler reactions can create strong correlations in pools of informational polymers, which can also decouple the timescales of the informational dynamics from those of the polymer dynamics. This interplay is only beginning to be studied, experimentally as well as computationally and theoretically, such that many conceptual and methodological questions are currently open. The central aim of this workshop is to bring together scientists with different backgrounds, in order to attack these questions together.

Kurse und Veranstaltungen für Physikstudenten,    Wissenschaftliche Philosophie

Fusion Conferences

We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.

Fusion Conferences

Defects in DNA damage repair and checkpoint control are underlying mechanisms driving tumorigenesis, since they allow for the accumulation of genetic alternations. Indeed, defects associated with these pathways are the underlying cause of several human cancer-prone syndromes. On the other hand, defects in DNA repair and checkpoint control create vulnerabilities in cancer cells that can be targeted by DNA damaging agents and inhibitors that disrupt checkpoint pathways. More recently, defective DNA repair and checkpoint regulation have been shown to influence R-loop formation, replication fork stability, and innate immunity. These new findings not only reveal additional mechanisms contributing to tumorigenesis, but also provide new targets for cancer therapy. This conference will focus on exploring these vulnerabilities, taking advantage of the synthetic lethality concept, and targeting specific DNA repair and checkpoint pathways for cancer therapy, either alone or in combination with chemotherapy, radiation therapy, targeted therapy, and immunotherapy. This conference will bring together basic, translational and clinical investigators to discuss current and future directions, opportunities and obstacles to the development of these anti-cancer modalities and how to best translate these concepts to clinical practice.

Fusion Conferences

Chromatin is the template of life, the carrier of genetic information and the core regulator of fundamental processes such as gene expression and stem cell fate determination. Chromatin dysfunction on the other hand can trigger various diseases, including cancer. Although chromatin structure and function and the mechanisms of disease and their diagnostic and therapeutic approaches are the subject of many meetings, conferences bringing them together are less frequent. The boundaries among these various disciplines are disappearing and meeting on "Epigenetics: from mechanisms to disease" will focus on the discussion of the role of chromatin architecture, epigenetics, stem and single cell biology in cancer and other diseases. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation, exploiting the power of genome engineering technologies, single-cell approaches, cutting edge epigenomics and imaging approaches and novel cell systems such as organoids.

Focuses on the convergence in these rapidly evolving areas, spanning from basic biology to clinical diagnostics and therapeutic applications.

Addresses all aspects of development and applications of biomedical optical technologies for research and clinical applications.

Biophysik,    Optik und Laser

Optoelektronik und Anzeigetechnik,    Biologie