European Molecular Biology Organization – EMBO
Defining the end of transcription units across eukaryotic genomes is critical to understanding how individual genes are regulated. RNA 3' end processing triggers release of transcripts from their chromatin template, leading to production of messenger RNA as well as triggering degradation of excess transcripts. To fully understand this process it is important to consider how RNA 3' end formation is coordinated with gene transcription and other RNA processing mechanisms. Furthermore the mindshift in considering RNA 3’ ends in the context of the whole genome and its transcriptome requires extensive computational biology/bioinformatics to fully appreciate the genome wide biological roles of this process. This EMBO Workshop will bring together many of the top scientists in this field who employ a combination of molecular biology approaches that also harness recently developed bioinformatics, proteomics and computational based cryoEM. Surprisingly even though aspects of this subject area have been under investigation for decades, only now do we appreciate how critical this process is to gene expression in a genomic context. In particular recent studies show that cellular stress through viral infection or cancer induction both cause a breakdown in RNA 3' end regulation. All of these and more topics will be covered in our forthcoming, intense and in person EMBO workshop on RNA 3’ ends at Brasenose College Oxford this September, 2022.
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