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Oxford Global Conferences

Gene Therapy Development & Manufacturing 2023 delivers in-depth discussion on optimised process strategies and technologies for the successful technical development and manufacture of advanced gene therapy products.

Phone: [+44 1865 248455];     Email: h.liddiard@oxfordglobal.co.uk

Gene therapy, biology, vector development, gene editing, personalised medicine

Cambridge Healthtech Institute

The ubiquitin-proteasome, lysosome and autophagy systems are all well-controlled, selective degradation pathways that are key cellular regulators in cancer, CNS, and other diseases. A new generation of hetero bi-functional chimeras and small molecule monovalent degraders are being developed to hijack these systems for targeted protein degradation or stabilization. These molecules that include Proteolysis-targeting chimeras (PROTACs) and molecular glues are being used to seek out previously “undruggable” targets for therapeutic intervention. However, challenges do exist in terms of specificity, stability, biodistribution and penetration of these degrader molecules. This conference on Next-Generation Degraders & Glues brings together experts in the field to discuss these new therapeutic modalities, as well as issues underlying the use of targeted degradation as a new therapeutic approach.

Marketing Manager;     Email: aorktiese@healthtech.com

PROTACs, Molecular Glues, Protein Degradation

Isaac Newton Institute for Mathematical Sciences (INI)

The workshop will explore the use of modern mathematical techniques for the study of problems at the interface between biology and mechanics. It includes the use of machine learning, Baysean methods, and uncertainty quantification for a wide range of problems in biology, physiology, and medicine (biophysics of the cell, brain, the heart, morphogenesis,…)

Biophysics, Medical Physics,    Biology

Isaac Newton Institute for Mathematical Sciences (INI)

This workshop brings together experimental and theoretical researchers who work on cell mechanics, on three different scales. At the microscopic scale, the cytoskeletal active network shapes the cell and generates active forces. At the mesoscale, the collective motion and mechanics of cells gives rises to tissues such as epithelial cell sheets which have become a premier biophysical model system. In the full biological context of cell and developmental mechanics, such as in model tissue organoids, shapes and function arise through the interplay of this active mechanics with morphogens and signalling. Our workshop will explore these three scales of size and complexity, with a view towards bridging the gaps between communities and developing a true multiscale understanding.

Biophysics, Medical Physics,    Biology

European Molecular Biology Organization – EMBO

Biology,    Microscopy

European Molecular Biology Organization – EMBO

Biology,    Microscopy

Isaac Newton Institute for Mathematical Sciences (INI)