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European Molecular Biology Organization – EMBO

Biologie des systèmes,    Cancérologie

Fusion Conferences

The germline provides an eternal cellular link between generations and is the source of genetic diversity and evolution of animal populations. In addition, perturbations in the epigenome or genome of a parental germline that arise during development could be underlying causes of many disease states in offspring. In males, sperm are the conduit for transmission of genetic and epigenetic information to the next generation and are formed by the complex process of spermatogenesis, which involves undifferentiated stem cell, differentiating, meiotic, and morphogenesis phases. This workshop will explore recent advances in understanding the biology of these different phases in a variety of animal models as well as how epigenetic and genetic abnormalities may underlie transmission of diseases and fertility disorder in humans. Invited talks and poster sessions that focus on cutting edge findings along with vibrant discussions and debates about controversies in the field will provide a rich intellectual atmosphere that is sure to have an important impact on how the biology of spermatogenesis is investigated for years to come.

Biologie moléculaire,    Cellules souches

Fusion Conferences

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Mechanisms of aging are conserved in evolution, and discoveries made in animals are informing our understanding of human aging. This raises the intriguing possibility of performing preventative medicine against chronic and age-related diseases, by targeting their main risk factor, namely aging. Important current challenges in the field are (1) to understand the downstream pathways by which longevity interventions can combat age-related loss of function and pathology, (2) to evaluate the impact of regenerative interventions and cellular reprogramming on age-related diseases, and (3) to translate the findings into the extension of human health span.

Mitochondrial quality control and aging; Ultra long lives and immortality; Autophagy and proteostasis; Regenerative interventions and cellular reprogramming; Human ageing: biomarkers and cell senescence; Microbiome and aging

Physiologie et métabolisme,    Gériatrie

Fusion Conferences

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Biologie moléculaire,    Génomique et bio-informatique