European Molecular Biology Organization – EMBO
RNA and protein degradation play critical roles during dynamic proteome remodeling in response to developmental and environmental cues. Although RNA and protein degradation pathways have often been investigated in isolation, there is a growing interest in understanding how RNA decay and protein degradation systems interact and cooperate to shape both the RNA and protein landscape within cells and tissues. For example, an explosion of recent research has demonstrated that RNA decay and protein degradation cooperate when ribosome progression is halted to facilitate removal of potentially toxic mRNA and/or protein species. Further, regulating the abundance of either RNA or cognate RNA binding proteins can alter the behavior of highly dynamic macromolecular assembles that can form liquid-like condensates and have been linked to various human pathologies. The purpose of this EMBO Workshop is to bring together experts in the RNA decay and protein degradation fields to report on our current understanding of RNA and protein degradation pathway intersections, discover common principles, and share technical expertise on best practices to interrogate RNA or protein turnover.
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