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European Molecular Biology Organization – EMBO

Postponed from 19 – 24 September 2021

Biology,    Human Physiology and Metabolism

European Molecular Biology Organization – EMBO

RNA and protein degradation play critical roles during dynamic proteome remodeling in response to developmental and environmental cues. Although RNA and protein degradation pathways have often been investigated in isolation, there is a growing interest in understanding how RNA decay and protein degradation systems interact and cooperate to shape both the RNA and protein landscape within cells and tissues. For example, an explosion of recent research has demonstrated that RNA decay and protein degradation cooperate when ribosome progression is halted to facilitate removal of potentially toxic mRNA and/or protein species. Further, regulating the abundance of either RNA or cognate RNA binding proteins can alter the behavior of highly dynamic macromolecular assembles that can form liquid-like condensates and have been linked to various human pathologies. The purpose of this EMBO Workshop is to bring together experts in the RNA decay and protein degradation fields to report on our current understanding of RNA and protein degradation pathway intersections, discover common principles, and share technical expertise on best practices to interrogate RNA or protein turnover.

Fusion Conferences

The germline provides an eternal cellular link between generations and is the source of genetic diversity and evolution of animal populations. In addition, perturbations in the epigenome or genome of a parental germline that arise during development could be underlying causes of many disease states in offspring. In males, sperm are the conduit for transmission of genetic and epigenetic information to the next generation and are formed by the complex process of spermatogenesis, which involves undifferentiated stem cell, differentiating, meiotic, and morphogenesis phases. This workshop will explore recent advances in understanding the biology of these different phases in a variety of animal models as well as how epigenetic and genetic abnormalities may underlie transmission of diseases and fertility disorder in humans. Invited talks and poster sessions that focus on cutting edge findings along with vibrant discussions and debates about controversies in the field will provide a rich intellectual atmosphere that is sure to have an important impact on how the biology of spermatogenesis is investigated for years to come.

Biology,    Stem-cell Research & Therapy

Fusion Conferences

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Biology,    Genomics and Bioinformatics