The main challenge for Latin American (LA) economies is to commit to, and sustain the implementation of, long-term reforms aimed at increasing competitiveness and promoting sustainable, inclusive and balanced development. An adequate response to this challenge will certainly require using the best available scientific knowledge and constant re-evaluation of the development process in light of the scientific findings. Therefore, it will be essential to enhance the scientific understanding, improve the long-term scientific assessments, strengthen the scientific capacities and ensure that the sciences are responsive to the emerging needs. The 3rd SDEWES LA Conference will be held in São Paulo, Brazil, from 24-28 July and it will be dedicated to the improvement and dissemination of knowledge on methods, policies and technologies for increasing the sustainability of development by de-coupling growth from natural resources and replacing them with knowledge based economy, taking into account its economic, environmental and social pillars. One of the main issues of the coming decades is to improve efficiencies by integrating various life supporting systems, using excess from one, as resource in other, and in exact moment when it is beneficial to all, integrating electricity, heating, cooling, transport, water, buildings, waste, wastewater, industry, forestry and agriculture systems. Sustainability being also a perfect field for interdisciplinary and multi-cultural evaluation of complex system, the SDEWES Conference has become a significant venue for researchers in those areas to meet, and originate, discuss, share, and disseminate new ideas, continuing to successfully cover multiple areas, with particular focus on LA region wherever possible.