The first 2022 IMS ICSDS will be a four-day conference to be held in Florence, Italy in December 2022. Its objective is to bring together researchers in statistics and data science from academia, industry and government in a stimulating environment to exchange ideas on the developments of modern statistics, machine learning theory, methods and applications in data science. The conference will consist of several plenary sessions, and about 50 invited, contributed and poster sessions; with a portion of invited sessions designated for young researchers. The expected size of the conference is 300-400 participants. The conference will present topics with broad appeal, including: deep learning, causal inference, precision medicine, unsupervised, semi-supervised and supervised learning, nonparametrics, Bayesian statistics, environment statistics, network and graphic models, recommender systems, bioinformatics, high-dimensional data, functional data, genomics, drug discovery, statistics computations, imaging, intrusion and fraud detection, etc.