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Fusion Conferences

The different epithelial stem/progenitor cells identified so far in the different regions of the lung interact with specific stromal, and physical/mechanical, niches. Some of these niches have recently been characterized. These niches dictate the quiescence of the epithelial stem/progenitor cells, as well as their re-entry into the cell cycle and subsequent differentiation. The mesenchyme, which gives rise to different stromal cell niches has so far been understudied during development, homeostasis, injury/repair and disease development. Similarly, the effects on stem cells of the physical/mechanical properties of their local environment are just beginning to be explored.

Stem cell niches in lung development, Stem cell niches in lung homeostasis and repair, Breaking niche regulation in lung cancer, Characterisation of epithelial and mesenchymal progenitor cell populations

Fusion Conferences

The germline provides an eternal cellular link between generations and is the source of genetic diversity and evolution of animal populations. In addition, perturbations in the epigenome or genome of a parental germline that arise during development could be underlying causes of many disease states in offspring. In males, sperm are the conduit for transmission of genetic and epigenetic information to the next generation and are formed by the complex process of spermatogenesis, which involves undifferentiated stem cell, differentiating, meiotic, and morphogenesis phases. This workshop will explore recent advances in understanding the biology of these different phases in a variety of animal models as well as how epigenetic and genetic abnormalities may underlie transmission of diseases and fertility disorder in humans. Invited talks and poster sessions that focus on cutting edge findings along with vibrant discussions and debates about controversies in the field will provide a rich intellectual atmosphere that is sure to have an important impact on how the biology of spermatogenesis is investigated for years to come.

Biologie,    Molekularbiologie