A deep immunological understanding of fungal infections is crucial in order to reduce the fungal impact on human health. Advances in the field of fungal immunology over the past few years have identified crucial factors that predispose patients to fungal infections, including genetic factors. Essential pathways in mucosal and systemic immune responses to fungi have been uncovered. Most importantly, the increasing knowledge in the immunology of fungal infections has initiated the development of novel therapeutic strategies aimed at improving antifungal immunity or suppressing detrimental immune pathways. Despite these advances, many questions about the complex interaction of fungi, microbiome, and immune system remain unanswered. Therefore, the Gordon Research Seminar provides a platform for early career scientists to build collaborations with clinicians and industry in order to translate fundamental research into personalized medicine and diagnostics for fungal infections.