Konferenzen  >  Biowissenschaften  >  Biologie  >  Israel

European Molecular Biology Organization – EMBO

Developmental neuronal remodelling is essential for establishing functional nervous systems across species. Remodelling involves specific elimination of existing connections, typically followed by strengthening of surviving synapses or even axon regrowth to develop new, adult-specific connections. While altered remodeling has long been suspected of contributing to neuropsychiatric conditions, such as autism, schizophrenia, and ADHD, studies only recently established firm molecular similarities between such disorders and developmental remodeling. Moreover, the mechanisms involved in developmental remodelling appear to be reiterated in neurodegeneration and during regeneration. Despite these significant advances in the field, many important questions remain open and will be discussed at this meeting.

Molekularbiologie,    Neurologie