Our society faces various grand challenges that it urgently needs to address over the coming years, such as mitigating climate change, combating environmental damage, and providing effective, affordable healthcare for everyone. Data science and Artificial Intelligence are expected to play a key role in successfully tackling many of these challenges. While recent progress in AI was driven mostly by empirical developments, we are entering now a new phase in which questions of trustworthiness, scalability, fairness, privacy, reproducibility, and explainability emerge as key factors. Fundamentally new ideas and approaches are needed to address these open problems, which will require a close collaboration between mathematicians, statisticians, computer scientists, and engineers. This workshop features an interdisciplinary group of exceptional scientists from across the world to present recent developments, foster new interactions, and create novel ideas for the solution of the aforementioned data science problems.