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1
Gordon Research Seminar — Metabolomics and Human Health
11 Mar 2023 - 12 Mar 2023 • Lucca (Barga), LU, Italy
Abstract:
In this Gordon Research Seminar, we will focus on emerging systems biology technologies and their integration with metabolomics for the study of human health and disease. We will discuss and examine recent advancements in the field and their impact on disease mechanisms, heterogeneity, and progression and their impact on precision medicine. We will further cover critical challenges and future perspectives as well as the development of new tools and technologies. As is the goal and philosophy of GRS, we will highlight work from young scientists and emerging experts and nurture the emergence of a vibrant community that will enable future advancement in this exciting and quickly developing field. We invite early career members from academia, industry, and regulatory agencies to attend this meeting.
Topics:
Systems Biology and Integrative Omics for Precision Medicine
Event listing ID:
1506592
2
Gordon Research Conference — Metabolomics and Human Health
12 Mar 2023 - 17 Mar 2023 • Lucca (Barga), LU, Italy
Abstract:
Metabolomics is the comprehensive study of the metabolome, the repertoire of metabolites present in cells, tissues, and body fluids. More recently, these metabolites are being implicated in the promotion of human health. The human metabolic profile is influenced by a number of factors including diet, genetics, environmental factors and the microbiome. Understanding the influence of these factors at a cellular and systemic level is key to deciphering the role of metabolites in human health and promotion of lifespan.In this Gordon Conference series, we highlight state of the art metabolomics technologies and how such technologies can be used to study Human health. The conference will cover exciting new applications in the field such as Precision Nutrition, Human Ageing, response to Therapies (Precision Medicine), Exposome and Human Health.
Topics:
Examining the Intersection Between Systemic and Cellular Metabolism and Lifestyle Factors to Understand Health and Disease
Event listing ID:
1506621
3
Bonn Conference on Mathematical Life Sciences
17 Apr 2023 - 20 Apr 2023 • Bonn, Germany
Organizer:
Hausdorff Center for Mathematics – hcm (Universität Bonn)
Abstract:
Mathematical modelling and analysis are nowadays essential for all fields of the life sciences, ranging from basic research to clinical application. To discuss the state of the field and potential future development, please join us in Bonn, April 17-20, 2023.
Topics:
Systems Biology, Integrative Pathway Modelling , Mathematical Image Analysis, Computational Immunology, Chemoinformatics and Computational Drug Design, Single Cell Analysis, Mathematical Biology, Dynamics of Cellular and Neuronal Networks, Modelling of Tumour Microenvironment, Computational Protein Modelling and Design
Event listing ID:
1531577
4
Mathematical Foundations of Biological Organisation
23 Apr 2023 - 29 Apr 2023 • Oberwolfach, Germany
Organizer:
Mathematisches Forschungsinstitut Oberwolfach (MFO, Oberwolfach Research Institute for Mathematics)
Event listing ID:
1494888
5
Mathematical Population Dynamics, Ecology and Evolution
24 Apr 2023 - 28 Apr 2023 • CIRM (Marseille Luminy), France
Organizer:
CIRM – Centre International de Rencontres Mathématiques
Event listing ID:
1502961
Related subject(s):
6
CMO/Banff Workshop — Statistical Challenges for Complex Brain Signals and Images
30 Apr 2023 - 05 May 2023 • Oaxaca, Mexico
Organizer:
Casa Matemática Oaxaca (CMO)
Abstract:
This workshop will focus on developing novel statistical methodology to analyze brain signals, which is crucial to understanding normal brain function and alterations associated with neurological and mental diseases. Brain signals are complex and are a reflection of the complexity of the unobserved brain processes. Thus, the primary considerations for developing statistical models are flexibility, generalizability, and incorporation of known biology. In this workshop, we will discuss the most recent challenges in this area and how the current methods need to be improved to better describe the observed brain signals.
Event listing ID:
1503612
7
CMO/Banff Workshop — Computational Biology meets Data Science
07 May 2023 - 12 May 2023 • Oaxaca, Mexico
Organizer:
Casa Matemática Oaxaca (CMO)
Abstract:
With the advances of high-throughput technologies, genomics and related fields are hitting the thick data era. Many problems in biology cannot be studied with traditional and exact methods, and the development and application of tailored methods to analyze rich and large-scale biological datasets are still lagging behind. In addition, diverse layers of knowledge in genomics, such as transcriptomics, epigenomics, proteomics and metabolomics need to be integrated and studied jointly with multi-omics approaches to unfold the complex mechanisms of biological systems and organisms. Sparked with creative solutions from data science, computational and data scientists can contribute to the development and implementation of innovative solutions to extract, wrangle, visualize, analyze and store complex data resulting from high-throughput technologies with efficient, transparent and reproducible analytical pipelines.
Event listing ID:
1503644
8
EMBO Practical Course — Computational molecular evolution
07 May 2023 - 18 May 2023 • Heraklion, Greece
Organizer:
European Molecular Biology Organization – EMBO
Event listing ID:
1498451
9
BIRS Workshop — Mathematical Methods in Cancer Biology, Evolution and Therapy
14 May 2023 - 19 May 2023 • Banff, Alberta, Canada
Organizer:
Banff International Research Station (BIRS) for Mathematical Innovation and Discovery
Abstract:
Present day biology generates a wealth of data from which tumor biology and tumor evolution can be inferred, and therapeutic strategies can be developed. Most clinical (and research) samples are comprised of a mixture of different cells, including multiple different populations of cancer cells (‘subclones’) and a variety of normal cell types. Effective use of these data thus requires data from individual cell types to be deconvolved. A number of subfields are independently developing mathematical and statistical deconvolution techniques. While at first glance these subfields are largely disparate, there are clear opportunities for synergies to be developed. This workshop will fill this gap by bringing together researchers from several of these fragmented subfields across a wide range of backgrounds (computational biology, mathematics, statistics, computer science, biomedicine, etc.) to provide a synergistic forum for cross-disciplinary learning, discussion and collaboration.
Event listing ID:
1499013
Related subject(s):
10
EMBO Workshop — Systems biology: Linking chromatin and epigenetics to disease and development
25 May 2023 - 29 May 2023 • Alexandroupoli, Greece
Organizer:
European Molecular Biology Organization – EMBO
Abstract:
After recent advances in the field of molecular biology and genetics accompanied by the breathtaking progress in multi-omic strategies, have led to the development of Systems Biology in the last 5 years. Holistic approaches enable a refined approach to study the dynamic interactions between the components of the nucleus, the cell and its environment, ultimately leading to understanding the biological networks and the properties of biological systems. Recent advances, such as reaching the unprecedented resolution of individual cells combined with the use of new systems biology approaches, allow to address long standing questions, especially in the fields of disease and development. Thus, this EMBO Workshop will bring together world-class experts and young scientists in the fields of Systems Biology, Chromatin and Epigenetics for four full days to discuss their exciting recent findings as well as the future directions of these fields. The topics of the EMBO Workshop are sufficiently covered by the outstanding speakers. This EMBO Workshop has a unique focus and will allow all participants to receive a coherent, updated and original view of how the interplay of Systems Biology, Chromatin and Epigenetics will advance our understanding of development and disease, important areas that hold the keys for future therapeutic approaches.
Abstract submission deadline:
15 Mar 2023
Event listing ID:
1498491
Related subject(s):
11
Mathematical and Computational Biology
12 Jun 2023 - 16 Jun 2023 • Providence, Rhode Island, United States
Organizer:
ICERM
Abstract:
The field of mathematical and computational biology is rapidly growing. The most applicable computational models have been developed in collaboration between computational and life science researchers. This workshop aims to bring these groups together to facilitate and promote collaborations among them. A mathematical model for one disease might also be useful in modeling another disease. Some researchers are working on theoretical mathematical & statistical problems related to biological and biomedical applications, while others are developing computational methodologies to address fundamental life science knowledge gaps. This workshop fosters and features collaborations among these groups along with experimentalists and physicians. Theoreticians will be exposed to a variety of open biological questions in need of state-of-the-art and efficient mathematical methods. Computational scientists will learn about more robust and efficient methods that could be tailored to answer biological problems.
Contact:
Program Staff;     Phone: [1-401-863-5030];     Email: programstaff@icerm.brown.edu
Event listing ID:
1515213
Related subject(s):
12
BIOMATH 2023 — International Conference on Mathematical Methods and Models in Biosciences
18 Jun 2023 - 23 Jun 2023 • Pomorie, Bulgaria
Abstract:
Biomath 2023 is devoted to recent research in life sciences based on applications of mathematics as well as mathematics applied to or motivated by biological studies. It is a multidisciplinary meeting forum for researchers who develop and apply mathematical and computational tools to the study of phenomena in the broad fields of biology, ecology, medicine, biophysics, biochemistry, pharmacokinetics, chemoinformatics, biotechnology, bioengineering, environmental science, etc.
Event listing ID:
1537366
13
EMBO Practical Course — Computational modelling of multicellular systems
18 Jun 2023 - 23 Jun 2023 • Barcelona, Spain
Organizer:
European Molecular Biology Organization – EMBO
Event listing ID:
1528199
Related subject(s):
14
EMBO Workshop — Systems approaches in cancer
26 Jun 2023 - 30 Jun 2023 • Split, Croatia
Organizer:
European Molecular Biology Organization – EMBO
Event listing ID:
1528103
Related subject(s):
15
BIRS Workshop — Single-cell plus – data science challenges in single-cell research
02 Jul 2023 - 07 Jul 2023 • Banff, Alberta, Canada
Organizer:
Banff International Research Station (BIRS) for Mathematical Innovation and Discovery
Abstract:
Cells are the fundamental building blocks of life. Recent advancement in biotechnology has allowed us to peek inside this every cell for better understanding of biology and human disease. Single-cell technology also generates big and complex data and brings about new data science challenges for computational and life scientists. The objective of this workshop is to bring together international leaders in diverse disciplines including mathematical, statistical, computational, biological and medical in a collaborative atmosphere to develop the collaborative capacity that will tackle various underlying data science challenges in single-cell research.
Event listing ID:
1499104
16
Summer School MMVW01 — Summer School on Mathematics of Movement
17 Jul 2023 - 21 Jul 2023 • Cambridge , United Kingdom
Organizer:
Isaac Newton Institute for Mathematical Sciences (INI)
Abstract:
The aim of this summer school is to foster the development of a community of quantitative scientists who, while working on different application areas, share their knowledge and help address fundamental questions in the mathematics of movement. The goal is to identify common challenges and cross-fertilise concepts and techniques for modelling and analysing movement data in animal ecology and cell biology. With basic, as well as advanced, topics on the mathematics of movement the summer school welcomes early career researchers who that are new novice to the area but also those who that are already familiar with it. The first three days will be dedicated, respectively, to (i) Data Acquisition and Technology, (ii) Data Analysis, and (iii) Modelling, while the 4th and 5th days will be spent working in separate groups on specific dataset and modelling challenges. There will be sessions for early career presentations and poster sessions, as well as opportunities to hear about successful interdisciplinary collaborations and various activities to enable networking with the programme organisers and the many academic participants of the programme. There will also be a competition for the best poster.
Event listing ID:
1519675
17
EMBO | EMBL Symposium — Theory and concepts in biology
18 Jul 2023 - 21 Jul 2023 • EMBL Heidelberg and Virtual, Germany
Abstract:
Recent progress in biology has led to an explosion of factual knowledge about the living world over a huge range of scales in space and time. Yet, many questions about how to make sense of this data remain across the entire diversity of the living world from the smallest bacterium to the ecosystems of the Serengeti. This meeting aims to bring together a diverse collection of researchers interested in finding ways to parlay this ever-increasing factual knowledge into a corresponding array of conceptual knowledge. The goal of this symposium is to assemble an interdisciplinary community and to provide a platform to discuss perspectives on the role of theory in biology, and importantly also vice versa, the impact that biology can have on theory.
Event listing ID:
1528010
Related subject(s):
18
EMBO Practical Course — Plasticity in developing systems: Time, space and environment
24 Jul 2023 - 04 Aug 2023 • Heidelberg, Germany
Organizer:
European Molecular Biology Organization – EMBO
Event listing ID:
1528088
Related subject(s):
19
MORPHO23 — Dynamics of Self-Organization in Animal and Plant Development
24 Jul 2023 - 25 Aug 2023 • Santa Barbara, United States
Organizer:
Kavli Institute for Theoretical Physics, University of California, Santa Barbara
Abstract:
During animal and plant development, cells self-organize into complex organisms, through the gradual refinement of cellular identities and their arrangement in space. This is an iterative process, which progresses through successive rounds of symmetry breaking, accompanied by changes in molecular and mechanical properties that feed back across multiple scales. Many of the elementary processes underlying developmental patterning and morphogenesis are now well documented, and a growing array of tools is available to observe and manipulate their dynamics. Yet, we lack a set of general principles that explain how they are coordinated in space and time to produce a defined outcome, and comprehensive synthetic approaches that use such principles to recapitulate development in vitro. This program will bring together experimentalists and theoreticians to work towards an integrated view of self-organization. This requires that we examine how the collective dynamics of development emerge from individual cellular behaviors - how cellular decisions in high-dimensional gene expression landscapes are coordinated in patterning, and how cellular force generation and mechanical feedbacks provide a substrate for tissue-scale communication and morphogenesis. Unifying these different processes, the notion of information may provide a common currency for the molecular and mechanical cues that guide development, encouraging us to consider that information is not only conveyed and interpreted but also self-organizes.
Topics:
morphogenesis, development, plant development, self-organization, theory, quantitative biology, biophysics
Event listing ID:
1501639
Related subject(s):
20
Workshop MMVW02 — Collective Behaviour
07 Aug 2023 - 11 Aug 2023 • Cambridge , United Kingdom
Organizer:
Isaac Newton Institute for Mathematical Sciences (INI)
Abstract:
Modelling collective group movement in animal ecology and cell biology has, over the years, followed two relatively parallel modelling paths. Most prevalent for the former are what one might define as discrete level models, whereby computational constructs are used to keep track of the spatio-temporal dynamics of each individual in a group. Problems in the latter, cell biology, have been tackled mostly by continuous models whereby the details of the individuals are neglected, in favour of a description of the entire population through, e.g. a density function. However, more recently hybrid agent-based/population models have gained increasing usage.

As the overall aim of the workshop is to create an overarching modelling framework with which to interpret common empirical features, the exchange of ideas and techniques from the different communities is an invaluable opportunity to move forward and at the same to delineate the boundaries of applicability of the different approaches in collective movement research.

Event listing ID:
1519677
21
EMBO Lecture Course — Venice Summer School: The future of evolutionary-developmental systems biology
21 Aug 2023 - 25 Aug 2023 • Venice, Italy
Organizer:
European Molecular Biology Organization – EMBO
Abstract:
Any adequate theory of evolutionary change must cover both the sources and the consequences of phenotypic variation. On the one hand, we must understand the various processes—genetic, metabolic, physiological, developmental, and behavioral—that generate variation. On the other hand, we must understand the sorting processes that lead to the differential survival of different variants. The latter aspect is covered by traditional evolutionary genetics, with its well-developed set of concepts and models. In contrast, there seems to be no overarching theory or unifying framework able to explain the enormous diversity of processes generating variation. These processes are not only dauntingly complex, but also occur at many different levels of organization—from the molecular to the cellular, tissue, organ, organismic, and even supra-organismic levels (ecological or social). We could conclude from this that no theory of the sources of variation is possible, or we could call for a novel, empirically grounded, organismic systems biology that integrates philosophical, mathematical, and experimental approaches to tackle the issue. We will look at this project from a broad theoretical vantage point to assess the future of evolutionary and developmental systems biology.
Abstract submission deadline:
31 Mar 2023
Event listing ID:
1528003
Related subject(s):
22
BIRS Workshop — Mathematical Methods for Exploring and Analyzing Morphological Shapes across Biological Scales
03 Sep 2023 - 08 Sep 2023 • Banff, Alberta, Canada
Organizer:
Banff International Research Station (BIRS) for Mathematical Innovation and Discovery
Abstract:
The advances in imaging techniques have enabled the access to 3D shapes present in a variety of biological structures: organs, cells, organelles, and proteins. Since biological shapes are related to physiological functions, biomedical analyses are poised to incorporate more morphological data. For example, at the macroscopic scale, characterizing brain morphologies allows clinicians to quantify the progression of Alzheimer's disease. At the microscopic scale, the characterization of protein morphologies allows biologists to understand how these biomolecules react to chemical variations of their environment and helps detect promising pharmacological targets for the treatment of conditions ranging from neurological disorders to several cancers. Therefore, different biological scales ask a common statistical question: how can we build mathematical and statistical descriptions of biological morphologies and their variations? This workshop invites participants from different application fields to exchange mathematical and statistical methods for the study of biological shapes.
Event listing ID:
1499259
23
Workshop SPLW02 — Active mechanics, cell walls, growth, damage, feedback and morphological control
04 Sep 2023 - 08 Sep 2023 • Cambridge , United Kingdom
Organizer:
Isaac Newton Institute for Mathematical Sciences (INI)
Event listing ID:
1519601
24
BIRS Workshop — Mechanics of Cells and Polymer Networks: Bridging Theory, Simulation and Experiment
10 Sep 2023 - 15 Sep 2023 • Banff, Alberta, Canada
Organizer:
Banff International Research Station (BIRS) for Mathematical Innovation and Discovery
Abstract:
The interface between biology and quantitative disciplines including physics, mathematics and engineering is rapidly expanding. This is the result of many factors, but is largely driven by higher resolution spatial and temporal data from cutting edge imaging techniques, and increasing success in applying physical modeling techniques to biological problems. Mechanobiology is an especially rapidly developing field at the quantitative biology interface. This field describes how force is generated in biological systems, how force impacts chemistry, and how force generation is controlled by intracellular signaling pathways. Numerous feedforward and feedback interactions connect forces in cells to the dynamics of proteins and gene expression, resulting in highly nonlinear systems with complex and often non-intuitive behaviours.
Event listing ID:
1499247
25
Workshop MMVW03 — Measures and Representations of Interactions
11 Sep 2023 - 15 Sep 2023 • Cambridge , United Kingdom
Organizer:
Isaac Newton Institute for Mathematical Sciences (INI)
Abstract:
The study of interactions among living entities covers broad scientific domains, ranging from molecules and cells through individual organisms and groups to species, populations and communities. Common to all domains is the need to quantify the presumed interactions at the relevant spatial and temporal scales. While no formal theory exists in the literature, there exist different approaches that aim to construct a mechanistic representation of how individuals interact with each other as well as how to measure such interactions, but in most cases such approaches are specific to the problem at hand. The common factor among the existing approaches is their intention to represent the sequential nature of how organisms interact, first acquiring information from their surroundings, then processing that information and subsequently selecting a movement response.

By cross-fertilising different ideas and techniques in animal ecology and cell biology we aim to gain a more realistic perspective on measurement and representation of organism interactions, revisiting existing concepts, and permitting new discoveries and insights.

Event listing ID:
1519635
26
RESOLUTE — Unlocking Transporters For Drug Discovery
27 Sep 2023 - 29 Sep 2023 • Vienna, Austria
Organizer:
The ReSOLUTE-IMI Consortium
Abstract:
The RESOLUTE and REsolution consortia of the Innovative Medicines Initiative of the European Union have been empowering over the last years the scientific community with novel research tools and datasets for transporters of the Solute Carrier (SLC) supergroup. In 2023, both projects are coming to an end, and we would like to finish with a big celebratory and future-looking conference: “Unlocking Transporters for Drug Discovery”. At the event expect to see presented the results and lessons learned by the RESOLUTE and REsolution consortia over the last five years. Furthermore, top international scientists interested in metabolism and its regulation, drug discovery, the function and structure of membrane proteins will be speaking.
Contact:
RESOLUTE Communications Manager;     Email: contact@re-solute.eu
Topics:
transporters, solute carriers, SLC, genomics, metabolomics, proteomics, systems biology, data integration, drug discovery, medicine, variants, mutants, structural biology, resources, bio-tools, cell lines, plasmids
Event listing ID:
1538188
27
Workshop SPLW03 — Biological condensates: cellular mechanisms governed by phase transitions
09 Oct 2023 - 13 Oct 2023 • Cambridge , United Kingdom
Organizer:
Isaac Newton Institute for Mathematical Sciences (INI)
Event listing ID:
1519593
28
Vascular and Metabolic Modeling of the Brain at Large Scale
10 Oct 2023 - 20 Oct 2023 • Université de Montréal, Canada
Organizer:
Centre de recherches mathématiques (CRM)
Abstract:
While brain function originates in neuron, its energy is supported by the vascular system. With the recent development of anatomically detailed synthetic network models of the entire cerebral circulation, it is now possible to perform detailed simulations of physiology in realistic brains of small animals and humans on the computer. Modeling microcirculatory blood flow as a biphasic suspension of red-blood-cell and plasma, blood pressure, flow and hematocrit can be simulated in whole brains on the computer. Combining Poiseuille’s hemodynamic simulations with advection/diffusion equations describing oxygen diffusion, the human brain metabolism can now be modeled in-silico, by integrating tissue oxygen consumption and differential equations describing compartments associated with neural and glial brain cells. In parallel, energy metabolism regulation in the brain and its modeling has greatly progressed over the past few decades. This workshop will thus be focused on digital human brains, and their use to predict critical metabolic functions namely blood flow, oxygen extraction and cellular metabolism across all length scales down to the level of individual capillaries and cells. Courses and conferences will be combined with research presentations and practical workshops.
Event listing ID:
1531421
29
Mathematical biology
23 Oct 2023 - 27 Oct 2023 • CIRM (Marseille Luminy), France
Organizer:
CIRM – Centre International de Rencontres Mathématiques
Topics:
Ecology, epidemiology and evolution
Event listing ID:
1532407
30
Workshop MMVW04 — Modelling non-Markov Movement Processes
06 Nov 2023 - 10 Nov 2023 • Cambridge , United Kingdom
Organizer:
Isaac Newton Institute for Mathematical Sciences (INI)
Abstract:
The purpose of this workshop is to bring together scientists interested in different areas of complex movement in a biological context, from field research, to data analysis, to theoretical modelling. In particular, the focus will be on complex movement beyond the Markov property, such as memory-dependent animal foraging processes, spatial avoidance due to past deposition of animal scent or resource depletion, and directed motion in neutrophils. Despite its ubiquity, the mathematical difficulty in dealing with history dependence has hampered the study of non-Markov movement processes. Past empirical limitations are also responsible for the lack of a general theory to describe history dependent movement processes, as detection of features that would distinguish between Markov and non-Markov model predictions were not attainable. Currently, movement data may reach unprecedented resolution, and there is a renewed interest in developing non-Markov movement models, exemplified by recent theoretical studies to devise general prescriptions to simulate non-Markov stochastic processes.
Event listing ID:
1519572
31
BIRS Workshop — The Canadian Network for Modelling Infectious Diseases: Progress and Next Steps
12 Nov 2023 - 17 Nov 2023 • Banff, Alberta, Canada
Organizer:
Banff International Research Station (BIRS) for Mathematical Innovation and Discovery
Abstract:
What have we learned from the COVID-19 pandemic, and how can we be better prepared for the next global outbreak? This workshop brings together collaborative teams of modellers, statisticians, epidemiologists, genomics experts, public health decision-makers, and those implementing and delivering interventions who have been working together in a research network, aiming to increase Canada’s capacity for data-driven emerging infectious disease modelling to directly support future public health decisions. This BIRS meeting is an important opportunity for network members and collaborators to share the outcomes of their research over the two years since the network was launched with funding from the federal government. The questions being tackled at this workshop are grounded in public health needs and generated in partnership between research investigators and knowledge users – public health leaders, health administrators and policy-makers.
Event listing ID:
1499304
32
Inferring Neural Networks from Electrophysiological and Functional Imaging
20 Nov 2023 - 01 Dec 2023 • Université de Montréal, Canada
Organizer:
Centre de recherches mathématiques (CRM)
Abstract:
While network models have been studied as independent systems, efforts in neuroscience in recent years has been put towards inferring networks of the brain from imaging data. Using probabilistic methods and inverse models, recurrent networks across populations and their change with disease have been characterized based on input from electrophysiological and functional imaging.

This sub-theme will cover the notions of network dynamics, discuss conceptual frameworks to model brain network topology and provide the latest progress in neural network inference from imaging data and associated methodological approaches at modeling networks of the brain.

Event listing ID:
1531453
33
EMBO Workshop — Computational models of life: From molecular biology to digital twins
26 Nov 2023 - 01 Dec 2023 • Sant Feliu de Guíxols, Spain
Organizer:
European Molecular Biology Organization – EMBO
Event listing ID:
1527763
Related subject(s):
34
EMBO Workshop — Computational structural biology
06 Dec 2023 - 09 Dec 2023 • Heidelberg – hybrid, Germany
Organizer:
European Molecular Biology Organization – EMBO
Event listing ID:
1527754
Related subject(s):


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Last updated: 14 January 2023