The virtual meeting’s main goals are to: drive scientific innovation via a systems-level breadth of experimental analysis; foster collaborations, intellectual exchange, and interdisciplinary approaches; and help build the next cohort of TGFβ scientists.Cutting-edge and forward-looking presentations, by researchers from around the globe, will be directed towards a fundamental understanding of the functions and mechanisms of TGFβ family signaling by addressing: 1) How these factors mediate context-specific and temporally specific signals to orchestrate complex developmental and physiological processes; 2) How aberrations in this signaling pathway lead to developmental abnormalities and human disease pathologies; 3) How this knowledge may be applied in the clinic. The conference will cover complexities of signaling from structural dissection of molecular interactions to systems biology analyses of signaling networks and the biological consequences of signaling modulation in health, aging, and disease. Topics include: Developmental dynamics, from stem cell regulation and cell specification to tissue patterning, Regulation of the immune, cardiovascular, neuronal, bone, and cartilage systems during formation, repair and homeostasis, and pathogenesis of disease, Aberrant signaling modulation during cancer development and metastasis, developmental disorders, and fibrosis, Development of therapeutic modulators and their clinical implementation. The conference covers nine sessions with two poster sessions and two poster flash sessions, a “Meet the Expert” session, and career development workshops. Keynote sessions will be presented by Joan Massagué, PhD (Sloan Kettering Institute), Caroline Hill, PhD (Francis Crick Institute) and Michael Elowitz, PhD (California Institute of Technology).