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European Molecular Biology Organization – EMBO

The Hedgehog morphogen pathway is a key signalling pathway in development and stem cell regulation. Hedgehog deregulation leads to developmental and neurological diseases and is a crucial driver of several cancers. The goal of this conference is to bring together experts working on the mechanism of action of Hedgehog signalling in Developmental Biology, Disease, and Signal Transduction. The meeting will focus on the recent structural, biochemical, and cell-biological studies that shed new light on the mechanisms by which the Hedgehog signal is received on target cells and the unexpected role of cholesterol as a second messenger. Moreover, the recent advances in understanding the molecular mechanisms underlying the Hedgehog morphogen biosynthesis, its release from cells into extracellular space, and the mechanisms involved in ligand reception will be discussed. We will also cover the most recent insights into Hedgehog-dependent control of cell proliferation and differentiation in processes that range from insect morphogenesis to vertebrate limb formation, neural tube development, and bone differentiation. 

European Molecular Biology Organization – EMBO

Molecular Biology,    Systems Biology and Computational Biology

This GRC will be held in conjunction with the "Wnt Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information. Conference Program The session topics for this conference are being developed by the conference chairs. Please check back regularly for updates to this information. Contributors Gordon Research Conferences National Institutes of Health - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ImmunoPrecise Antibodies STEMCELL Technologies Inc. PeproTech Inc. Pfizer, Inc. Bio-Techne JW Pharmaceutical Corporation Leap Therapeutics Conference Links Conference History Wnt Signaling (GRS) Contribute Financially to This Conference Conference Fees Similar Conferences Poster Information Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.