Conferences  >  Life Sciences  >  Genomics and Bioinformatics  >  United States

The 2023 GRS will focus on major areas pertaining to the design of RNA into rationally designed nanostructures. Sessions will follow the developmental pipeline from computational and structural design to use in applications as diagnostics, therapeutics, and materials. Challenges facing the field, including the cellular delivery of these formulations and the immune stimulation of nucleic acid-based nanostructures, will also be explored. The schedule will include talks on research findings as well as poster presentations to drive discussion on these topics and beyond.

Delivery, Design and Function of RNA Nanostructures

Pharmacogenomics, Personalized Medicine,    Molecular Biology

The 2023 GRC on RNA Nanotechnology will promote scientific exchange and cross-disciplinary collaborations among scientists working in RNA chemistry, biology, biophysics, medicine, engineering and biotechnology. The nine sessions will feature presentations on nucleic acid structure and assembly, RNA modification, synthetic biology, nanostructures, biomaterials, extracellular vesicles, therapeutics, diagnostics, and imaging. Each session will also include short talks selected from abstracts submitted by poster presenters. Ample opportunities for extended discussions will be provided after each presentation and during breaks.

RNA Self-Assembly, Packaging, Imaging and Therapeutics

Pharmacogenomics, Personalized Medicine,    Molecular Biology

Mechanisms and Consequences of Genome Instability

Biology,    Molecular Biology

Exposures to environmental and endogenous DNA damaging agents produce thousands to over a million DNA lesions and chemical modifications to the genome per cell every day. Perturbations in the cellular pathways that respond to DNA damage are linked to myriad human diseases across nearly every cell and organ type. Conversely, dysfunction in DNA damage responses presents new vulnerabilities that are being leveraged to selectively target tumors in a more efficacious and less toxic manner. This GRC will bring together researchers at all levels including principal investigators, lead scientists, postdoctoral fellows and graduate students from academia, government and industry, to share and discuss the latest cutting-edge research on mechanisms of genome maintenance and roles in human health.

Genome Maintenance: From Molecules and Mechanisms to Humans and Therapies

Biology,    Molecular Biology

The focus of this year’s meeting is the opportunities and challenges in working with high-throughput phenotyping data. High-throughput phenotyping data encompasses, but is not limited to: omics, sensor and imaging data, electronic health records, activity monitoring, and sequencing. We will discuss the insights we gain into genetics of complex traits using diverse datasets, the challenges we need to overcome, and the opportunities for future research. Statistical, computational, and experimental methods, as well as results stemming from their application, will be presented.

Opportunities and Challenges in Using High-Throughput Phenotyping in Quantitative Genetics and Genomics

The Quantitative Genetics and Genomics GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Leveraging High-Throughput Phenotyping Techniques to Study Complex Traits

Studies of the fundamental process of translating mRNA into a protein sequence have greatly advanced our understanding of underlying molecular mechanisms and in consequence their regulation and disease association. Research on mRNA translation involves a wide spectrum of methods from single molecule measurements to the phenotypical characterization of organisms. This GRS will provide a platform where young scientists investigating different aspects of protein synthesis can meet for discussions about experimental approaches, exchange ideas and start collaborations, as well as obtain advice on possible career paths.

Exploring Protein Synthesis from Molecule to Organism

The well-studied process of mRNA translation is fundamental to all biology, and the relevance of this process to disease is emerging rapidly. The 2023 Gordon Research Conference (GRC) on Translational Machinery in Health and Disease will provide a unique forum for both new and established investigators to discuss their latest findings on the relationship of protein synthesis to disease. This interdisciplinary conference will cover connections between translation and a broad range of diseases including cancer, neurological, metabolic, inflammatory, infectious, and mitochondrial disorders. Scientific sessions will highlight recent discoveries on the genetic and molecular disturbances of translation that underlie pathophysiology. Other talks will focus on new technologies to study translation, translation during stress, in pathogens, and in the microbiome. A major goal of this conference will be to foster interactions among scientists at all levels to stimulate data exchange and collaborations across disciplines. Ample time will be provided for formal discussions during the scientific sessions and time will also be set aside for informal discussions. Poster presentations as well as the selection of speakers from submitted abstracts will ensure participation from investigators at all stages of their career. In addition, this GRC will be preceded by a Gordon Research Seminar (GRS) on Translational Machinery in Health and Disease which will be open only to students and postdoctoral fellows. The GRS will complement the GRC and provide a forum for trainees from around the world to broaden their peer network and to explore new directions in translation research.

Protein Synthesis and Cellular Synergy

The focus of the 2023 GRS is epitranscriptomics, RNA and DNA editing and modifications. These modifications are highly abundant and naturally occurring in nearly all organisms. The GRS on RNA editing brings together graduate student and post-docs to discuss fundamental mechanisms of these modifications and their aberrations in health and disease. The GRS will have two poster sessions and oral talks will be selected from submitted abstracts. The synergistic arrangement of the GRS and GRC will provide multiple opportunities for trainees to build professional networks and foster scientific collaborations.

Diverse Roles of Nucleic Acid Modifications: Biological and Technological Advances in Health and Disease

Molecular Biology,    Biotechnology

The 2023 meeting is subtitled: “RNA/DNA editing and epitranscriptomics across biological systems”. Modifications to the common nucleosides found in DNA and RNA have been known for many years. However, recent advances in analytical techniques for their detection, along with a deeper understanding of the broad impact these modifications have on fundamental biological processes, including human disease, have caused a renaissance in their study. Indeed, we now know that nucleic acid modifications are common in various naturally occurring nucleic acids and influence gene expression, protein synthesis, cognition, innate and adaptive immunity, autoimmune disease and cancer. This meeting will bring together a diverse group of scientists with varying expertise with the common goal of sharing ideas and approaches that can advance our understanding of the many facets of nucleic acid modifications.

RNA and DNA Editing and Epitranscriptomics Across Biological Systems

Molecular Biology,    Biotechnology