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EMBL

This conference series has become known for exploring yeasts as models to study questions of general relevance to evolution and ecology. Experts will speak on a range of topics, including evolution theory, ecology, genetics, cell biology, genomics, systems biology, metabolic modelling and engineering. The focus of this conference will be on comparative and experimental strategies to explore evolutionary questions, from field studies to computer simulations to comparative genomics. Central evolutionary questions will be discussed, using yeast and a range of other species whose biology is well understood and to determine the degree to which that biology is conserved in more distantly related species. The aim is to move from correlative studies based on comparative work to more causal studies based on broad experimental support. This problem is particularly pressing in the age of cheap and easy sequencing.

Email: events@embl.de

Systems and synthetic biology, Evolutionary systems biology, Experimental evolution, Assembly and evolution of microbial communities, Evolution of complex traits

EMBO | EMBL

Before the genetic information stored in DNA can be used to direct cell growth and metabolism, it has to be transferred into RNA. Messenger RNAs (mRNAs) that code for proteins and noncoding RNAs are key components in the transmission of genetic information in all life forms – from viruses to complex mammalian organisms. Exciting recent findings now reveal a new layer of information added to RNAs in the form of chemical marks (the epitranscriptome) that play a critical role in gene expression control. Following the great success of the virtual 2020 edition of this long-standing symposium, we are looking forward to returning to an in-person meeting for 2022, bringing together leaders in the RNA field, post-docs and students, with the aim of disseminating and discussing the most recent results. The program will include, among others, sessions on transcription, RNA processing and modification, mRNA export and localisation, mRNA surveillance and decay, translation and the control of mRNA expression by microRNAs.

Email: events@embl.de

Transcription, RNA processing, Export and localisation, mRNA surveillance and decay, Translation and the control of mRNA expression by microRNAs, RNA modifications Non-coding RNAs

European Molecular Biology Organization – EMBO

Metagenomics studies are rapidly uncovering the compositional richness of microbial communities in diverse habitats ranging from the oceans to the human gut. While their fundamental role in our health and environment is undeniable, there is an urgent need for unravelling molecular mechanisms underlying the dynamics of these communities. This requires a combined experimental and computational approach. Recent studies (including those from the organisers’ and speakers’ labs) have underlined the success of such integrative approaches. For example, emergence of cell subpopulations (Varahan et al. eLife 2019, 2020), and long-term stability (Blasche, Kim et al. Nat Microbiol. 2021) through metabolic cross-feeding. As researchers world-wide map species dynamics in the ecosystems of their interest, this course will provide the necessary overview and tools for moving from cataloguing to identifying key interaction agents, especially metabolites. This will include integrating species and metabolite dynamics data, as well as leveraging the power of genome-scale metabolic models to predict community interactions.

European Molecular Biology Organization – EMBO

The regulatory network known as the cell cycle is fundamental to the life of all eukaryotic organisms. The challenge in cell division research is to understand the mechanistic principles of the key processes and to integrate them into a cyclical or linear sequence generating viable daughter cells. Cell cycle research has succeeded in ordering these processes into a generic or “text book” cycle. However, this concept does not reflect the remarkable ability of the cell cycle “engine” to orchestrate a variety of cell divisions. These include not only embryonic, somatic, and meiotic divisions, but also divisions controlled by developmental context or physical factors, and the aberrant divisions of cancer cells. The EMBO Cell Cycle Workshop 2022 will therefore emphasise the question of how the basic cell cycle machinery is modified to generate different types of divisions. Working across different model systems and approaches, the cell division field has recognized the need for a common “language” in the form of mathematics and physics. This EMBO Workshop will therefore promote exchange between numerous disciplines to generate a new understanding of how the cell cycle creates the diversity of life.

EMBO | EMBL

This symposium aims to bring together a diverse group of scientists to discuss phenotypic, developmental and transgenerational plasticity from a wide range of disciplines and perspectives, focusing on its underlying molecular mechanisms and its role in driving evolutionary novelty. The meeting is designed to provide an interactive platform for scientists who share a common interest in plasticity but usually do not meet, within an intensive conference setting.

Email: events@embl.de

European Molecular Biology Organization – EMBO

Postponed from 7–12 November 2021

European Molecular Biology Organization – EMBO

This EMBO practical course will give a practical introduction to integrative structural biology. Through lectures and hands-on practicals, the participants will learn about the fundamentals of X-ray crystallography, cryo-EM, small-angle X-ray scattering, NMR, and structural mass spectrometry. The invited tutors will show how to analyze and interpret the experimental data, and how to use the data for building structural models across different resolution scales. The course will also explore how experimental and computational methods aiming at resolving dynamics can be integrated to characterize flexibility in macromolecular structures. Finally, we will discuss the future of integrative structural biology approaches in light of the most recent advances in experimental and computational methods.

EMBO | EMBL

Neurovascular biology is a young, emerging field that aims to unravel the molecular communication between the nervous system and the vasculature. Both the nervous system and the vascular system share striking conceptual similarities in the assembly of cellular networks through guided growth and branching processes. Vascular and neural cells work together to form a number of functional tissue compartments. Endothelial cells, certain mural support cells (i.e., pericytes), astrocytes and neurons assemble the neurovascular unit, which establishes the blood-brain and blood-retina barriers. In fact, many of the most debilitating neurodegenerative diseases and cognitive decline involve disruption of the neurovascular unit or compromised vascular function in the nervous system. It has become increasingly clear that the endothelium and mural support cells function go beyond nutrient supply and are instructive and structurally required to allow nervous system function. In this symposium, we bring together researchers from vascular biology and neurobiology to foster interdisciplinary exchange and new emerging concepts on how vascular and nervous systems crosstalk to maintain organ homeostasis and function.

Email: events@embl.de

Vessel-neuronal structure, Neurovascular signalling, Blood-brain barrier, Neurovascular coupling, Glymphatics, Neurovascular pathology

EMBL

Recent advances in genomics and proteomics technologies have transformed our ability to study diverse molecular processes. We can now use these technologies to study and understand mechanisms regulating transcription, translation, protein abundance, protein-protein, protein-metabolites and protein-drug interactions at a genome- and proteome-wide scale. The current challenge is to convert this data into predictive quantitative models of cellular processes. This massive task requires intensive integration of basic biology, genomics, proteomics, imaging, computational biology, mathematics, engineering and physics. This conference brings together scientists from diverse fields to promote cross-disciplinary collaborations and form a synthesis of appropriate systems-level approaches. We aim to get people out of their comfort zones, to hear new cutting-edge research in diverse areas to form new ideas. Over the past decade, this conference has served as an important venue to help shape the field and to generate a community of scientists that come from very diverse disciplines, each with the common goal to understand the systems level properties of their system of interest.

Email: events@embl.de

Single cell genomics, Quantitative genomics, Quantitative imaging, Quantitative proteomics

Registration is not yet open for this event. If you are interested in receiving more information please register your interest.

Email: events@embl.de

The upcoming "Advances in Chemical Biology" conference will feature latest research from all hot topics in chemical biology. It covers the chemical biology of nucleic acids and proteins, peptides and carbohydrates and includes topics such as high-throughput assays, target identification, targeted synthesis concepts and phenotypic screening.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Correlative Light and Electron Microscopy (CLEM) allows precise localisation of an event of interest within cells and tissues. During this course, we will focus on a specific method that has been developed at EMBL that enables the location of fluorescent proteins with high accuracy at the ultrastructural level. The course will cover both the theory and practicals of high precision CLEM, as well as opportunities to discuss their research with CLEM experts and receive practical and troubleshooting advice.

Biology,    Microscopy

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

A rapidly increasing number of researchers aim to purify and identify extracellular vesicles and many methodologies to isolate and analyse these vesicles are available and have been implemented. This course will cover the basics, possibilities and limitations of different purification and characterisation techniques and will address strategies to understand their role in biomedical applications.

Postponed from 13 – 18 March 2022

MIAPbP - Munich Institute for Astro-, Particle and BioPhysics

Life, as we know it today, is characterized by a set of biophysical properties that include the ability to grow, divide and replicate, and evolve in complexity via selection and distinction. From a chemical perspective, such processes are realized by chemical reactions and assembly processes that turnover reactants, and this turnover is driven by the supply of mass and energy. From a theoretical perspective, this supply maintains the system away from thermodynamic equilibrium leading to continuous fluxes of energy and mass, even in the stationary state of the system. To engineer living systems or specific life-like processes, unified approaches are necessary that incorporate concepts from biophysics, system chemistry, and theoretical physics. This workshop aims to bring together scientists from these three fields to discuss the current challenges to engineering life-like processes. The workshop will provide a collaborative environment that includes plenary talks on the question “What is life?” and the related challenges to engineering it. Moreover, there will be sessions with interactive short talks and brainstorming sessions with plenty of time to freely gather and develop novel approaches to how to engineer life.

General Physics

Biophysics, Medical Physics,    Organometallic Chemistry, Coordination Chemistry

European Molecular Biology Organization – EMBO

Regulation of translation is key in the control of gene expression, playing a critical role in many biological and pathophysiological settings. In the last decade, methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes, however, the systems-wide analysis of translation remained an unsolved experimental challenge. The advent of ‘ribosome-profiling’ provided the methodological basis for comprehensive transcriptome-wide analyses of translation at sub-codon resolution by the precise and high-throughput determination of ribosomal positions on mRNA. Its application in a variety of organisms yielded novel insights into protein synthesis and its dynamic regulation, significantly advancing our understanding of the post-transcriptional regulation of gene expression.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO