Meetings/Workshops on Molecular Biology in Germany

European Molecular Biology Organization – EMBO

This conference is assembling world-leading experts from diverse fields including genomics, epigenetics, structural biology, developmental biology, immunology, cancer biology and neurobiology, to discuss the broad impacts of TEs on organismal biology.

Email: events@embl.de

Genomics and evolution, Transposon regulation, Transposition mechanisms, Physiological impacts

European Molecular Biology Organization – EMBO

The European Molecular Biology Laboratory (EMBL)

The regulation of mRNA translation is a process required to maintain cell homeostasis, and its malfunction can lead to disease. In recent years, advances in high-throughput and microscopy methods have revealed findings that challenge hitherto established dogmas, such as extensive translation in “untranslated” regions of a transcript, pervasive initiation from non-AUG codons, heterogeneity and specialization of the ribosome or specialized roles for ‘general’ translation factors. The influence of epitranscriptomics and physical transitions in translation, or the molecular mechanisms underlying ribosome quality control are just examples where rapid progress is impacting our view of translation.

It is also now clear that the mRNA is covered with RNA binding proteins (RBPs) that control its fate, some of which have dual functions as enzymes, revealing connections with metabolism that we still need to understand. Thus, translation cannot be seen anymore as an isolated process, but as one highly connected with other steps of gene expression and finely dependent on cellular context. Advance on these aspects will be featured, as well as the role of translation regulation in diseases as diverse as cancer, metabolic or neurological disorders.

Email: events@embl.de

EMBLProtein, Translation initiation, Ribosome, elongation, termination Metabolism and disease, RNP complexes, Interconnections and turnover, Methods and systems approaches

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

EMBO Workshop

The regulation of the transcriptome is key to cellular processes that underpin cell biology, development and tissue function. All classes of cellular RNA are subject to post-transcriptional modification, be it by direct chemical modification, editing or non-templated nucleotide additions. It is now emerging that the modification status of the transcriptome is dynamic and responsive to environmental/developmental cues. Together, this has elicited the realisation of an ‘epitranscriptome’ where post-transcriptional RNA modification coupled with recruitment of effector RNA binding proteins dynamically regulates genomic output. Importantly, mutations in setting or reading RNA modifications are causative of many human diseases or congenital disorders. This meeting aims to explore all aspects of this emerging topic, from methods development to molecular mechanism. Most importantly, the meeting will place an emphasis on the contribution of RNA modification to mammalian development, tissue homeostasis and disease.

Email: events@embl.de

RNA modification I (m6A), RNA modifications in stem cells and development, RNA modification II (m5C, m1A, 3’ terminal additions, etc), RNA modification pathways in physiology and pathology, Emerging concepts

EMBO | EMBL

Are you interested in oscillatory phenomena and biological dynamics? At this symposium, multiple disciplines will come together in order to discuss common mechanisms underlying the generation of oscillations. This meeting provides a unique platform for the emerging new community working at the interface between quantitative biology, complex oscillatory systems, and physics. Oscillations are abundant – from hormonal oscillations with periods of days and months, to genetic fluctuations in the range of hours (circadian clock, embryonic oscillators), and metabolic and biochemical oscillations in the order of minutes (glycolytic oscillations) and seconds (Calcium-dynamics) – oscillations are central to biology across different temporal and spatial scales.

Email: events@embl.de

Oscillation mechanisms across different scales: from circadian clock to embryonic oscillators to biochemical (metabolic) oscillations, Oscillation function: besides known clock functions, other emerging concepts of oscillatory dynamics as a basis for temporal signal encoding mechanisms, Quantitative/imaging approaches in order to study oscillatory dynamics, Synchronisation of coupled oscillators, such as coupled oscillators and, synchronisation in various contexts and at different scales, Mathematical modelling and computational approaches to oscillatory dynamics

EMBL

Registration is not yet open for this event. If you are interested in receiving more information please register your interest. The event is jointly organised by EMBL, Zeiss, The Francis Crick Institute and The VIB Ghent.

Email: events@embl.de

EMBO | EMBL

One of the major outcomes of research using model organisms is that we are far from knowing all the functions fulfilled by various organs in vertebrates or invertebrates. Deleting one gene at a time in a single cell type is at the origin of unprecedented progress in our understanding of how homeostasis is maintained at the level of an entire organism. As a result, modern physiology has slowly moved from a purely molecular discipline back to being a truly holistic one. This molecular, genetic and yet holistic approach to physiology has had an effect on energy metabolism, the control of blood pressure, the plasticity of cognitive and immune functions, as well as the multiple ways in which organs such as fat, bone or gut can exert control over other organs such as the brain. Symbiotic interactions with resident microbes have added a further dimension to the study of host physiology. This symposium aims to provide a high visibility platform to scientists who use modern molecular genetic tools to discover inter-organ communications, and therefore to illustrate how much our molecular and genetic understanding of whole-organism physiology has progressed in the last 20 years. Bringing together scientists interested in various aspects of a single discipline, whole-organism physiology, will foster interactions between researchers working in different fields in order to speed up the discovery of novel physiologies. This meeting will also directly address a central question: How can recent developments in whole-organism physiology pave the way to novel and adapted therapies for multiple degenerative diseases? Lastly, it will showcase an approach to modern biology that starts from a question paused at the level of the entire organism and is answered through genetic means at the molecular level.

Course and Conference Office;     Email: events@embl.de

Brain-body crosstalk, The gut and its microbes, Bone and blood signals, Fat and liver signals, Immune-metabolic crosstalk, Beyond hormones: non-canonical inter-organ communication

EMBO | EMBL

This symposium will build on the success of the first, focused conference on microbial carcinogenesis, an EMBO Workshop held in October 2019, which successfully began to connect the various research views regarding bacterial infections and human cancer. It will bring together key players and leading researchers from complementary fields, thereby comprehensively highlighting and discussing the various aspects of pathogen-induced carcinogenesis (ecology, immunology, metabolism, genomics and epigenetics, barrier function and defence etc.) from an interdisciplinary perspective. This conference will also provide a larger audience of young researchers and students with a stimulating platform to present their research, to network and to develop this emerging field further.

Course and Conference Office;     Email: events@embl.de

EIROforum

Email: events@embl.de

EMBO | EMBL

Liquid phase separation is emerging as a common biophysical basis underlying many important cellular functions. This conference will bring together scientists from soft matter polymer physics, molecular “un”-structural biologists, and biologists working in cell, developmental and neurobiology to increase the awareness for how important phase separation is for our understanding of many biological processes to explore the large repertoire of new tools generated by other disciplines that are ripe to be applied to complex problems related to phase separation to close the gap in human potential and transdisciplinary training to tackle the role of phase separation in biology

Email: events@embl.de

Liquid compartments in the cell, Molecular mechanisms of phase separation, Phase separation, a polymer physics perspective, Phase separation in developmental biology and non-linear signalling, The pathological face of phase separation, Protein structure in the condensed state, Phase separation in neurobiology

EMBO | EMBL

Environmental mechanics impact the behaviour of cells, which in turn modify their surroundings. These bi-directional cell-tissue interactions have important consequences for gene expression, cell fate and function and give rise to transient and permanent tissue modifications. These processes are key for immunity and homeostasis, but also play a role in pathological processes as they are critical for fibrosis, inflammation and cancer metastasis.This symposium will focus on the interplay of cells with their environment and will bring together clinicians, cell biologists and material scientists interested in mechanobiology at the molecular, cellular and tissue level to approach its role in human physiology and pathology from different perspectives and scales. We will specifically discuss new technological approaches from the field of material sciences that enable the study of mechanobiology in vivo and in vitro, keeping in mind their potential use in a more applied context.

Email: events@embl.de

EMBL

Malaria remains one of the most significant global public health challenges, with more than 200 million clinical cases worldwide each year. The lack of an effective licensed vaccine and the continual emergence of drug-resistant malaria parasites emphasizes the need for new control and prevention strategies. This need for innovation has become even more apparent with the disruption of global malaria control programs due to the COVID-19 pandemic and potential reversal of gains made over the last few decades. Generation of fundamental knowledge lies at the heart of developing new tools and innovations for malaria intervention. The malaria research community has a long history of being a highly collaborative field, reliant on diverse technologies, sharing of resources and dissemination of biological advances made. Accessibility and timely sharing of these advances through the establishment of new collaborations is therefore vital for the translation of new ideas into public health impact.

Email: events@embl.de

European Molecular Biology Organization – EMBO

EMBO | EMBL

The microtubule cytoskeleton is essential for a wide variety of cellular functions, such as chromosome segregation, directed vesicle and organelle transport, cell motility and cell polarity. Impaired microtubule function can lead to human diseases including cancer and neurodegenerative disorders. In recent years, interdisciplinary approaches embracing cell biology, genetics, molecular biology, biochemistry, biophysics, structural biology and mathematical modelling have made a tremendous impact on the microtubule field.

The progressive diversification of the microtubule field into subdomains has created the need for a strong meeting that unifies the community and brings together researchers from different disciplines interested in microtubule research. This symposium will continue the success of the EMBO Conference series “Microtubule Structure, Regulation and Function”, and the EMBL|EMBO Symposium series “Microtubules: From Atoms to Complex System”, which have been held every two years since 2010. The meeting will bring together early-career and established researchers from all over the world who are interested in microtubule biology and its impact on human health and disease. This tenth-anniversary meeting will feature inspirational keynote and landmark lectures, a large number of short talk opportunities selected from the submitted abstracts, lively poster sessions, and special activities focused on the visualisation of scientific results to support research, learning, and scientific communication.

Email: events@embl.de

Structural determinants of microtubule formation, Control of microtubule dynamics, Microtubules in cell division, Building cilia and centrioles, Cilia formation and function, Cytoskeletal cross-talk and spatial organisation, Microtubules in differentiated cells, Visualisation of scientific results, Emerging topics

EMBO | EMBL

This symposium will bring together researchers from diverse fields to enhance our understanding of the dissemination and metastatic colonisation of tumour cells. It will provide a unique opportunity for interdisciplinary exchange on current approaches and future collaborations on metastasis and its therapeutic challenges.

Course and Conference Office;     Email: events@embl.de

Metastasis initiating cells, circulating tumour cells, Motility and invasion, Transcriptional and epigenetic control of metastasis, Metastasis heterogeneity, EMT and plasticity, Metastasis signalling and latency, Metastasis imaging, tumour microenvironment and immune evasion

EMBL

Microfluidic tools have made recent biological and biomedical research leaps possible. At the physics, engineering, chemistry and biology interface, innovation in microfluidic approaches has positively impacted areas as diverse as nucleotide sequencing, functional genomics, single-cell and single-molecule studies, and biomedical diagnostics. Many of these applications – including next-generation sequencing devices – have been revolutionised by miniaturisation, paving the way for global gene analysis and hence transforming biology. Working on the pico- to nanoliter scale not only allows a high degree of parallelisation, but importantly offers superb spatiotemporal control. Small objects such as cells, or even discrete parts thereof, can be exposed to unique conditions, facilitating entirely novel approaches to inquiry in modern biology and chemistry. The EMBL Microfluidics Conference brings together top researchers and emerging research leaders to spark scientific exchange and create community. Topics spanning from fundamental physics & chemistry to device design and nascent biological applications will be presented, which should be of interest to everyone from experts in microfluidic design to users of the next-generation of microfluidic tools, and from academic scholars and trainees to industry colleagues.

Email: events@embl.de

Probing biology, Next-generation device design and emerging applications, Disease diagnostics, analytical chemistry and chemical synthesis, Single-cell and single-molecule analyses

EMBL

This symposium provides a discussion platform for all scientists interested in the biology of infection. Cell biologists, microbiologists and immunologists will discuss in joint sessions recent progress in our understanding of host-pathogen interactions. Talks will focus on common processes, rather than particular infectious agents or host cell types, and the strategies of all major types of pathogens in their interaction with plants and animals will be covered. A better understanding of infectious diseases will come from the simultaneous analysis of microbial and host variables, which may open new avenues for treatment and prevention strategies.

Email: events@embl.de

Sensing pathogens, The cell biology of infection, Fungus-host interactions, Cell-autonomous immunity, Pathological consequences of infection and inflammation, Microbiota and pathogen control

The EMBL Transcription and Chromatin meeting has a long-standing tradition in shaping the field of transcriptional regulation. The meeting brings together leading experts covering all aspects of transcription including cis-regulatory function, long range regulation, 3-dimensional looping, the basal transcriptional machinery, RNA polymerase regulation and function, nucleosome positioning, chromatin modifications, chromatin remodelling and epigenetic inheritance of transcriptional silencing. The meeting contains many talks selected from the abstracts that are interspersed with invited speakers, discussing the latest breakthroughs in transcriptional regulation. The conference is designed to promote interactive discussions at both the talks and poster sessions. Given the excellent line up of speakers and the meeting’s outstanding reputation, this is a ‘must’ attend for anyone interested in cutting edge research in transcription.

Course and Conference Office;     Email: events@embl.de

Activators, enhancer function, evolution and modelling, Long range transcriptional regulation and enhancers, General basal transcriptional machinery, Pol II function, pausing and the role of RNA in transcription, Chromatin modifications and transcription, Transcriptional regulation during cell fate decisions – stem cell reprogramming and normal embryonic development, Genome topology and three-dimensional regulation, Single cell quantification

EMBO

The conference sets the stage for the dissemination and exchange of new developments in diverse, hot fields within chemical biology. It is the largest and longest standing conference in the field, being a platform for inspiration, collaboration and networking for researchers in academia and industry. We aim to provide the possibility for every chemical biologist to meet and discuss with peers topics ranging from tool development to biological applications, from computational drug design to synthetic chemistry.

Course and Conference Office;     Email: events@embl.de

Drug and target discovery, Carbohydrates and (engineered) natural products, Chemical optogenetics, Origin of life, Sensing and probes, Protein modifications, Cellular reprogramming and synthetic biology

EMBO | EMBL

The study of population genetic variation and the sequencing of ancient DNA represent promising new avenues for investigating human history and our evolutionary past. Population-scale sequencing projects investigating human diversity have provided us with more than a million genome wide datasets that allowed new insights into patterns of human variation and mobility, while others have obtained genome wide data from thousands of ancient human skeletons, allowing the investigation of human evolution in action and providing direct insights into population genetic dynamics in situ. Large-scale genetic variation data sets can now be integrated with genomics data from ancient remains and history records to provide novel insights into human history, cultural evolution and the genetic history of societies. Ancient DNA was furthermore used to reconstruct genomic variation of historic pathogens as well as oral and gut microbiomes in order to provide molecular fossils to study microbial evolution through time. This meeting will involve scientists from genomics, bioinformatics, microbiology, anthropology, archaeology and historians and may initiate future interactions in this exciting and timely new research area that has the potential to change the way we think about our human past and how we might study genetic variation in the future.

Email: events@embl.de

EMBL

This conference series has become known for exploring yeasts as models to study questions of general relevance to evolution and ecology. Experts will speak on a range of topics, including evolution theory, ecology, genetics, cell biology, genomics, systems biology, metabolic modelling and engineering. The focus of this conference will be on comparative and experimental strategies to explore evolutionary questions, from field studies to computer simulations to comparative genomics. Central evolutionary questions will be discussed, using yeast and a range of other species whose biology is well understood and to determine the degree to which that biology is conserved in more distantly related species. The aim is to move from correlative studies based on comparative work to more causal studies based on broad experimental support. This problem is particularly pressing in the age of cheap and easy sequencing.

Email: events@embl.de

Systems and synthetic biology, Evolutionary systems biology, Experimental evolution, Assembly and evolution of microbial communities, Evolution of complex traits

EMBO | EMBL

Before the genetic information stored in DNA can be used to direct cell growth and metabolism, it has to be transferred into RNA. Messenger RNAs (mRNAs) that code for proteins and noncoding RNAs are key components in the transmission of genetic information in all life forms – from viruses to complex mammalian organisms. Exciting recent findings now reveal a new layer of information added to RNAs in the form of chemical marks (the epitranscriptome) that play a critical role in gene expression control. Following the great success of the virtual 2020 edition of this long-standing symposium, we are looking forward to returning to an in-person meeting for 2022, bringing together leaders in the RNA field, post-docs and students, with the aim of disseminating and discussing the most recent results. The program will include, among others, sessions on transcription, RNA processing and modification, mRNA export and localisation, mRNA surveillance and decay, translation and the control of mRNA expression by microRNAs.

Email: events@embl.de

Transcription, RNA processing, Export and localisation, mRNA surveillance and decay, Translation and the control of mRNA expression by microRNAs, RNA modifications Non-coding RNAs

EMBO | EMBL

This symposium aims to bring together a diverse group of scientists to discuss phenotypic, developmental and transgenerational plasticity from a wide range of disciplines and perspectives, focusing on its underlying molecular mechanisms and its role in driving evolutionary novelty. The meeting is designed to provide an interactive platform for scientists who share a common interest in plasticity but usually do not meet, within an intensive conference setting.

Email: events@embl.de

EMBO | EMBL

Neurovascular biology is a young, emerging field that aims to unravel the molecular communication between the nervous system and the vasculature. Both the nervous system and the vascular system share striking conceptual similarities in the assembly of cellular networks through guided growth and branching processes. Vascular and neural cells work together to form a number of functional tissue compartments. Endothelial cells, certain mural support cells (i.e., pericytes), astrocytes and neurons assemble the neurovascular unit, which establishes the blood-brain and blood-retina barriers. In fact, many of the most debilitating neurodegenerative diseases and cognitive decline involve disruption of the neurovascular unit or compromised vascular function in the nervous system. It has become increasingly clear that the endothelium and mural support cells function go beyond nutrient supply and are instructive and structurally required to allow nervous system function. In this symposium, we bring together researchers from vascular biology and neurobiology to foster interdisciplinary exchange and new emerging concepts on how vascular and nervous systems crosstalk to maintain organ homeostasis and function.

Email: events@embl.de

Vessel-neuronal structure, Neurovascular signalling, Blood-brain barrier, Neurovascular coupling, Glymphatics, Neurovascular pathology

EMBL

Recent advances in genomics and proteomics technologies have transformed our ability to study diverse molecular processes. We can now use these technologies to study and understand mechanisms regulating transcription, translation, protein abundance, protein-protein, protein-metabolites and protein-drug interactions at a genome- and proteome-wide scale. The current challenge is to convert this data into predictive quantitative models of cellular processes. This massive task requires intensive integration of basic biology, genomics, proteomics, imaging, computational biology, mathematics, engineering and physics. This conference brings together scientists from diverse fields to promote cross-disciplinary collaborations and form a synthesis of appropriate systems-level approaches. We aim to get people out of their comfort zones, to hear new cutting-edge research in diverse areas to form new ideas. Over the past decade, this conference has served as an important venue to help shape the field and to generate a community of scientists that come from very diverse disciplines, each with the common goal to understand the systems level properties of their system of interest.

Email: events@embl.de

Single cell genomics, Quantitative genomics, Quantitative imaging, Quantitative proteomics

Registration is not yet open for this event. If you are interested in receiving more information please register your interest.

Email: events@embl.de