Meetings/Workshops on Molecular Biology in Germany

EMBO | EMBL

Environmental mechanics impact the behaviour of cells, which in turn modify their surroundings. These bi-directional cell-tissue interactions have important consequences for gene expression, cell fate and function and give rise to transient and permanent tissue modifications. These processes are key for immunity and homeostasis, but also play a role in pathological processes as they are critical for fibrosis, inflammation and cancer metastasis.This symposium will focus on the interplay of cells with their environment and will bring together clinicians, cell biologists and material scientists interested in mechanobiology at the molecular, cellular and tissue level to approach its role in human physiology and pathology from different perspectives and scales. We will specifically discuss new technological approaches from the field of material sciences that enable the study of mechanobiology in vivo and in vitro, keeping in mind their potential use in a more applied context.

Email: events@embl.de

EMBL

Malaria remains one of the most significant global public health challenges, with more than 200 million clinical cases worldwide each year. The lack of an effective licensed vaccine and the continual emergence of drug-resistant malaria parasites emphasizes the need for new control and prevention strategies. This need for innovation has become even more apparent with the disruption of global malaria control programs due to the COVID-19 pandemic and potential reversal of gains made over the last few decades. Generation of fundamental knowledge lies at the heart of developing new tools and innovations for malaria intervention. The malaria research community has a long history of being a highly collaborative field, reliant on diverse technologies, sharing of resources and dissemination of biological advances made. Accessibility and timely sharing of these advances through the establishment of new collaborations is therefore vital for the translation of new ideas into public health impact.

Email: events@embl.de

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

EMBO | EMBL

The microtubule cytoskeleton is essential for a wide variety of cellular functions, such as chromosome segregation, directed vesicle and organelle transport, cell motility and cell polarity. Impaired microtubule function can lead to human diseases including cancer and neurodegenerative disorders. In recent years, interdisciplinary approaches embracing cell biology, genetics, molecular biology, biochemistry, biophysics, structural biology and mathematical modelling have made a tremendous impact on the microtubule field.

The progressive diversification of the microtubule field into subdomains has created the need for a strong meeting that unifies the community and brings together researchers from different disciplines interested in microtubule research. This symposium will continue the success of the EMBO Conference series “Microtubule Structure, Regulation and Function”, and the EMBL|EMBO Symposium series “Microtubules: From Atoms to Complex System”, which have been held every two years since 2010. The meeting will bring together early-career and established researchers from all over the world who are interested in microtubule biology and its impact on human health and disease. This tenth-anniversary meeting will feature inspirational keynote and landmark lectures, a large number of short talk opportunities selected from the submitted abstracts, lively poster sessions, and special activities focused on the visualisation of scientific results to support research, learning, and scientific communication.

Email: events@embl.de

Structural determinants of microtubule formation, Control of microtubule dynamics, Microtubules in cell division, Building cilia and centrioles, Cilia formation and function, Cytoskeletal cross-talk and spatial organisation, Microtubules in differentiated cells, Visualisation of scientific results, Emerging topics

European Molecular Biology Organization – EMBO

Humanized mouse engraftment models (human immune system and/or human tissue) are an integral part of basic and translational research for the understanding of human diseases and for development of new therapies. The Ebola Virus outbreak has demonstrated the relevance of humanized mouse models for the understanding of emerging diseases and testing new medicines. The same can apply for the Coronavirus (COVID-19) pandemic. “Big pharma” and biotech companies include humanized mice in their pre-clinical development portfolio to test efficacy and safety of anti-cancer drugs. These platforms provide researchers and drug developers with human specific targets, physiological pathways and mechanisms of disease not found in traditional mouse models of disease. These aspects of the humanized models allow direct testing of human versus mouse specific therapies enabling more rapid drug development and the generation of more clinically relevant data. During the last decade these models have substantially diverged among laboratories regarding the mouse strains used, mouse handling, analyses techniques and sources of human material. This experimental variability is expected as the field is dynamic and growing rapidly, but the data documentation and reporting should be better standardized for metadata analyses. This course will teach the participants the principles of experimental pre-requisites and harmonized analyses (e.g., flow cytometry, RNA sec and genomic analyses).

ecSeq Bioinformatics GmbH

In a nutshell:

- Learn the essential computing skills for NGS bioinformatics

- Understand NGS analysis algorithms (e.g. read alignment) and data formats

- Use bioinformatics tools for handling NGS data

- Perform first downstream analyses for studying genetic variation

- Compare different approaches for differential expression analysis

The purpose of this intense one week summer course is to get a deep understanding in Next-Generation Sequencing (NGS) with a special focus on bioinformatics issues. Advantages and disadvantages of current sequencing technologies and their implications on data analysis will be discovered. You will be trained on understanding NGS data formats and handling potential problems/errors therein. In the summer school we will use a real-life RNA-seq dataset from the current market leader illumina.

All students will be enabled to perform important first tasks of NGS data analysis themselves. The layout of the summer school has been adapted to the needs of beginners in the field of NGS bioinformatics and allows scientists with no or little background in computer science to get a first hands-on experience in this new and fast evolving research topic.

In the evenings there will be social events, like a conference dinner, or a guided city tour through Berlin. These are always great networking possibilities.

Events-Team;     Email: events@ecseq.com

RNA-Seq, DNA-Seq, NGS, sequencing, bioinformatics

Genomics and Bioinformatics,    Training in Computer Science, Courses

European Molecular Biology Organization – EMBO

The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

EMBO | EMBL

This symposium will bring together researchers from diverse fields to enhance our understanding of the dissemination and metastatic colonisation of tumour cells. It will provide a unique opportunity for interdisciplinary exchange on current approaches and future collaborations on metastasis and its therapeutic challenges.

Course and Conference Office;     Email: events@embl.de

Metastasis initiating cells, circulating tumour cells, Motility and invasion, Transcriptional and epigenetic control of metastasis, Metastasis heterogeneity, EMT and plasticity, Metastasis signalling and latency, Metastasis imaging, tumour microenvironment and immune evasion

Institute of Molecular Biology

Ageing is a challenge that affects all organisms. To cope with adversities that cause ageing, organisms have evolved protective mechanisms that promote resilience. These range from the molecular (e.g. biophysics of molecules, genetic and physiological) to the organismic (e.g. division of societal and ecological roles).

IMB Events Office;     Email: events@imb.de

Ageing, biological resilience, evolution of lifespan, genome stability, germ and stem cells and ageing, metabolism and the microbiome, regeneration, stress and ageing, phase separation.

EMBL

Microfluidic tools have made recent biological and biomedical research leaps possible. At the physics, engineering, chemistry and biology interface, innovation in microfluidic approaches has positively impacted areas as diverse as nucleotide sequencing, functional genomics, single-cell and single-molecule studies, and biomedical diagnostics. Many of these applications – including next-generation sequencing devices – have been revolutionised by miniaturisation, paving the way for global gene analysis and hence transforming biology. Working on the pico- to nanoliter scale not only allows a high degree of parallelisation, but importantly offers superb spatiotemporal control. Small objects such as cells, or even discrete parts thereof, can be exposed to unique conditions, facilitating entirely novel approaches to inquiry in modern biology and chemistry. The EMBL Microfluidics Conference brings together top researchers and emerging research leaders to spark scientific exchange and create community. Topics spanning from fundamental physics & chemistry to device design and nascent biological applications will be presented, which should be of interest to everyone from experts in microfluidic design to users of the next-generation of microfluidic tools, and from academic scholars and trainees to industry colleagues.

Email: events@embl.de

Probing biology, Next-generation device design and emerging applications, Disease diagnostics, analytical chemistry and chemical synthesis, Single-cell and single-molecule analyses

EMBL

This symposium provides a discussion platform for all scientists interested in the biology of infection. Cell biologists, microbiologists and immunologists will discuss in joint sessions recent progress in our understanding of host-pathogen interactions. Talks will focus on common processes, rather than particular infectious agents or host cell types, and the strategies of all major types of pathogens in their interaction with plants and animals will be covered. A better understanding of infectious diseases will come from the simultaneous analysis of microbial and host variables, which may open new avenues for treatment and prevention strategies.

Email: events@embl.de

Sensing pathogens, The cell biology of infection, Fungus-host interactions, Cell-autonomous immunity, Pathological consequences of infection and inflammation, Microbiota and pathogen control

The EMBL Transcription and Chromatin meeting has a long-standing tradition in shaping the field of transcriptional regulation. The meeting brings together leading experts covering all aspects of transcription including cis-regulatory function, long range regulation, 3-dimensional looping, the basal transcriptional machinery, RNA polymerase regulation and function, nucleosome positioning, chromatin modifications, chromatin remodelling and epigenetic inheritance of transcriptional silencing. The meeting contains many talks selected from the abstracts that are interspersed with invited speakers, discussing the latest breakthroughs in transcriptional regulation. The conference is designed to promote interactive discussions at both the talks and poster sessions. Given the excellent line up of speakers and the meeting’s outstanding reputation, this is a ‘must’ attend for anyone interested in cutting edge research in transcription.

Course and Conference Office;     Email: events@embl.de

Activators, enhancer function, evolution and modelling, Long range transcriptional regulation and enhancers, General basal transcriptional machinery, Pol II function, pausing and the role of RNA in transcription, Chromatin modifications and transcription, Transcriptional regulation during cell fate decisions – stem cell reprogramming and normal embryonic development, Genome topology and three-dimensional regulation, Single cell quantification

European Chemoreception Research Organization

The goal of ECRO is to promote fundamental and applied research in chemosensory science especially olfaction and taste in vertebrates and invertebrates. ECRO organizes a annual congress to that end. ECRO is financed by individual member subscriptions and by donations from industry and research institutions. To facilitate participation of younger scientists ECRO supports travel grants for students.

European Molecular Biology Organization – EMBO

Experience modern cell biology at work: not only see but also try out in practice how cutting-edge technologies can be used to answer questions at the frontiers of cell biology. It is a tradition that the entire faculty of the Cell Biology and Biophysics Unit of EMBL teaches the course to cover a broad spectrum of techniques. The course also provides an excellent opportunity for participants and course faculty to discuss current and future challenges in cell biology.

EMBO

The conference sets the stage for the dissemination and exchange of new developments in diverse, hot fields within chemical biology. It is the largest and longest standing conference in the field, being a platform for inspiration, collaboration and networking for researchers in academia and industry. We aim to provide the possibility for every chemical biologist to meet and discuss with peers topics ranging from tool development to biological applications, from computational drug design to synthetic chemistry.

Course and Conference Office;     Email: events@embl.de

Drug and target discovery, Carbohydrates and (engineered) natural products, Chemical optogenetics, Origin of life, Sensing and probes, Protein modifications, Cellular reprogramming and synthetic biology

SFB877 "Proteolyse als ein regulatorisches Ereignis in der Pathophysiologie"

Das Symposium bringt internationale Fachleute zusammen, die sich mit dem Prozess der Proteolyse in der Signaltransduktion von Zellen beschäftigen. Diese Prozesse sind zentral in der Entzündung und Krebsentwicklung.

Phone: [+49 431 880 2018];     Email: pvoss@biochem.uni-kiel.de

Proteolysis, Regulation, Inflammation, Neurodegeneration, Cancer, Cell Death

European Molecular Biology Organization – EMBO

Synthetic Biology (SynBio) has become a rapidly developing area for tackling a large number of challenges in life science research. This course will provide the best and most exciting novelties in the field and focus on exploiting tools and concepts of SynBio for multi-scale engineering of bacterial systems. The course is directed to PhD students and early post-doctoral researchers active in the areas of molecular microbiology, bacterial biotechnology, systems biology and bioengineering.

EMBO | EMBL

The study of population genetic variation and the sequencing of ancient DNA represent promising new avenues for investigating human history and our evolutionary past. Population-scale sequencing projects investigating human diversity have provided us with more than a million genome wide datasets that allowed new insights into patterns of human variation and mobility, while others have obtained genome wide data from thousands of ancient human skeletons, allowing the investigation of human evolution in action and providing direct insights into population genetic dynamics in situ. Large-scale genetic variation data sets can now be integrated with genomics data from ancient remains and history records to provide novel insights into human history, cultural evolution and the genetic history of societies. Ancient DNA was furthermore used to reconstruct genomic variation of historic pathogens as well as oral and gut microbiomes in order to provide molecular fossils to study microbial evolution through time. This meeting will involve scientists from genomics, bioinformatics, microbiology, anthropology, archaeology and historians and may initiate future interactions in this exciting and timely new research area that has the potential to change the way we think about our human past and how we might study genetic variation in the future.

Email: events@embl.de

EMBL

This conference series has become known for exploring yeasts as models to study questions of general relevance to evolution and ecology. Experts will speak on a range of topics, including evolution theory, ecology, genetics, cell biology, genomics, systems biology, metabolic modelling and engineering. The focus of this conference will be on comparative and experimental strategies to explore evolutionary questions, from field studies to computer simulations to comparative genomics. Central evolutionary questions will be discussed, using yeast and a range of other species whose biology is well understood and to determine the degree to which that biology is conserved in more distantly related species. The aim is to move from correlative studies based on comparative work to more causal studies based on broad experimental support. This problem is particularly pressing in the age of cheap and easy sequencing.

Email: events@embl.de

Systems and synthetic biology, Evolutionary systems biology, Experimental evolution, Assembly and evolution of microbial communities, Evolution of complex traits

EMBO | EMBL

Before the genetic information stored in DNA can be used to direct cell growth and metabolism, it has to be transferred into RNA. Messenger RNAs (mRNAs) that code for proteins and noncoding RNAs are key components in the transmission of genetic information in all life forms – from viruses to complex mammalian organisms. Exciting recent findings now reveal a new layer of information added to RNAs in the form of chemical marks (the epitranscriptome) that play a critical role in gene expression control. Following the great success of the virtual 2020 edition of this long-standing symposium, we are looking forward to returning to an in-person meeting for 2022, bringing together leaders in the RNA field, post-docs and students, with the aim of disseminating and discussing the most recent results. The program will include, among others, sessions on transcription, RNA processing and modification, mRNA export and localisation, mRNA surveillance and decay, translation and the control of mRNA expression by microRNAs.

Email: events@embl.de

Transcription, RNA processing, Export and localisation, mRNA surveillance and decay, Translation and the control of mRNA expression by microRNAs, RNA modifications Non-coding RNAs

European Molecular Biology Organization – EMBO

Metagenomics studies are rapidly uncovering the compositional richness of microbial communities in diverse habitats ranging from the oceans to the human gut. While their fundamental role in our health and environment is undeniable, there is an urgent need for unravelling molecular mechanisms underlying the dynamics of these communities. This requires a combined experimental and computational approach. Recent studies (including those from the organisers’ and speakers’ labs) have underlined the success of such integrative approaches. For example, emergence of cell subpopulations (Varahan et al. eLife 2019, 2020), and long-term stability (Blasche, Kim et al. Nat Microbiol. 2021) through metabolic cross-feeding. As researchers world-wide map species dynamics in the ecosystems of their interest, this course will provide the necessary overview and tools for moving from cataloguing to identifying key interaction agents, especially metabolites. This will include integrating species and metabolite dynamics data, as well as leveraging the power of genome-scale metabolic models to predict community interactions.

EMBO | EMBL

This symposium aims to bring together a diverse group of scientists to discuss phenotypic, developmental and transgenerational plasticity from a wide range of disciplines and perspectives, focusing on its underlying molecular mechanisms and its role in driving evolutionary novelty. The meeting is designed to provide an interactive platform for scientists who share a common interest in plasticity but usually do not meet, within an intensive conference setting.

Email: events@embl.de

European Molecular Biology Organization – EMBO

Postponed from 7–12 November 2021

European Molecular Biology Organization – EMBO

This EMBO practical course will give a practical introduction to integrative structural biology. Through lectures and hands-on practicals, the participants will learn about the fundamentals of X-ray crystallography, cryo-EM, small-angle X-ray scattering, NMR, and structural mass spectrometry. The invited tutors will show how to analyze and interpret the experimental data, and how to use the data for building structural models across different resolution scales. The course will also explore how experimental and computational methods aiming at resolving dynamics can be integrated to characterize flexibility in macromolecular structures. Finally, we will discuss the future of integrative structural biology approaches in light of the most recent advances in experimental and computational methods.

EMBO | EMBL

Neurovascular biology is a young, emerging field that aims to unravel the molecular communication between the nervous system and the vasculature. Both the nervous system and the vascular system share striking conceptual similarities in the assembly of cellular networks through guided growth and branching processes. Vascular and neural cells work together to form a number of functional tissue compartments. Endothelial cells, certain mural support cells (i.e., pericytes), astrocytes and neurons assemble the neurovascular unit, which establishes the blood-brain and blood-retina barriers. In fact, many of the most debilitating neurodegenerative diseases and cognitive decline involve disruption of the neurovascular unit or compromised vascular function in the nervous system. It has become increasingly clear that the endothelium and mural support cells function go beyond nutrient supply and are instructive and structurally required to allow nervous system function. In this symposium, we bring together researchers from vascular biology and neurobiology to foster interdisciplinary exchange and new emerging concepts on how vascular and nervous systems crosstalk to maintain organ homeostasis and function.

Email: events@embl.de

Vessel-neuronal structure, Neurovascular signalling, Blood-brain barrier, Neurovascular coupling, Glymphatics, Neurovascular pathology

EMBL

Recent advances in genomics and proteomics technologies have transformed our ability to study diverse molecular processes. We can now use these technologies to study and understand mechanisms regulating transcription, translation, protein abundance, protein-protein, protein-metabolites and protein-drug interactions at a genome- and proteome-wide scale. The current challenge is to convert this data into predictive quantitative models of cellular processes. This massive task requires intensive integration of basic biology, genomics, proteomics, imaging, computational biology, mathematics, engineering and physics. This conference brings together scientists from diverse fields to promote cross-disciplinary collaborations and form a synthesis of appropriate systems-level approaches. We aim to get people out of their comfort zones, to hear new cutting-edge research in diverse areas to form new ideas. Over the past decade, this conference has served as an important venue to help shape the field and to generate a community of scientists that come from very diverse disciplines, each with the common goal to understand the systems level properties of their system of interest.

Email: events@embl.de

Single cell genomics, Quantitative genomics, Quantitative imaging, Quantitative proteomics

Registration is not yet open for this event. If you are interested in receiving more information please register your interest.

Email: events@embl.de