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European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Correlative Light and Electron Microscopy (CLEM) allows precise localisation of an event of interest within cells and tissues. During this course, we will focus on a specific method that has been developed at EMBL that enables the location of fluorescent proteins with high accuracy at the ultrastructural level. The course will cover both the theory and practicals of high precision CLEM, as well as opportunities to discuss their research with CLEM experts and receive practical and troubleshooting advice.

Biology,    Microscopy

European Molecular Biology Laboratory | EMBL

The cardiovascular system is a multicellular and disseminated organ consisting of the heart, a network of vessels and circulating blood, thereby forming an intricately interdependent system, whose dysfunction is the leading cause of human mortality. Despite translational progress with impactful new interventional and pharmacological therapies, cardiovascular dysfunction continues to plague mankind. The current therapeutic approaches are either organ-centric or tackle the consequences of end-stage cardiovascular disease (CVD). New basic research approaches are focused on a deeper understanding of the causes and early development of CVD to identify mechanisms close to the root of the disease, providing the promise to prevent, halt, and reverse the disease process. In parallel, new tissue engineering and mechanobiology approaches are revolutionizing cardiovascular discovery research and disease modeling by more closely mimicking the human situation. However, these are largely separated research communities, with yet little crosstalk or exchange between the two. This conference aims at transforming the established organ-centric view on single cardiovascular organs to a systems biomedicine approach by tearing down the walls between disciplines and instead discussing the cardiovascular system in an inter-, trans-, and cross-disciplinary approach. 

Biology,    Cardiology

European Molecular Biology Organization – EMBO

Host-microbe interactions can be positive or negative for both a host organism and its symbiotic microbes. Interacting with microbes can allow eukaryotes to acquire crucial functions, like nutrient production, but interactions can also be pathogenic in nature. This cross-disciplinary meeting will bring together scientists using cellular, molecular, ecological, physiological, and theory-based approaches to explore the evolution of intimate species-species interactions. Our aim is to understand the cellular systems and pathways that drive transitions in symbiotic states, for example, as partnerships move from pathogenesis to beneficial and back again.

European Molecular Biology Organization – EMBO

A rapidly increasing number of researchers aim to purify and identify extracellular vesicles and many methodologies to isolate and analyse these vesicles are available and have been implemented. This course will cover the basics, possibilities and limitations of different purification and characterisation techniques and will address strategies to understand their role in biomedical applications.

Postponed from 13 – 18 March 2022

MIAPbP - Munich Institute for Astro-, Particle and BioPhysics

Life, as we know it today, is characterized by a set of biophysical properties that include the ability to grow, divide and replicate, and evolve in complexity via selection and distinction. From a chemical perspective, such processes are realized by chemical reactions and assembly processes that turnover reactants, and this turnover is driven by the supply of mass and energy. From a theoretical perspective, this supply maintains the system away from thermodynamic equilibrium leading to continuous fluxes of energy and mass, even in the stationary state of the system. To engineer living systems or specific life-like processes, unified approaches are necessary that incorporate concepts from biophysics, system chemistry, and theoretical physics. This workshop aims to bring together scientists from these three fields to discuss the current challenges to engineering life-like processes. The workshop will provide a collaborative environment that includes plenary talks on the question “What is life?” and the related challenges to engineering it. Moreover, there will be sessions with interactive short talks and brainstorming sessions with plenty of time to freely gather and develop novel approaches to how to engineer life.

General Physics

Biophysics, Medical Physics,    Organometallic Chemistry, Coordination Chemistry

European Molecular Biology Organization – EMBO

Regulation of translation is key in the control of gene expression, playing a critical role in many biological and pathophysiological settings. In the last decade, methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes, however, the systems-wide analysis of translation remained an unsolved experimental challenge. The advent of ‘ribosome-profiling’ provided the methodological basis for comprehensive transcriptome-wide analyses of translation at sub-codon resolution by the precise and high-throughput determination of ribosomal positions on mRNA. Its application in a variety of organisms yielded novel insights into protein synthesis and its dynamic regulation, significantly advancing our understanding of the post-transcriptional regulation of gene expression.

European Molecular Biology Organization – EMBO

Biology,    Multimedia, Computer Graphics and Visualization, Games

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Ferroptosis is a regulated necrotic cell death modality which is now recognized as an evolutionary vulnerability caused by the incorporation of oxidation-prone polyunsaturated fatty acids (PUFAs) into cellular membranes. This metabolic cell death process provides the framework to understand the basic biological phenomena of how cells restrain, repair and adapt to phospholipid damage through changes in cellular plasticity. A close interplay between cellular metabolism and ferroptosis was established with phospholipid repair linked to numerous metabolic networks including amino acids, glutathione biosynthesis, NAD(P)H and PUFA metabolism, iron handling and the mevalonate pathway. Notably, this complex network has been found to be dysfunctional in different pathological contexts. This EMBO workshop will bring together scientists from different disciplines interested in the molecular mechanisms linked to ferroptosis, such as lipid signalling, redox chemistry, drug discovery, tumour biology, degenrative diseases, medicine and inflammation, and related experts in cell metabolism. This highly interdisciplinary meeting will promote the exchange of ideas and stimulate a critical assessment of the state-of-the-art between students, postdocs and leading researchers from different fields worldwide.

European Molecular Biology Organization – EMBO

The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

Biology,    Career, Leadership and Management

This symposium explores the many ways by which the genome is regulated in the brain in order to support neural function and plasticity. The extraordinary complexity of the brain places unique demands on the genome: How are several hundreds of different neural types specified by the same genetic instructions? Does the genome provide information that guides their connectivity? How is neural activity regulated by and how does it affect genome output? We will explore these fundamental questions from the standpoint of transcriptional regulation and chromatin-based processes, including but not limited to histone marks and variants, chromatin topology and folding, coding and noncoding RNAs, transposable elements, and DNA modifications. The conference aims to bring together neuroscientists and experts in genome regulation. It will cover a broad range of experimental approaches and model systems, from biochemistry to single-cell genomics, from worms to human organoids. Overall, the conference will address the impact of genome regulation on unique features of the brain — its excitable nature, exquisite response to the environment and parallel processing capacity — with the longer-term vision of understanding how defective genome regulation can give rise to brain disease.

Interplay between gene regulation and neuronal activity, Genomic regulation of brain plasticity and behaviour, Chromatin variations in the brain, From one genome to many neurons: neurodevelopment and neural diversity

Neurology,    Genomics and Bioinformatics

European Molecular Biology Laboratory | EMBL

This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms. Invited guest researchers together with microscopy experts from the EMBL will foster an intense information flow with a balance of lectures and practical workshops. The focus of the course will be on the use of fluorescence microscopy to obtain information about localisation and functions of proteins and other bio-molecules at different spatial scales.

Biology,    Microscopy

European Molecular Biology Organization – EMBO

Biology,    Career, Leadership and Management

We are at the dawn of a new era of biology where we will start to understand how organisms function together and react or adapt to changes at different molecular levels. This includes the multitude of stresses that organisms are exposed to, from malnutrition and adverse climate events to many other biological, chemical and physical insults. Progress in biological analyses at both a single scale and across scales, have allowed us to further understand organisms in the context of dynamic environments. These can be environments which are changed by disease, commensal cohabitation or competition, as well as abiotic factors. With the molecular understanding we already have at the cellular and organismal levels, and new tools and quantitative approaches, this symposium will address how genotype and the environment bring about phenotypes at the population level.

Planetary biology, Microbial ecosystems, Human ecosystems, Life in context: theory, Learning from the past: paleobiology

European Molecular Biology Laboratory | EMBL

This course will teach the biological researchers how to analyse biological data sets using open-source software. Most of the analysis will be performed with docker4seq and rCASC packages, which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis. Docker4seq and rCASC packages use docker containers that embed demanding computing tasks (e.g. short reads mapping) into isolated containers. This approach provides multiple advantages: the user does not need to install all the software on its local server, the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used for the analysis. Computers for hands-on exercises will be provided along with demo data sets.

Application Software,    Scientific Computing and Data Science

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The aim is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

Biology,    Career, Leadership and Management

European Molecular Biology Organization – EMBO

Since 2009 the Glyco-Bioinformatics Symposium aims at establishing a network of experts in glycochemistry, biology, bioinformatics and computer sciences. In addition, it provides a platform to discuss the latest outcomes presented by the MIRAGE Commission.

Unparalleled diversity and functionality of the glycome

Genomics and Bioinformatics,    Scientific Computing and Data Science

European Molecular Biology Organization – EMBO

Biology,    Career, Leadership and Management

European Molecular Biology Organization – EMBO

Biology,    Biophysics, Medical Physics

European Molecular Biology Laboratory | EMBL

As fluorescence lifetime-based readouts become more accessible, this course aims to provide a broad understanding of how the lifetime-based information can be leveraged to solve biological questions. This application-centred course will provide insights into how this additional dimension of fluorescence information can help unveil functional and mechanistic information.

Biology,    Microscopy

European Molecular Biology Organization – EMBO

Recent progress in biology has led to an explosion of factual knowledge about the living world over a huge range of scales in space and time. Yet, many questions about how to make sense of this data remain across the entire diversity of the living world from the smallest bacterium to the ecosystems of the Serengeti. This meeting aims to bring together a diverse collection of researchers interested in finding ways to parlay this ever-increasing factual knowledge into a corresponding array of conceptual knowledge. The goal of this symposium is to assemble an interdisciplinary community and to provide a platform to discuss perspectives on the role of theory in biology, and importantly also vice versa, the impact that biology can have on theory.

Biology,    Systems Biology and Computational Biology

European Molecular Biology Organization – EMBO

Biology,    Systems Biology and Computational Biology

European Molecular Biology Laboratory | EMBL

Mechanisms that shape cellular proteomes are critical for life. This conference focuses on the process of protein synthesis, from the molecular and structural understanding of the translational machinery to its regulation, its implications in cell and organismal biology, and its alteration in disease. The regulation of mRNA translation is critical to maintain cell homeostasis and mediates cellular responses to environmental, physiological, and pathological cues. Given the central importance of protein synthesis, it is unsurprising that dysregulation or defects in mRNA translation are widely linked to disease, including cancer, neurological or metabolic disorders, and viral infection. In recent years, technical advances have challenged hitherto established dogmas, uncovered new quality control mechanisms, expanded the breath of translation regulators, enhanced our understanding of the dynamics of translation in living cells, and revealed unexpected interconnections with other cellular processes such as metabolism. Advances on these aspects of mRNA translation will be featured, as well as new insights into translation regulation in physiology and disease.

European Molecular Biology Organization – EMBO

Biology,    Microscopy

The Beilstein Enzymology Symposia series provide not only a platform for the presentation of the latest findings in mechanistic and systemic enzymology but also for discussing standards for measuring and publication of experimental data such as proposed by the STRENDA Commission.

European Molecular Biology Organization – EMBO

European Molecular Biology Laboratory | EMBL

This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies.

Biotechnology,    Genomics and Bioinformatics

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease.

In situ structural biology, Super-resolved imaging, Probes & biosensors, Organismal imaging, Correlative imaging, Image analysis, Discoveries by bioimaging

Biology,    Microscopy

European Molecular Biology Organization – EMBO

Over the past decades it became evident that a RNA transcripts specific amount and localisation are important in order to understand the biological function of its (non-) coding gene. Whereby state-of-the-art in situ hybridisation (ISH) technologies are key to visualise these RNAs in a given tissue or cell. This course aims to highlight three powerful RNA visualisation techniques in histological tissue samples. During this course, the participants will learn to validate the cellular localisation of candidate genes from transcriptome studies through conventional ISH and, the more recent cutting-edge, smFISH (Single Molecule Fluorescent ISH) and HCR-ISH (Hybridization Chain Reaction), based RNA ISH hybridisation methods. Additionally, the course will also cover essential tissue embedding protocols that are adapted for use in visually interrogating RNA transcripts in mammalian tissues.

European Molecular Biology Laboratory | EMBL

This course consists of two parts: virtual and onsite. The virtual course takes place 6 – 10 November 2023 and the onsite part takes place 27 November – 1 December 2023.

The virtual course will cover the basics of SAXS/SANS, instrumentation, data collection, modelling techniques and complementary use with other methods. The students are encouraged to sign-up for a self-paced practical tutorial that covers basic and advanced SAXS data processing steps (including quizzes to keep track of successful participation). In addition, students are encouraged to apply to the ‘add on module’ which includes an on-site visit (5 days) in Hamburg to participate either in track 1: X-ray beamline operation or track 2: sample optimisation for SAXS. Students not travelling to Hamburg can sign up for small discussion groups to discuss their SAXS data in more detail.

Biology,    Biochemistry and Medicinal Chemistry, Toxicology

European Molecular Biology Laboratory | EMBL

Flow Cytometry is one of the most powerful single cell analysis methods used throughout the life sciences and medicine. By utilising Flow Cytometry we can identify and quantify specific cell populations from heterogeneous samples, analyse the cell cycle or proliferation state or simply detect the expression of fluorescent reporters. In line with the suggestions from our course in 2019, we will significantly enhance the number of analysis sessions together with our partners from FlowJo. We will cover the theory of Flow Cytometry and corroborate this information intensively with the practical issues of the most frequent assays as part of our practical course curriculum.

European Molecular Biology Laboratory | EMBL

European Molecular Biology Organization – EMBO

Biology,    Systems Biology and Computational Biology

European Molecular Biology Organization – EMBO

This inaugural EMBO | EMBL Symposium aims to showcase the future of plant biology. Going beyond the limited number of model plants that plant biologists have historically focused on (e.g. Arabidopsis, corn, rice), it is nowadays possible to use comparative approaches to uncover the mechanistic basis and the evolutionary drive for the enormous phenotypic variation among the 400,000 species of plants on Earth.