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European Molecular Biology Organization – EMBO

The Hedgehog morphogen pathway is a key signalling pathway in development and stem cell regulation. Hedgehog deregulation leads to developmental and neurological diseases and is a crucial driver of several cancers. The goal of this conference is to bring together experts working on the mechanism of action of Hedgehog signalling in Developmental Biology, Disease, and Signal Transduction. The meeting will focus on the recent structural, biochemical, and cell-biological studies that shed new light on the mechanisms by which the Hedgehog signal is received on target cells and the unexpected role of cholesterol as a second messenger. Moreover, the recent advances in understanding the molecular mechanisms underlying the Hedgehog morphogen biosynthesis, its release from cells into extracellular space, and the mechanisms involved in ligand reception will be discussed. We will also cover the most recent insights into Hedgehog-dependent control of cell proliferation and differentiation in processes that range from insect morphogenesis to vertebrate limb formation, neural tube development, and bone differentiation. 

European Molecular Biology Organization – EMBO

Cell polarization is an essential first step for many biological processes ranging from cell motility to tissue and organism morphogenesis. At the same time, cell polarization requires a precise control of their internal organization, which is the result of a complex dynamic interplay between the cytoskeleton, molecular motors, signaling molecules, and membranes. Recent technological advances have helped obtaining valuable new information on the different temporal and spatial scales that govern cell polarization. We have obtained structures of membrane-localized protein complexes, demonstrated the emergent self-organizing properties of proteins and cellular systems and shed light on how to modulate the shape of membranes and tissues to build entire tissues or organisms. To develop a mechanistic understanding of these processes, we need to integrate our existing knowledge on cell polarization, from the tissue level down to individual molecules, obtained from minimal reconstituted systems to whole animals, from experimental and theoretical approaches. This EMBO Workshop will bring together a highly diverse group of scientists (cell & structural biologists, (bio)chemists, experimental & theoretical physicists) to present the state-of-the-art of their fields, to exchange ideas, and to identify synergies between them to establish new collaborations and open new research fields.

European Molecular Biology Organization – EMBO

Biology,    Systems Biology and Computational Biology

European Molecular Biology Organization – EMBO

The antibody response and the complement system are major effector arms of the immune system. Next to their beneficial roles in host defense, antibodies and complement are also involved in a plethora of pathological conditions—including autoimmunity, allergy and cancer—and regulate, mainly through their receptors (FcR and CR respectively) cell activation, migration, survival but also metabolism. As the portfolio of antibody—and complement-effector function grow, high-end technological solutions are developed, and novel therapeutic applications are proposed. This EMBO Workshop on Antibody & Complement will be a forum for leaders in the field and new investigators coming from academia, industry and research institutes to discuss where the field is going and what challenges lie ahead. We will focus attention on key advances in both fields with the aim at fostering discussions between antibody experts and complement experts.

This GRC will be held in conjunction with the "Wnt Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information. Conference Program The session topics for this conference are being developed by the conference chairs. Please check back regularly for updates to this information. Contributors Gordon Research Conferences National Institutes of Health - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ImmunoPrecise Antibodies STEMCELL Technologies Inc. PeproTech Inc. Pfizer, Inc. Bio-Techne JW Pharmaceutical Corporation Leap Therapeutics Conference Links Conference History Wnt Signaling (GRS) Contribute Financially to This Conference Conference Fees Similar Conferences Poster Information Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

This EMBO Workshop will bring together an interdisciplinary and diverse group of scientists discussing recent developments and cutting-edge advances in LD research. The meeting is going to provide a unique platform for exchange between basic and clinical researchers across all career levels with ample opportunity for networking and career development.

European Molecular Biology Organization – EMBO

Genome evolution represents the basis of species adaptation to changing environments and habitats. Recent breakthroughs in sequencing technologies resulted in the acquisition of complete genome information for an increasing number of animal species, propelling the field of evolutionary genomics into a new era of discovery. Yet, our limited capacity to interpret genome variation hinders our understanding on how phenotypical changes drive adaptation. This urges the development of novel strategies to reconcile genomic sequence and function, for which a proper integration of cell-specific gene programs, non-coding regulation and 3D chromatin organization becomes essential. Further, establishing causal relationships between genome mutations and phenotypes still remains a major challenge in the field. Within this context, novel synthetic biology approaches are emerging as a means to understand developmental processes in the context of evolution. The aim of this EMBO workshop is to bring together international scientists with distinct, but complementary expertises on interpreting genome variation, on mechanisms of gene regulation and on in vivo synthetic biology approaches. This allows a comprehensive overview that goes from fundamental principles encoded in genomes to their ultimate biological significance on the formation of living, evolving organisms.

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO