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European Molecular Biology Organization – EMBO

Advanced reproductive technologies, such as intracytoplasmic sperm injection, have revolutionized reproductive medicine by enabling effective fertilization without the need to understand the cause of infertility. However, declining male fertility persists in many countries, and growing evidence suggested that the reproductive health of fathers affects their children’s health, calling for continuing investigation of the underlying mechanisms. The main themes of this EMBO Workshop are the male reproductive system, testis development, and sperm formation in mammals, including humans and animal models. Reflecting the multifaceted nature of male reproduction and discoveries made by increasingly advanced experimental techniques, the three broad topics further branch into sub-topics including genetics, epigenetics, immunity, lifestyle influences, toxicity, immunology, and endocrinology. Clinically relevant topics—semen function, sperm physiology, reproductive technologies, and fertility preservation—are also incorporated. This EMBO Workshop aims to bridge the knowledge gap in male reproduction, facilitate networking among research groups with different expertise, and promote the translation of fundamental research in male reproduction into diagnoses and therapies.

Unraveling the Mechanisms of Membrane Transport: Structure, Dynamics and Allosteric Regulation

European Molecular Biology Organization – EMBO

European Molecular Biology Organization – EMBO

Following the elucidation of the structure of DNA, it was clear that the iconic double helical structure of DNA would impact and impede the fundamental genomic transactions required for cellular life. Even after 70 years of research, novel roles for DNA topology and topoisomerase action in transcriptional control, chromosome structure, anti-viral responses and genome stability are still being uncovered. We are also still deciphering how many chemotherapeutics target topoisomerases and DNA topology impacted processes. The EMBO workshops on DNA topology and topoisomerases bring together scientists who have only recently discovered the importance of DNA topology in their specialties with long standing researchers in the field. This generates a vibrant interdisciplinary meeting, which highlights and disseminates work involving diverse and rapidly evolving approaches. This workshop highlights studies using techniques as varied as single molecule physics and structural biology, pan-genomic analysis of chromosome structure and chromatin composition and live cell single particle tracking to uncover new findings on the nature of DNA topological transactions and how they impact cellular processes.