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1
From Physics to Function
09 Oct 2022 - 12 Oct 2022 • Buxted Park, East Sussex, United Kingdom
Organizer:
The Company of Biologists Ltd
Abstract:
With the increased appreciation that physical forces are key regulators of all biological processes, new emerging scientific communities are forming around topics such as physical forces in cancer and mechanobiology in different biological processes ranging from development to homeostasis. Currently, there exists somewhat of a void between the biologists and the physicists working on these topics. The interests are shared but the communication between the two crowds is limited by the lack of a common language. On one hand, there are vast advances being made in generating tuneable materials, versatile biomimetic polymers and artificial 3D scaffolds, and these are linked to advanced modelling and understanding of the physical parameters of these systems. However, the biological questions addressed may have limited physiological relevance and lack careful consideration of the burning questions in biology. On the other side, the cell biologists/developmental biologists/cancer biologists lack contact with the physicists, modellers and material scientists, and are unable to connect their biology to the relevant physical principles and available methodology. They lack understanding of the theory behind tissue mechanics and the engineering skills to investigate them. They would benefit massively from closer collaboration with the “other crowd”. Therefore, the main goal of this Workshop is to foster integration between physics and biology across scales, approaches, and participant backgrounds. The Workshop will be entail “biology-physics duets” – talks given jointly by two currently collaborating speakers, with different backgrounds. These will be accompanied by “solo” talks and relevant round table discussions on how physics and biology can be better integrated.
Topics:
1) Mechanotransduction from cell adhesions to the nucleus 2) Cytoskeleton mechanics and migration 3) Modelling of biological processes across scales 4) Top-down versus bottom-up approaches to living systems 5) How to promote cross-disciplinary research on biologically relevant questions
Event listing ID:
1473244
Related subject(s):
2
Developmental Metabolism and the Origins of Health and Disease
24 Oct 2022 - 27 Oct 2022 • Buxted Park, East Sussex, United Kingdom
Organizer:
The Company of Biologists Ltd
Event listing ID:
1473210
Related subject(s):
3
Genotype to Phenotype: Bridging Comparative Genomics and Cell Biology
13 Nov 2022 - 16 Nov 2022 • Buxted Park, East Sussex, United Kingdom
Organizer:
The Company of Biologists Ltd
Abstract:
In this Workshop, we aim to bring together computational, cell, and evolutionary biologists to help address this major challenge of integrative cell biology. We strongly believe that actively seeking out collaboration across fields will be crucial to push cell biology beyond the boundaries of individual species into a truly comparative discipline anchored to predictive models. In turn, computational biologists will have an opportunity to guide and influence the next phase of big data generation in cell biology. Together, in deciphering the rules that underpin the relationship between the genome and the cell that encases it, we will better understand both evolution and cellular function.
Event listing ID:
1473264
4
Toxic Metabolites in the Biology of Ageing and Cancer
04 Dec 2022 - 07 Dec 2022 • Buxted Park, East Sussex, United Kingdom
Organizer:
The Company of Biologists Ltd
Abstract:
This Workshop will focus on the biology of toxic metabolites in the ageing process, stem cells and cancer. Specific emphasis will be placed on how metabolites that carry carbonyls (such as aldehydes and ketones) damage stem and cancer cells. A particular area will focus on endogenous aldehydes (such as acteladehyde, formaldehyde and methyl-gyoxal), the enzymes that remove them [aldehyde dehydrogenases (Aldh) and functionally related glutathione-based enzymes such as Adh5 and Glo-1/2]. Further, we will consider how human genetic variation can contribute to metabolite sensitivity, and how mutations in cancer genomes in toxic metabolism pathways can be exploited for therapy.
Event listing ID:
1476599
Related subject(s):
5
Workshop — Collective Cell Migration: From In Vitro to In Vivo
19 Feb 2023 - 22 Feb 2023 • Wiston House, West Sussex, United Kingdom
Organizer:
The Company of Biologists Ltd
Abstract:
Collective cell migration has paramount importance for embryogenesis, tissue repair and cancer progression. This phenomenon spans from the microscopic, molecular scale of cell signalling and cell-cell interactions, to the macroscopic, tissue-level scale of multicellular dynamics, and is amenable to both experimental and theoretical investigations. Collective cell migration is distinctly different from single cell migration in terms of its biological complexity and theoretical treatment. Our interdisciplinary program focuses on four key topics of collective cell migration, ranging from the molecular to the organismal level.
Topics:
Cellular mechanisms of collective movement and metastasis, Mechanobiology of morphogenesis, Biophysical and mathematical modelling of collective movement and morphogenesis, In vivo imaging of migration and metastasis
Event listing ID:
1495841
6
Workshop — Novel Technologies for Programming Human Cell Fate
26 Mar 2023 - 29 Mar 2023 • Eastwell Manor, Kent, United Kingdom
Organizer:
The Company of Biologists Ltd
Abstract:
This Workshop unites experts in human cell fate engineering and experts in the manipulation and characterisation of single cells. The goal is to fully understand the molecular steps underlying the transformation of one cellular identity into another. The cross-disciplinary selection of speakers spans the fields of cell fate engineering and emerging technologies to analyse and manipulate cells at single-cell resolution.
Topics:
Direct lineage reprogramming approaches, Assessment of reprogramming inefficiency and infidelity, Engineering cells with defined identity through new methods, De novo predictions of factors and conditions for target cell type generation
Event listing ID:
1495840
Related subject(s):


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Last updated: 8 July 2022